SML3838
TP003
≥98% (HPLC)
Synonym(s):
2′,4-Difluoro-5′-[8-fluoro-7-(1-hydroxy-1-methylethyl)imidazo[1,2-a]pyridin-3-yl]-[1,1′-biphenyl]-2-carbonitrile, 4,2’-Difluoro-5’-[8-fluoro-7-(1-hydroxy-1-methylethyl)imidazo[1,2-a]pyridine-3-yl]biphenyl-2-carbonitrile, TP-003
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About This Item
Empirical Formula (Hill Notation):
C23H16F3N3O
CAS Number:
Molecular Weight:
407.39
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Quality Level
Related Categories
Biochem/physiol Actions
Potent and subtype selective agonist at α3GABAA receptors
TP003 is a potent and subtype selective agonist at α3 GABAA receptors that exhibits an anxiolytic-like effect in both rodent and non-human primate behavioral models of anxiety. Also it appears that TP003 have anxiolytic properties but lacks ataxic, hyperphagic, and pronounced sedative effects characteristic of classical benzodiazepines in monkeys. TP003 is consider as α3-over-α1 selective positive allosteric modulator (PAM) at GABBAAR.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Contribution of GABA(A) receptors containing ?3 subunits to the therapeutic-related and side effects of benzodiazepine-type drugs in monkeys
Psychopharmacology, 215(2), 311-319 (2011)
Evidence for a significant role of alpha 3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines.
The Journal of Neuroscience, 25(46), 10682-10688 (2005)
Probing the molecular basis for affinity/potency- and efficacy-based subtype-selectivity exhibited by benzodiazepine-site modulators at GABAA receptors
Biochemical Pharmacology, 158, 339-358 (2018)
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