Quality Segment
description
Piericidin A 1% Solution in Ethanol, 1%in Ethanol
assay
≥95% (HPLC)
form
solution
concentration
10 mg/mL
color
colorless to yellow
storage temp.
-10 to -25°C
General description
Piericidin A, an antibiotic isolated from Streptomyces mobaraensis, features a 4-pyridinol core linked with a methylated polyketide side chain, closely resembling coenzyme Q (ubiquinone) in structure.
Application
Piericidin A solution may be used as a control agent for soft rot disease in potato tubers and to evaluate its effects on the expression of virulence genes in Erwinia carotovora. It may also be used as an inhibitor of mitochondrial complex I to study its effects on gluconeogenesis and glucose-lowering mechanisms in the context of metformin and other guanides/biguanides in both in vitro and in vivo experiments.
Biochem/physiol Actions
Piericidin A is a potent irreversible inhibitor of mitochondrial complex I (NADH:ubiquinone oxidoreductase). Piericidin A potently binds to ubiquinone binding sites in both mitochondrial and bacterial forms of the enzyme. Piericidin A exerts its inhibitory effects by binding to the ubiquinone binding site of complex I, effectively blocking the translocation of protons across the mitochondrial membrane.
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Flam. Liq. 2
存储类别
3 - Flammable liquids
wgk
WGK 3
flash_point_f
62.6 °F
flash_point_c
17 °C