SAB4700514
Monoclonal Anti-TCR beta antibody produced in mouse
clone MEM-262, purified immunoglobulin, buffered aqueous solution
Synonym(s):
Anti-TCR β (Vβ5.3-related)
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
MEM-262, monoclonal
Application:
FACS
Citations:
3
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
MEM-262, monoclonal
form
buffered aqueous solution
species reactivity
human
concentration
1 mg/mL
technique(s)
flow cytometry: suitable
isotype
IgG2a
NCBI accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TRB@(6957)
Related Categories
General description
The antibody MEM-262 recognizes β chains of the TCR expressed by HPB-ALL cell line [carrying V(beta5.3)] and a small subset of peripheral blood T cells.
TCR β/TCRB (T cell receptor β chain) is located on human chromosome 7q34. This gene has at least 65 rearrangeable Vβ gene segments (27 Vβ families), two Dβ segments (Dβ1 and Dβ2), two clusters of Jβ gene segments (Jβ1.1–Jβ 1.6 and Jβ2.1–Jβ2.7) and two Cβ gene segments.
TCR β/TCRB (T cell receptor β chain) is located on human chromosome 7q34. This gene has at least 65 rearrangeable Vβ gene segments (27 Vβ families), two Dβ segments (Dβ1 and Dβ2), two clusters of Jβ gene segments (Jβ1.1–Jβ 1.6 and Jβ2.1–Jβ2.7) and two Cβ gene segments.
Immunogen
Human thymoma cell line HPB-ALL
Application
The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 2-8 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
Biochem/physiol Actions
The complementary determining region 3 (CDR3) of the TCR β/TCRB (T cell receptor β) is essential for the identification of the major histocompatibility complex (MHC)−peptide complex.
Features and Benefits
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Physical form
Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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T-lineage acute lymphoblastic leukemia (T-ALL)
Raimondi S C
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2007)
TCRB gene rearrangements in childhood and adult precursor-B-ALL: frequency, applicability as MRD-PCR target, and stability between diagnosis and relapse
Van der Velden, et al.
Leukemia, 18(12), 1971-1971 (2004)
The T-cell receptor repertoire influences the tumor microenvironment and is associated with survival in aggressive B-cell lymphoma
Keane C, et al.
Clinical Cancer Research, 23(7), 1820-1828 (2017)
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