Skip to Content
Merck
CN

SAB4504289

Anti-phospho-p47 phox (pSer359) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-CGD1, Anti-NCF1A, Anti-NOXO2, Anti-SH3PXD1A, Anti-p47phox

Sign In to View Organizational & Contract Pricing

Select a Size

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 44 kDa

species reactivity

rat, mouse, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

P14598

UniProt accession no.

P14598

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer359)

Gene Information

human ... NCF1(653361)

Related Categories

General description

Phospho-p47/ NCF1 (neutrophil cytosolic factor-1) codes for the p47phox subunit of the phagocyte NADPH oxidase (NOX2). It is a cytosolic factor. This gene is located with two pseudogenes (NCF1B and NCF1C). NCF1 is mapped to human chromosome 7q11.23.

Immunogen

The antiserum was produced against synthesized peptide derived from human p47 phox around the phosphorylation site of Ser359.

Immunogen Range: 331-380

Biochem/physiol Actions

NCF1 (neutrophil cytosolic factor-1) is an important constituent of the phagocyte NADPH-oxidase system. The enzyme helps in the synthesis of microbicidal superoxide in phagocytes like neutrophil and plays a key role in host defense against microbial pathogens. A 2-bp GT deletion in exon 2 of the NCF1 gene results in chronic granulomatous disease (CGD).

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Product Selector Tool.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
111172

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

A missense variant in NCF1 is associated with susceptibility to multiple autoimmune diseases.
Zhao J, et al.
Nature Genetics, 49(3), 433-437 (2017)
Genomic structure of the human p47-phox (NCF1) gene.
Chanock SJ, et al.
Blood Cells, Molecules and Diseases, 26(1), 37-46 (2000)
A copy number variation in human NCF1 and its pseudogenes.
Brunson T, et al.
BMC Genetics, 11(1), 13-13 (2010)
Glaucy Rodrigues de Araújo et al.
Experimental biology and medicine (Maywood, N.J.), 242(3), 333-343 (2017-01-21)
Baccharis trimera, popularly known as "carqueja", is a native South-American plant possessing a high concentration of polyphenolic compounds and therefore high antioxidant potential. Despite the antioxidant potential described for B. trimera, there are no reports concerning the signaling pathways involved

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service