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Merck
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SAB4502131

Anti-RNF138 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

E3 ubiquitin-protein ligase RNF138, NLK-associated RING finger protein, Nemo-like kinase-associated RING finger protein, RING finger protein 138

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 28 kDa

species reactivity

human, mouse, rat

concentration

~1 mg/mL

technique(s)

ELISA: 1:20000
western blot: 1:500-1:1000

NCBI accession no.

Q8WVD3

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RN138(51444)

Related Categories

General description

Anti-RNF138 antibody detects endogenous levels of total RNF138 protein.
The RNF138 (RING (really interesting new gene) finger protein 138) gene is mapped to human chromosome 18q12.1 and is predominantly expressed in testis. It encodes an E3 ubiquitin ligase, which is a CaV2.1 (voltage gated calcium channel) binding protein. It is a 245 amino acid protein containing a RING (really interesting new gene) domain at the N-terminal, zinc fingers, and an ubiquitin interacting motif at the C-terminal.

Immunogen

The antiserum was produced against synthesized peptide derived from human RNF138.

Immunogen Range: 31-80

Biochem/physiol Actions

Upregulation of RNF138 (RING (really interesting new gene) finger protein 138) induces polyubiquitination and increases the synthesis/degradation of CaV2.1 (voltage gated calcium channel). In response to DNA damage, RNF138 is localized to the DNA damage site mediated by zinc fingers. Deletion of RNF138 increases the sensitivity to DNA damaging agents and chromosomal instability. RNF138 is upregulated in gliomas.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
3115572

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RNF138 interacts with RAD51D and is required for DNA interstrand crosslink repair and maintaining chromosome integrity.
Yard BD
DNA Repair, 42, 82-93 (2016)
Ubiquitin Ligase RNF138 Promotes Episodic Ataxia Type 2-Associated Aberrant Degradation of Human Cav2.1 (P/Q-Type) Calcium Channels.
Fu SJ
The Journal of Neuroscience, 37(9), 2485-2503 (2017)
A novel gene RNF138 expressed in human gliomas and its function in the glioma cell line U251.
Zhou YX
Analytical Cellular Pathology (Amsterdam), 35(3), 167-178 (2012)
Genotype-phenotype analysis of 18q12.1-q12.2 copy number variation in autism.
Wang P
European Journal of Medical Genetics, 56(8), 420-425 (2013)
ABCG1 and ABCG4 Suppress ?-Secretase Activity and Amyloid ? Production.
Sano O
PLoS ONE, 11(5), 1-19 (2016)

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