T6448
Anti-TREK-1 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-Kcnk2, Anti-Potassium Channel K2P2.1, Anti-TWIK-related K+ channel 1
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
rat
technique(s)
western blot (chemiluminescent): 1:200 using rat brain membranes
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... KCNK2(3776)
rat ... Kcnk2(170899)
General description
Potassium two pore domain channel subfamily K member 2 (KCNK2), also known as TWIK-related K+ channel-1 (TREK1), is expressed in the spinal cord, bladder and dorsal root ganglion. It is part of the TREK family.
Immunogen
synthetic peptide (DPKSA AQNSK PRLSF STKC) corresponding to the intracellular, amino terminus of human TREK-1 (amino acid residues 8-28).
Application
Anti-TREK-1 antibody produced in rabbit has been used in western blotting.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Biochem/physiol Actions
Potassium two pore domain channel subfamily K member 2 (KCNK2) possesses a potassium channel activity. It has a role in stabilizing the resting membrane potential of cells. The protein is also involved in the development of rat heart. TREK-1 could act as a drug target to treat acute heart ischemia.
The antibody reacts with rat TREK-1 (confirmed). It is expected that the antibody will also react with human and mouse TREK-1 due to sequence homology (17/18).
Physical form
Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
常规特殊物品
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Effects of fluoxetine on protein expression of potassium ion channels in the brain of chronic mild stress rats
Chunlin C, et al.
Acta Pharmaceutica Sinica. B, 5(1), 55-61 (2015)
Naaz Andharia et al.
Channels (Austin, Tex.), 11(3), 224-235 (2017-01-14)
The TREK-1 channel, the TWIK-1-related potassium (K
Analysis of gene expression profiles in the programmed cell death rat retinal ganglion cells (RGC-5).
Abdelnaby K, et al.
Cancer Therapy, 6(2) (2008)
Increased Expression of TREK-1 K+ Channel in the Dorsal Root Ganglion of Rats with Detrusor Overactivity After Partial Bladder Outlet Obstruction
Junlong Z,et al.
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 24, 1064-1064 (2018)
Chunlin Chen et al.
Acta pharmaceutica Sinica. B, 5(1), 55-61 (2015-11-19)
The purpose of this study is to investigate the expression of major potassium channel subtypes in the brain of chronical mild stress (CMS) rats and reveal the effects of fluoxetine on the expression of these channels. Rats were exposed to
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