SML0174
GPR35 Agonist, Compound 10
≥98% (HPLC)
Synonym(s):
2-[4-[(2,4-Dioxo-5-thiazolidinylidene)methyl]phenoxy]-acetic acid
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About This Item
Empirical Formula (Hill Notation):
C12H9NO5S
CAS Number:
Molecular Weight:
279.27
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Product Name
GPR35 Agonist, Compound 10, ≥98% (HPLC)
InChI
1S/C12H9NO5S/c14-10(15)6-18-8-3-1-7(2-4-8)5-9-11(16)13-12(17)19-9/h1-5H,6H2,(H,14,15)(H,13,16,17)/b9-5-
SMILES string
OC(=O)COc1ccc(cc1)\C=C2/SC(=O)NC2=O
InChI key
WXMCOLGPDOYHNK-UITAMQMPSA-N
assay
≥98% (HPLC)
form
powder
color
white to tan
solubility
DMSO: ≥5 mg/mL at ~60 °C
storage temp.
2-8°C
Quality Level
Related Categories
Application
GPR35 Agonist, Compound 10, may be used in GPR35-mediated cell signaling studies.
Biochem/physiol Actions
GPR35 Agonist
GPR35 agonist Compound 10 is a GPR35 agonist the binds with higher affinity than other known agonists, such as kynurenic acid and zaprinast. Compound 10 was more potent than zaniprast (pEC50 = 5.3 vs 4.18) for recombinantly expressed human GPR35, and unlike zaprinast, is equipotent for human and rat GPR35
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Ida Marie Modvig et al.
American journal of physiology. Endocrinology and metabolism, 320(5), E874-E885 (2021-03-02)
The aim of this study was to explore individual amino acid-stimulated GLP-1 responses and the underlying stimulatory mechanisms, as well as to identify the amino acid-sensing receptors involved in amino acid-stimulated GLP-1 release. Experiments were primarily based on isolated perfused
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