229857

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Showing 31-60 of 83 results for "229857" within Papers

Engineering a fibrocartilage spectrum through modulation of aggregate redifferentiation.

Meghan K Murphy et al.

Cell transplantation, 24(2), 235-245 (2014-01-02)

Expanded costochondral cells provide a clinically relevant cell source for engineering both fibrous and hyaline articular cartilage. Expanding chondrocytes in a monolayer results in a shift toward a proliferative, fibroblastic phenotype. Three-dimensional aggregate culture may, however, be used to recover

Bone regeneration in a massive rat femur defect through endochondral ossification achieved with chondrogenically differentiated MSCs in a degradable scaffold.

Noriko Harada et al.

Biomaterials, 35(27), 7800-7810 (2014-06-24)

Mesenchymal stem cells (MSCs) are multipotent cells capable of proliferating and differentiating into several lineages. In regenerative medicine, their potential as a resource for tissue-replacement therapy is receiving much attention. However, transplanting MSCs to repair larger bone defects in animal

Insulin, ascorbate, and glucose have a much greater influence than transferrin and selenous acid on the in vitro growth of engineered cartilage in chondrogenic media.

Alexander D Cigan et al.

Tissue engineering. Part A, 19(17-18), 1941-1948 (2013-04-03)

The primary goal of this study was to characterize the response of chondrocyte-seeded agarose constructs to varying concentrations of several key nutrients in a chondrogenic medium, within the overall context of optimizing the key nutrients and the placement of nutrient

GFP labelling and epigenetic enzyme expression of bone marrow-derived mesenchymal stem cells from bovine foetuses.

P Díaz et al.

Research in veterinary science, 99, 120-128 (2015-02-01)

Mesenchymal stem cells (MSC) are multipotent progenitor cells defined by their ability to self-renew and give rise to differentiated progeny. Since MSC from adult tissues represent a promising source of cells for a wide range of cellular therapies, there is

Methylation and demethylation of intermediates selenide and methylselenol in the metabolism of selenium.

Yuki Ohta et al.

Toxicology and applied pharmacology, 226(2), 169-177 (2007-11-09)

All nutritional selenium sources are transformed into the assumed common intermediate selenide for the syntheses of selenoproteins for utilization and/or of selenosugar for excretion. Methylselenol [monomethylselenide, MMSe] is the assumed intermediate leading to other methylated metabolites, dimethylselenide (DMSe) and trimethylselenonium

Image-based evaluations of distribution and cytotoxicity of Irinotecan (CPT-11) in a multi-compartment micro-cell coculture device.

Hidenari Nakayama et al.

Journal of bioscience and bioengineering, 117(6), 756-762 (2014-01-01)

We recently developed a polydimethylsiloxane (PDMS)-based three-compartment microfluidic cocultivation device enabling real-time interactions of different cell populations as an advanced physiologically-relevant cell-based assay. This device had valves and small magnetic stirrer-based internal pumps for easy and flexible perfusion operations. In

Meniscus is more susceptible than cartilage to catabolic and anti-anabolic effects of adipokines.

J F Nishimuta et al.

Osteoarthritis and cartilage, 23(9), 1551-1562 (2015-04-29)

This study compared the effects on cartilage and meniscus matrix catabolism and biosynthesis of several adipokines implicated in osteoarthritis (OA). Bovine cartilage and meniscus explants were cultured for 1 or 9 days in serum-free medium alone or with 0.02, 0.2

Prevention of carboplatin-induced resistance in human ovarian tumor xenografts by selenite.

Paula B Caffrey et al.

Anticancer research, 33(10), 4249-4254 (2013-10-15)

We have been exploring a prevention approach to the problem of drug resistance which develops during ovarian cancer chemotherapy. We have previously described an in vivo model of the development of resistance to the chemotherapy drug cisplatin in xenografts, and

Spatially restricted hyaluronan production by Has2 drives epithelial tubulogenesis in vitro.

Priscilla Soulié et al.

American journal of physiology. Cell physiology, 307(8), C745-C759 (2014-08-29)

Generation of branched tubes from an epithelial bud is a fundamental process in development. We hypothesized that induction of hyaluronan synthase (Has) and production of hyaluronan (HA) drives tubulogenesis in response to morphogenetic cytokines. Treatment of J3B1A mammary cells with

Ropp RC et al.

Encyclopedia of the Alkaline Earth Compounds null

Reduced filaggrin expression is accompanied by increased Staphylococcus aureus colonization of epidermal skin models.

V van Drongelen et al.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 44(12), 1515-1524 (2014-10-30)

Atopic dermatitis is an inflammatory skin disease that is characterized by a reduced skin barrier function, reduced filaggrin (FLG) expression as well as increased colonization by Staphylococcus aureus. This study focused on the possible involvement of FLG in epidermal colonization

Manufacturing and use of human placenta-derived mesenchymal stromal cells for phase I clinical trials: establishment and evaluation of a protocol.

Nina Ilić et al.

Vojnosanitetski pregled, 71(7), 651-659 (2014-08-12)

Mesenchymal stromal cells (MSCs) have been utilised in many clinical trials as an experimental treatment in numerous clinical settings. Bone marrow remains the traditional source tissue for MSCs but is relatively hard to access in large volumes. Alternatively, MSCs may

Comparative Labeling of Equine and Ovine Multipotent Stromal Cells With Superparamagnetic Iron Oxide Particles for Magnetic Resonance Imaging In Vitro.

Henriette Jülke et al.

Cell transplantation, 24(6), 1111-1125 (2013-12-18)

The purpose of this study was to evaluate the use of three different superparamagnetic iron oxide (SPIO) particles for labeling of ovine and equine bone marrow (BM)-derived multipotent stromal cells (MSCs) in vitro. MSCs were obtained from five adult sheep

Selenization of ovalbumin by dry-heating in the presence of selenite: effect on protein structure and antioxidant activity.

Can-Peng Li et al.

Food chemistry, 148, 209-217 (2013-11-23)

Ovalbumin (OVA) was selenized by dry-heating in the presence of selenite, and the structural characteristics and improved antioxidant activity of selenized OVA (Se-OVA) were investigated. Although the change of the secondary structure in the OVA molecule by selenization was small

Metalloido-porins: Essentiality of Nodulin 26-like intrinsic proteins in metalloid transport.

Benjamin Pommerrenig et al.

Plant science : an international journal of experimental plant biology, 238, 212-227 (2015-08-11)

Metalloids are a group of physiologically important elements ranging from the essential to the highly toxic. Arsenic, antimony, germanium, and tellurium are highly toxic to plants themselves and to consumers of metalloid-contaminated plants. Boron, silicon, and selenium fulfill essential or

Generation of selenium-enriched rice with enhanced grain yield, selenium content and bioavailability through fertilisation with selenite.

Yu-Dong Wang et al.

Food chemistry, 141(3), 2385-2393 (2013-07-23)

To fulfill the natural human needs of selenium, selenium biofortification has been carried out in rice (Oryza sativa) in recent years. Despite some improvements have been made, the increase of selenium content in rice was still limited and a large

Damage to fetal bovine ovarian tissue caused by cryoprotectant exposure and vitrification is mitigated during tissue culture.

Lara Mouttham et al.

Journal of assisted reproduction and genetics, 32(8), 1239-1250 (2015-08-08)

The objective of this study is to characterize the impact of exposure to cryoprotectants followed by vitrification on primordial follicle survival and activation using a fetal bovine model. In the first study, fetal bovine cortical pieces were exposed to cryoprotectants

Parathyroid hormone enhances hematopoietic expansion via upregulation of cadherin-11 in bone marrow mesenchymal stromal cells.

Hisayuki Yao et al.

Stem cells (Dayton, Ohio), 32(8), 2245-2255 (2014-03-22)

Parathyroid hormone (PTH) stimulates hematopoiesis in mouse models. The involvement of osteoblasts in this process has been well investigated; however, the effects of PTH on human hematopoiesis and bone marrow mesenchymal stromal cells (BM-MSCs) are unclear. Here, we show that

Toll-like receptor-mediated responses by placental Hofbauer cells (HBCs): a potential pro-inflammatory role for fetal M2 macrophages.

Omar M Young et al.

American journal of reproductive immunology (New York, N.Y. : 1989), 73(1), 22-35 (2014-10-28)

Microbial-driven responses in placenta are linked with adverse pregnancy outcomes. The role of Toll-like receptor (TLR) function in Hofbauer cells (HBCs) and fetal macrophages of the placental villous core remains understudied. Flow cytometry and immunohistochemistry (IHC) were used to establish

Role of bone marrow mesenchymal stem cells in L-arg-induced acute pancreatitis: effects and possible mechanisms.

Guojian Yin et al.

International journal of clinical and experimental pathology, 8(5), 4457-4468 (2015-07-21)

Mesenchymal stem cells (MSCs) have shown an obvious protective effect on systemic inflammation. The purpose of this study is to assess the effect and possible mechanism of bone marrow MSCs (bmMSCs) on acute pancreatitis (AP). BmMSCs of SD rats were

Intracavernous delivery of clonal mesenchymal stem cells restores erectile function in a mouse model of cavernous nerve injury.

Ji-Kan Ryu et al.

The journal of sexual medicine, 11(2), 411-423 (2013-11-21)

Recently, much attention has focused on stem cell therapy; bone marrow-derived stem cells (BMSCs) are one of the most studied mesenchymal stem cells used in the field of erectile dysfunction (ED). However, a major limitation for the clinical application of

Repetitive allogeneic intraarticular injections of synovial mesenchymal stem cells promote meniscus regeneration in a porcine massive meniscus defect model.

D Hatsushika et al.

Osteoarthritis and cartilage, 22(7), 941-950 (2014-05-06)

A new strategy is required in order to regenerate a meniscus for extensive defects. Synovial mesenchymal stem cells (MSCs) are an attractive cell source for meniscus regeneration due to their high proliferation and chondrogenic potential. We examined the effect of

Metabolic differences and similarities of selenium in blood and brain of the rat following the administration of different selenium compounds.

Z J Wang et al.

Biological trace element research, 33, 135-143 (1992-04-01)

A common intermediate, i.e., selenite, was found in the serum of the rat; the maximum levels occurred 3 h after administration independent of chemical forms. This indicates that both the reduction of selenate to selenite, and oxidation of seleno-dl-methionine to

Post firing visualisation of fingerprint on spent cartridge cases.

R K Bentsen et al.

Science & justice : journal of the Forensic Science Society, 36(1), 3-8 (1996-01-01)

A considerable range of techniques is available to visualise latent fingerprints on smooth surfaces. Published methods and those developed or modified in the authors' laboratory have been evaluated for spent cartridge cases. The most suitable were found to be vacuum

Fact versus artifact: avoiding erroneous estimates of sulfated glycosaminoglycan content using the dimethylmethylene blue colorimetric assay for tissue-engineered constructs.

C H Zheng et al.

European cells & materials, 29, 224-236 (2015-04-22)

The 1,9-dimethylmethylene blue (DMMB) assay is widely used to quantify sulfated glycosaminoglycan (sGAG) contents of engineered tissues, culture media, tissue samples and bodily fluids, but the assay is subject to interference from polyanions such as hyaluronic acid (HA), DNA and

The protective role of glutathione peroxidase in apoptosis induced by reactive oxygen species.

Y Kayanoki et al.

Journal of biochemistry, 119(4), 817-822 (1996-04-01)

Selenium-dependent glutathione peroxidase (GPx) plays a protective role in oxidative stress-induced apoptosis. In this study, we demonstrated that MDBK cells, a bovine renal epithelial cell line, exhibited internucleosomal DNA fragmentation characteristic of apoptotic cell death under selenium-deficient conditions with lower

Antigenotoxic properties of selenium: studies in the wing spot test in Drosophila.

M Rizki et al.

Environmental and molecular mutagenesis, 37(1), 70-75 (2001-02-15)

The genotoxic activity of three selenium compounds (sodium selenite, sodium selenate, and selenious acid) and the antigenotoxic effects of sodium selenite in combination with the chromium compound potassium dichromate were studied using the wing spot test of Drosophila melanogaster. This

Disialoganglioside-specific human natural killer cells are effective against drug-resistant neuroblastoma.

Diana Seidel et al.

Cancer immunology, immunotherapy : CII, 64(5), 621-634 (2015-02-26)

The disialoganglioside GD2 is a well-established target antigen for passive immunotherapy in neuroblastoma (NB). Despite the recent success of passive immunotherapy with the anti-GD2 antibody ch14.18 and cytokines, treatment of high-risk NB remains challenging. We expanded the approach of GD2-specific

Selenium metabolite levels in human urine after dosing selenium in different chemical forms.

R Hasunuma et al.

Bulletin of environmental contamination and toxicology, 51(5), 756-763 (1993-11-01)

Inhibition by selenium of DNA and RNA synthesis in normal and malignant human cells in vitro.

F I Abdullaev et al.

Cancer letters, 65(1), 43-49 (1992-07-31)

Several studies have demonstrated differences between normal and malignant cells in their sensitivity to various effects of selenite. We have compared the effect of selenite on DNA and RNA synthesis in two pairs of normal and malignant human cell lines.

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