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Merck
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SAB4502917

Anti-TP53INP2 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

PIG-U, p53-inducible protein U

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 23 kDa

species reactivity

human, rat, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100

NCBI accession no.

Q8CFU8

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TP53INP2(58476)
mouse ... T53I2(68728)

Related Categories

General description

Anti-TP53INP2 Antibody detects endogenous levels of total TP53INP2 protein.
TP53INP2/DOR (tumor protein p53 inducible nuclear protein 2) is located in the nucleolus. It is ubiquitously present in the tissues, with a high metabolism level. TP53INP2 is located on human chromosome 20q11.22.

Immunogen

The antiserum was produced against synthesized peptide derived from human TP53INP2.

Immunogen Range: 1-50

Biochem/physiol Actions

TP53INP2/DOR (tumor protein p53 inducible nuclear protein 2) acts as a promoter of autophagy and is involved in cell catabolism. It is essential for rDNA transcription. TP53INP2 is required for protein synthesis and cell proliferation. It also acts as a coactivator of the thyroid hormone receptor and regulates the activities of thyroid hormone.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
3111320

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TP53INP2/DOR, a mediator of cell autophagy, promotes rDNA transcription via facilitating the assembly of the POLR1/RNA polymerase I preinitiation complex at rDNA promoters.
Xu Y, et al.
Autophagy, 12(7), 1118-1128 (2016)
Takaya Ishihara et al.
Cancer science, 99(10), 1940-1949 (2008-11-20)
Anaplastic thyroid carcinoma (ATC) is one of the most virulent of all human malignancies, with a mean survival time among patients of less than 1 year after diagnosis. To date, however, cytogenetic information on this disease has been very limited.
Hamish Crerar et al.
Neuron, 102(3), 553-563 (2019-03-12)
Neurons are extraordinarily large and highly polarized cells that require rapid and efficient communication between cell bodies and axons over long distances. In peripheral neurons, transcripts are transported along axons to growth cones, where they are rapidly translated in response

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