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WH0008518M3

Monoclonal Anti-IKBKAP antibody produced in mouse

Name: Monoclonal Anti-IKBKAP antibody produced in mouse
Brand: SIGMA

clone 6G9, purified immunoglobulin, buffered aqueous solution

Synonym(s):

DKFZp781H1425, DYS, ELP1, FD, IKAP, IKI3, TOT1, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD04118553

Conjugate:

unconjugated

Clone:

6G9, monoclonal

Application:

ELISA, IHC (p), WB

Citations:

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Properties

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

6G9, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

ELISA: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, western blot: 1-5 μg/mL

isotype

IgG1κ

GenBank accession no.

NM_003640

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... IKBKAP(8518)

Description

Immunogen

IKBKAP (NP_003631, 1242 a.a. ~ 1331 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
VLFLFEFDEQGRELQKAFEDTLQLMERSLPEIWTLTYQQNSATPVLGPNSTANSIMASYQQQKTSVPVLDAELFIPPKINRRTQWKLSLL

Biochem/physiol Actions

The protein encoded by this gene is a scaffold protein and a regulator for 3 different kinases involved in proinflammatory signaling. This encoded protein can bind NF-kappa-B-inducing kinase (NIK) and IKKs through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia. (provided by RefSeq)

Physical form

Solution in phosphate buffered saline, pH 7.4

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Regulatory Information

常规特殊物品

低风险生物材料

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Certificates of Analysis (COA)

Lot/Batch Number

KC171-6G9

06244-6G9

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Phosphatidylserine increases IKBKAP levels in a humanized knock-in IKBKAP mouse model.

Bochner R, et.al

Human Molecular Genetics, 22(14), 2785-2794 (2013)

Dimerization of elongator protein 1 is essential for Elongator complex assembly.

Xu H, et.al

Proceedings of the National Academy of Sciences of the USA, 112(34), 10697-10702 (2015)

Global Trade Item Number

SKU	GTIN
WH0008518M3-100UG	04061831649093