SML3981
CITFA
≥98% (HPLC)
Synonym(s):
2-Cyclohexyl-4-isopropyl-N-((5-(tetrahydro-2H-pyran-2-yl)furan-2-yl)methyl)aniline, N-[2-Cyclohexyl-4-(1-methylethyl)phenyl]-5-(tetrahydro-2H-pyran-2-yl)-2-furanmethanamine
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About This Item
Empirical Formula (Hill Notation):
C25H35NO2
CAS Number:
Molecular Weight:
381.55
UNSPSC Code:
51111800
NACRES:
NA.21
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
2-8°C
SMILES string
CC(C)C(C=C1C2CCCCC2)=CC=C1NCC3=CC=C(C4OCCCC4)O3
InChI
1S/C25H35NO2/c1-18(2)20-11-13-23(22(16-20)19-8-4-3-5-9-19)26-17-21-12-14-25(28-21)24-10-6-7-15-27-24/h11-14,16,18-19,24,26H,3-10,15,17H2,1-2H3
InChI key
GYTVCHRGONLGMD-UHFFFAOYSA-N
Biochem/physiol Actions
Potent and selective G protein-coupled estrogen receptor (GPER) agonist with significantly higher potency than G-1 and greater selectivity than 17β-estradiol (E2).
CITFA is a potent and selective G protein-coupled estrogen receptor (GPER) agonist that specifically inudces calcium mobilizaton in GPER-transfected, but not non-transfected, COS cells. CITFA is more potent than G-1 (Ca2+ EC50 = 38.7 nM vs. 1.71 μM in HL-60 cells) and, unlike 17β-estradiol (E2), exhibits no affinity toward ERα/β (Ki >10 μM). CITFA (100 nM for 72h) significantly increases axonal and dendritic growth in rat embryonic (E18) hippocampal neurons.
CITFA is a potent and selective G protein-coupled estrogen receptor (GPER) agonist that specifically inudces calcium mobilizaton in GPER-transfected, but not non-transfected, COS cells. CITFA is more potent than G-1 (Ca2+ EC50 = 38.7 nM vs. 1.71 μM in HL-60 cells) and, unlike 17β-estradiol (E2), exhibits no affinity toward ERα/β (Ki >10 μM). CITFA (100 nM for 72h) significantly increases axonal and dendritic growth in rat embryonic (E18) hippocampal neurons.
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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