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Merck
CN

502219

Dabsyl chloride

Synonym(s):

4-(Dimethylamino)azobenzene-4′-sulfonyl chloride, 4-(4-Dimethylaminophenylazo)benzenesulfonyl chloride, DABS-Cl, Dabsyl chloride

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About This Item

Linear Formula:
(CH3)2NC6H4N=NC6H4SO2Cl
CAS Number:
56512-49-3
Molecular Weight:
323.80
EC Number:
260-235-1
UNSPSC Code:
12352200
PubChem Substance ID:
24873345
Beilstein/REAXYS Number:
3064095
MDL number:
MFCD00007444

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InChI key

VTVWTPGLLAELLI-WUKNDPDISA-N

InChI

1S/C14H14ClN3O2S/c1-18(2)13-7-3-11(4-8-13)16-17-12-5-9-14(10-6-12)21(15,19)20/h3-10H,1-2H3/b17-16+

SMILES string

CN(C)c1ccc(cc1)\N=N\c2ccc(cc2)S(Cl)(=O)=O

grade

derivatization grade ((HPLC))

form

solid

packaging

pkg of 500 mg

mp

185 °C (dec.) (lit.)

storage temp.

room temp

General description

Dabsyl chloride (4-dimethylaminoazobenzene-4′-sulfonyl chloride) is a chromophoric labeling reagent used in HPLC for derivatizing amino acids. It reacts freely with all amino acids in order to form dabsyl amino acids, which are photostable and can be seen on a thin-layer chromatographic plate.

Other Notes

Discover LiChropur reagents ideal for HPLC or LC-MS analysis

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H314

Hazard Classifications

Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
LC24646V
LC24641V
LC21794V
LC17700V
LC14263V

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Chromophoric labeling of amino acids with 4-dimethylaminoazobenzene-4'-sulfonyl chloride.
J K Lin and J Y Chang.
Analytical Chemistry, 47 (9), 1634-1638 (1975)
Jansen, E.H.J., et al.
Journal of Chromatography A, 553 (1991)
M Takahashi et al.
Journal of chromatography. B, Biomedical sciences and applications, 688(2), 197-203 (1997-01-24)
To elucidate the factors involved in dry skin and the skin damage caused by UV light, it is necessary to analyze small amounts of stratum corneum to determine amino acid contents. A new assay method for this purpose is described.
K Sormiachi et al.
Journal of chromatography. B, Biomedical applications, 664(2), 435-439 (1995-02-17)
A high-performance liquid chromatographic method was modified for the determination of hydroxyproline in cultured cells derived from rat liver. First, the primary amino group in the cell hydrolysate was blocked with o-phthalaldehyde, then the secondary amino group was derivatized with
Reversed-phase high-performance liquid chromatography separation of dimethylaminoazobenzene sulfonyl- and dimethylaminoazobenzene thiohydantoin-amino acid derivatives for amino acid analysis and microsequencing studies at the picomole level.
v
Analytical Biochemistry, 178(1), 107-117 (1989)
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