58150AST
CHIRALPAK® AGP (5 μm) HPLC Columns
L × I.D. 10 cm × 4 mm, HPLC Column
Synonym(s):
AGP Chiral Chromatography Column
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About This Item
UNSPSC Code:
41115700
eCl@ss:
32110501
NACRES:
SB.52
Product Name
CHIRALPAK® AGP HPLC Column, 5 μm particle size, L × I.D. 10 cm × 4 mm
material
stainless steel column
Quality Level
Agency
suitable for USP L41
product line
CHIRALPAK®
packaging
pkg of 1 ea
manufacturer/tradename
CHIRALPAK®
parameter
137 bar pressure (2000 psi)
20-30 °C temperature
40 °C max. temp.
technique(s)
HPLC: suitable
L × I.D.
10 cm × 4 mm
matrix
fully porous particle
matrix active group
glycoprotein, alpha1- phase
particle size
5 μm
operating pH
2-8
separation technique
chiral
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General description
Hermansson described the use of natural proteins immobilized onto a silica support for chiral separations in 1983 (1). Proteins contain a large number of chiral centers of one configuration, and many other sites that contribute to the general retention process. CHIRALPAK AGP has the broadest range of selectivity of all protein phases currently available. CHIRALPAK AGP phase uses α1-acid glycoprotein (AGP) as the chiral selector immobilized on spherical 5 μm silica particles. Bonded AGP is a very stable protein that tolerates pure organic solvents, elevated temperatures and pH values from 4 to 7. Operated in reversed-phase mode, CHIRALPAK AGP column separates enantiomers of an extremely broad range of drug substances, such as acids, amines and neutral compounds. The enantioselectivity and retention can easily be regulated by mobile phase pH and ionic strength, and the nature and concentration of the organic modifier.
Features:
(1) Hermansson, J. Direct liquid chromatographic resolution of racemic drugs using a1-acid glycoprotein as the chiral stationary phase. J. Chromatogr. A, 1983, 269, 71-80.
Features:
- Direct reversed phase resolution of chiral molecules
- Stable with a variety of organic modifiers
- Available in analytical and semi-preparative sizes
(1) Hermansson, J. Direct liquid chromatographic resolution of racemic drugs using a1-acid glycoprotein as the chiral stationary phase. J. Chromatogr. A, 1983, 269, 71-80.
Application
- Enantiomeric methadone quantitation on real post-mortem dried matrix spots samples: Comparison of liquid chromatography and supercritical fluid chromatography coupled to mass spectrometry.: This study explores the application of enantioselective liquid chromatography techniques, including the use of CHIRALPAK® AGP, for the quantitation of methadone enantiomers on dried matrix spots, contributing to forensic toxicology and analytical chemistry (Mueller et al., 2021).
- Enantiomeric Separation of Dioxopromethazine and its Stereoselective Pharmacokinetics in Rats by HPLC-MS/MS.: This research demonstrates the utility of chiral stationary phases, such as CHIRALPAK® AGP, for separating enantiomers of pharmaceutical compounds, providing insights into stereoselective pharmacokinetics critical for drug development and clinical pharmacology (Lun et al., 2021).
- Evaluation of R- (-) and S- (+) Clenbuterol enantiomers during a doping cycle or continuous ingestion of contaminated meat using chiral liquid chromatography by LC-TQ-MS.: This article details the application of chiral liquid chromatography, potentially involving CHIRALPAK® AGP columns, to distinguish between therapeutic use and contamination sources of clenbuterol, addressing challenges in sports doping analysis (Dolores et al., 2019).
Legal Information
CHIRALPAK is a registered trademark of Daicel Corp.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Chromatograms
application for HPLC
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