SAB5702923
[KO Validated]Anti-Bax Antibody, clone 0Q4B3, Rabbit Monoclonal
Synonym(s):
BCL2L4
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About This Item
NACRES:
NA.46
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
0Q4B3, monoclonal
Application:
IF, IHC, IP, WB
Citations:
-
biological source
rabbit
conjugate
unconjugated
material
colorless
clone
0Q4B3, monoclonal
form
liquid
mol wt
21 kDa
concentration
1.00 mg/mL
technique(s)
immunofluorescence: 1:50 - 1:200, immunohistochemistry: 1:50 - 1:200, immunoprecipitation (IP): 1:50 - 1:100, western blot: 1:500 - 1:2000
color
colorless
isotype
IgG
immunogen sequence
GGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLSECLKRIGDEL
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... BAX(581)
species reactivity
human
General description
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 10-70 of human Bax (NP_620116.1).
PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Application
WB, IHC, IF/ICC, IP
signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 2 - Skin Sens. 1
Storage Class
10 - Combustible liquids
Regulatory Information
低风险生物材料
常规特殊物品
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