SML4029
NVS-STG2
≥98% (HPLC)
Synonym(s):
Methyl 4-((4-(2-(tert-butyl)-5,5-dimethyl-1,3-dioxan-2-yl)benzyl)amino)-3-methoxybenzoate
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About This Item
Empirical Formula (Hill Notation):
C25H33NO5
CAS Number:
Molecular Weight:
427.53
NACRES:
NA.21
InChI key
CZSPKEVHLRWAFC-UHFFFAOYSA-N
SMILES string
OC(C1=CC=C(NCC2=CC=C(C3(C(C)(C)C)OCC(C)(C)CO3)C=C2)C(OC)=C1)=O
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Related Categories
Biochem/physiol Actions
Potent STING allosteric agonist that induces a STING-mediated immune responses in cells.
NVS-STG2 is a potent STING (stimulator of interferon genes) allosteric agonist (AC=5.2 µM) that induces a STING-mediated immune responses in cells. It elicits potent antitumor activity in animal models. NVS-STG2 acts as molecular glue that binds the transmembrane domains of the neighboring STING dimers.
NVS-STG2 is a potent STING (stimulator of interferon genes) allosteric agonist (AC=5.2 µM) that induces a STING-mediated immune responses in cells. It elicits potent antitumor activity in animal models. NVS-STG2 acts as molecular glue that binds the transmembrane domains of the neighboring STING dimers.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Jie Li et al.
Nature chemical biology, 20(3), 365-372 (2023-10-13)
Stimulator of interferon genes (STING) is a dimeric transmembrane adapter protein that plays a key role in the human innate immune response to infection and has been therapeutically exploited for its antitumor activity. The activation of STING requires its high-order
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