SML3690
Serodolin
≥98% (HPLC)
Synonym(s):
1-(5-(4-(4-Fluorophenyl)piperazin-1-yl)pentyl)-1H-benzo[d]imidazol-2(3H)-one, 1-[5-[4-(4-Fluorophenyl)-1-piperazinyl]pentyl]-1,3-dihydro-2H-benzimidazol-2-one
Sign In to View Organizational & Contract Pricing.
Select a Size
About This Item
Empirical Formula (Hill Notation):
C22H27FN4O
CAS Number:
Molecular Weight:
382.47
UNSPSC Code:
12352200
NACRES:
NA.77
SMILES string
O=C1NC2=C(N1CCCCCN3CCN(CC3)C4=CC=C(C=C4)F)C=CC=C2
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Related Categories
Biochem/physiol Actions
β-arrestin-biased 5-HT7-selective agonist with antagonist/inverse agonist activity against Gs signaling and in vivo antinociceptive efficacy in mouse pain models.
Serodolin is a β-arrestin-biased, 5-HT7-selective 5-hydroxytryptamine receptor agonist (5HT7/2A/1A/6 Ki = 6.2/19/454/1224 nM) that induces ERK activation through a β-arrestin-dependent signaling mechanism that requires c-SRC activation (309% of basal pErk in 5HT7-transfected HEK293 post 2-15 min 10 μM treatment) while acting as an antagonist/inverse agonist against Gs signaling (IC50 = 14 & 5 nM, respectively, against basal and 10 nM 5-CT-induced cAMP production in 5HT7-transfected HEK293). Serodolin exhibits antinociceptive efficacy in response to inflammatory, thermal, and mechanical stimulation in mice in vivo (0.1-10 mg/kg s.c.).
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Rational Design, Pharmacomodulation, and Synthesis of Dual 5-Hydroxytryptamine 7 (5-HT7)/5-Hydroxytryptamine 2A (5-HT2A) Receptor Antagonists and Evaluation by [(18)F]-PET Imaging in a Primate Brain
Journal of medicinal chemistry, 58(20), 8066-8096 (2015)
Chayma El Khamlichi et al.
Proceedings of the National Academy of Sciences of the United States of America, 119(21), e2118847119-e2118847119 (2022-05-21)
G protein–coupled receptors (GPCRs) are involved in regulation of manifold physiological processes through coupling to heterotrimeric G proteins upon ligand stimulation. Classical therapeutically active drugs simultaneously initiate several downstream signaling pathways, whereas biased ligands, which stabilize subsets of receptor conformations
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service