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SAB4504289

Anti-phospho-p47 phox (pSer359) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-CGD1, Anti-NCF1A, Anti-NOXO2, Anti-SH3PXD1A, Anti-p47phox

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IF, IHC, WB
Citations:
4
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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 44 kDa

species reactivity

rat, mouse, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:5000, immunofluorescence: 1:100-1:500, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000

NCBI accession no.

P14598

UniProt accession no.

P14598

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer359)

Gene Information

human ... NCF1(653361)

General description

Phospho-p47/ NCF1 (neutrophil cytosolic factor-1) codes for the p47phox subunit of the phagocyte NADPH oxidase (NOX2). It is a cytosolic factor. This gene is located with two pseudogenes (NCF1B and NCF1C). NCF1 is mapped to human chromosome 7q11.23.

Immunogen

The antiserum was produced against synthesized peptide derived from human p47 phox around the phosphorylation site of Ser359.

Immunogen Range: 331-380

Biochem/physiol Actions

NCF1 (neutrophil cytosolic factor-1) is an important constituent of the phagocyte NADPH-oxidase system. The enzyme helps in the synthesis of microbicidal superoxide in phagocytes like neutrophil and plays a key role in host defense against microbial pathogens. A 2-bp GT deletion in exon 2 of the NCF1 gene results in chronic granulomatous disease (CGD).

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品
低风险生物材料

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Certificates of Analysis (COA)

Lot/Batch Number
111172

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A copy number variation in human NCF1 and its pseudogenes.
Brunson T, et al.
BMC Genetics, 11(1), 13-13 (2010)
A missense variant in NCF1 is associated with susceptibility to multiple autoimmune diseases.
Zhao J, et al.
Nature Genetics, 49(3), 433-437 (2017)
Genomic structure of the human p47-phox (NCF1) gene.
Chanock SJ, et al.
Blood Cells, Molecules and Diseases, 26(1), 37-46 (2000)
View All Related Papers

Global Trade Item Number

SKUGTIN
SAB4504289-100UG04061832524856