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SML2235

CL075

≥98% (HPLC)

Synonym(s):

2-Propylthiazolo[4,5-c]quinolin-4-amine, 3M002

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About This Item

Empirical Formula (Hill Notation):
C13H13N3S
CAS Number:
256922-53-9
Molecular Weight:
243.33
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD09998898
Assay:
≥98% (HPLC)
Form:
powder
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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

[s]1c2c(nc1CCC)c(nc3c2cccc3)N

InChI

1S/C13H13N3S/c1-2-5-10-16-11-12(17-10)8-6-3-4-7-9(8)15-13(11)14/h3-4,6-7H,2,5H2,1H3,(H2,14,15)

InChI key

NFYMGJSUKCDVJR-UHFFFAOYSA-N

Application

CL075 has been used to activate the monocyte-derived dendritic cells (DCs) to demonstrate the ability of DCs to induce cell death.

Biochem/physiol Actions

CL075 is a selective agonist of Toll-like receptor-8 (TLR-8) with immunostimulant activity. It showed an EC50 value of 400nM for IRF-NFΚB stimulation in TLR8 compared to 4 μM for TLR7.
CL075 is a thiazoloquinolone derivative. It might influence tumor development.
Toll-like receptor-8 (TLR-8) agonist

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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