50139-U
LiChrospher® RP-18 endcapped (5 µm) HPLC Columns
L × I.D. 25 cm × 4.6 mm, HPLC Column
Synonym(s):
TM=["LiChrospher"] C18 HPLC column
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About This Item
UNSPSC Code:
41115700
eCl@ss:
32110501
NACRES:
SB.52
L × i.d.:
25 cm × 4.6 mm
Particle size:
5 μm
Matrix active group:
C18 (RP18), C18 (octadecyl) phase
Pore size:
100 Å
Matrix:
octadecyl, silica particle platform, fully porous particle
Product Name
LiChrospher® RP-18 HPLC Column, 5 μm particle size, L × I.D. 25 cm × 4.6 mm, endcapped
material
stainless steel column
Quality Segment
agency
suitable for USP L1
product line
LiChrospher®
feature
endcapped
manufacturer/tradename
LiChrospher®
packaging
1 ea of
extent of labeling
21% Carbon loading
parameter
≤65 °C temperature, ≤70 °C temp. range, 400 bar pressure (5801 psi)
technique(s)
HPLC: suitable
L × I.D.
25 cm × 4.6 mm
surface area
350 m2/g
matrix
octadecyl, silica particle platform, fully porous particle
matrix active group
C18 (RP18), C18 (octadecyl) phase
particle size
5 μm
pore size
100 Å
operating pH
2-7.5
application(s)
food and beverages
separation technique
reversed phase
General description
LiChrosorb® RP-18 HPLC Column are classified as L1 USP columns and primarily used for reversed-phase HPLC of neutral, acidic and weak basic compounds. The totally porous irregular particles ensure reliable results.
LiChrospher® RP-18 HPLC column is an incredibly reliable and highly versatile, traditionally manufactured spherical silica-based support, designed for reversed-phase chromatography of acidic, neutral and weakly basic compounds - substances frequently found in all analytical fields. The optimal selectivity and performance of the column ensure that these parameters remain constant from batch to batch and from year to year.
Application
- HPLC-UV and GC-MS Methods for Determination of Chlorambucil and Valproic Acid in Plasma for Further Exploring a New Combined Therapy of Chronic Lymphocytic Leukemia.: This study illustrates the efficiency of the LiChrospher® RP-18 HPLC Column in a novel approach to analyzing the pharmacokinetics of chlorambucil and valproic acid, providing critical data for potential combined therapy options in treating chronic lymphocytic leukemia (Lipska et al., 2021).
- Rapid Determination of Metronidazole and 2-Hydroxymetronidazole in Murine Blood Plasma.: Utilizes the LiChrospher® RP-18 HPLC Column to establish a rapid and accurate method for the analysis of metronidazole and its metabolites in blood plasma, enhancing the understanding of its pharmacological impacts and supporting more effective therapeutic strategies (Zemanova et al., 2022).
- Application of chemometric approach for development and validation of high performance liquid chromatography method for estimation of ropinirole hydrochloride.: Demonstrates the application of the LiChrospher® RP-18 HPLC Column in optimizing a chemometrically enhanced method for the determination of ropinirole hydrochloride, aimed at improving treatment strategies for Parkinsons disease (Fatima et al., 2019).
- Application of an HPLC-MS/MS method for Teicoplanin drug substance and related impurities, part 2: Identity assignment of related impurities.: This research highlights the capability of the LiChrospher® RP-18 HPLC Column in detailed impurity profiling of teicoplanin, critical for maintaining drug purity and efficacy in antibiotic treatments (Tengattini et al., 2019).
Legal Information
LiChrosorb is a registered trademark of Merck KGaA, Darmstadt, Germany
LiChrospher is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 50139-U | 04061833515051 |