34865

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Showing 1-30 of 246 results for "34865" within Papers

Production of all trans-beta-carotene by using impinging flow of supercritical carbon dioxide anti-solvent pulverization.

Yi-Chen Shen et al.

Journal of chromatography. A, 1270, 1-8 (2012-11-28)

This work investigated column elution chromatography coupled with supercritical anti-solvent precipitation to produce carotenoid rich microsized particulates from microalgal Dunaliella salina species. The extract contained carotenoids ranging from 61.3 mg/g(salina) to 72.5 mg/g(salina) using ultrasonic stirred ethyl ether or tetrahydrofuran

Ionic complex of risedronate with positively charged deoxycholic acid derivative: evaluation of physicochemical properties and enhancement of intestinal absorption in rats.

Jin Woo Park et al.

Archives of pharmacal research, 37(12), 1560-1569 (2013-11-21)

Risedronate is widely used clinically to treat osteoporosis, Paget's disease, hypercalcemia, bone metastasis, and multiple myeloma. However, its oral efficacy is restricted due to its low bioavailability and severe gastrointestinal adverse effects. This study was designed to evaluate the effect

Interstitial modification of palladium nanoparticles with boron atoms as a green catalyst for selective hydrogenation.

Chun Wong Aaron Chan et al.

Nature communications, 5, 5787-5787 (2014-12-20)

Lindlar catalysts comprising of palladium/calcium carbonate modified with lead acetate and quinoline are widely employed industrially for the partial hydrogenation of alkynes. However, their use is restricted, particularly for food, cosmetic and drug manufacture, due to the extremely toxic nature

Toward prediction of alkane/water partition coefficients.

Anita Toulmin et al.

Journal of medicinal chemistry, 51(13), 3720-3730 (2008-06-19)

Partition coefficients were measured for 47 compounds in the hexadecane/water ( P hxd) and 1-octanol/water ( P oct) systems. Some types of hydrogen bond acceptor presented by these compounds to the partitioning systems are not well represented in the literature

Performance of structured lipids incorporating selected phenolic and ascorbic acids.

Eliza Gruczynska et al.

Food chemistry, 173, 778-783 (2014-12-04)

Conditions applied during frying require antioxidant which is stable at these conditions and provides protection for frying oil and fried food. Novel structured lipids containing nutraceuticals and antioxidants were formed by enzymatic transesterification, exploring canola oil and naturally occurring antioxidants

Adsorption of water from aqueous acetonitrile on silica-based stationary phases in aqueous normal-phase liquid chromatography.

Jan Soukup et al.

Journal of chromatography. A, 1374, 102-111 (2014-12-30)

Excess adsorption of water from aqueous acetonitrile mobile phases was investigated on 16 stationary phases using the frontal analysis method and coulometric Karl-Fischer titration. The stationary phases include silica gel and silica-bonded phases with different polarities, octadecyl and cholesterol, phenyl

Determination of heptylphysostigmine in plasma by high-performance liquid chromatography with electrochemical detection.

L K Unni et al.

Journal of chromatography, 573(2), 275-281 (1992-01-17)

An analytical method was developed with sensitivity to detect clinically significant concentrations of heptylphysostigmine (HP), a new physostigmine derivative with potent and long-lasting inhibitory activity on cholinesterase. HP, an experimental drug for Alzheimer disease, was measured in human plasma by

Weak coordination of neutral S- and O-donor proximal ligands to a ferrous porphyrin nitrosyl. Characterization of 6-coordinate complexes at low T.

G G Martirosyan et al.

Journal of inorganic biochemistry, 121, 129-133 (2013-02-05)

The interaction of the S- and O-donor ligands tetrahydrothiophen (THT) and tetrahydrofuran (THF) with the ferrous nitrosyl complex Fe(TTP)(NO) (TTP(2-) is meso-tetra-p-tolyl-porphyrinatodianion) was studied at various temperatures both in solid state and solution using electronic and infrared absorption spectroscopy. Upon

Characterizing synthetic polymers and additives using new ionization methods for mass spectrometry.

Tarick J El-Baba et al.

Rapid communications in mass spectrometry : RCM, 28(11), 1175-1184 (2014-04-25)

New inlet and vacuum ionization methods provide advantages of specificity, simplicity and speed for the analysis of synthetic polymers and polymer additives directly from surfaces such as fibers using mass spectrometry (MS) on different commercial mass spectrometers (Waters SYNAPT G2

Effect of extrusion on phytochemical profiles in milled fractions of black rice.

Huihui Ti et al.

Food chemistry, 178, 186-194 (2015-02-24)

The phytochemical profile and antioxidant activities of unprocessed and extruded milled fractions of black rice were investigated. Extrusion increased the free phenolics, anthocyanins and oxygen radical absorbance capacity (ORAC) and decreased the bound forms. The total phenolics, anthocyanins and ORAC

Recognitive nano-thin-film composite beads for the enantiomeric resolution of the metastatic breast cancer drug aminoglutethimide.

Porkodi Kadhirvel et al.

Journal of chromatography. A, 1358, 93-101 (2014-07-22)

Straightforward crushing and sieving bulk polymeric R-aminoglutethimide-imprinted materials were prepared by classical free radical polymerization, whereas nano thin walled grafted imprinted materials were prepared using RAFT mediated control polymerization technique. A stoichiometric non-covalent approach based on a triply hydrogen bonding

Comparative method validation for closantel determination in cattle and sheep milk according to European Union Volume 8 and Veterinary International Conference on Harmonization guidelines.

Mathias Devreese et al.

Journal of chromatography. A, 1353, 106-113 (2014-03-25)

A specific and sensitive LC-MS/MS method was developed for quantitative determination of closantel in bovine and ovine colostrum and tank milk. Sample preparation consisted of extracting milk samples with acetonitrile/acetone (80/20, v/v) followed by SPE clean-up with Oasis mixed anion

Design, synthesis and structure-activity relationship studies of novel and diverse cyclooxygenase-2 inhibitors as anti-inflammatory drugs.

Shigeo Hayashi et al.

Journal of enzyme inhibition and medicinal chemistry, 29(6), 846-867 (2014-02-13)

Because of the pivotal role of cyclooxygenase (COX) in the inflammatory processes, non-steroidal anti-inflammatory drugs (NSAIDs) that suppress COX activities have been used clinically for the treatment of inflammatory diseases/syndromes; however, traditional NSAIDs exhibit serious side-effects such as gastrointestinal damage

Aberrant repair initiated by mismatch-specific thymine-DNA glycosylases provides a mechanism for the mutational bias observed in CpG islands.

Ibtissam Talhaoui et al.

Nucleic acids research, 42(10), 6300-6313 (2014-04-03)

The human thymine-DNA glycosylase (TDG) initiates the base excision repair (BER) pathway to remove spontaneous and induced DNA base damage. It was first biochemically characterized for its ability to remove T mispaired with G in CpG context. TDG is involved

Delivery of antisense oligonucleotides using poly(alkylene oxide)-poly(propylacrylic acid) graft copolymers in conjunction with cationic liposomes.

Lavanya Y Peddada et al.

Journal of controlled release : official journal of the Controlled Release Society, 194, 103-112 (2014-09-07)

The clinical application of gene silencing is hindered by poor stability and low delivery efficiency of naked oligonucleotides. Here, we present the in vitro and in vivo behaviors of a rationally designed, ternary, self-assembled nanoparticle complex, consisting of an anionic

Tritiation and characterization of several suicide substrate enzyme inactivators.

Judith A Egan et al.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 94, 302-305 (2014-10-12)

Methods are presented to tritiate the enzyme inhibitors pargyline and caracemide.

Synthesis, structure, spectral characterization, electrochemistry and evaluation of antibacterial potentiality of a novel oxime-based palladium(II) compound.

Nirmalya Bandyopadhyay et al.

European journal of medicinal chemistry, 89, 59-66 (2014-12-03)

The title monomeric Pd(II) compound, [Pd(L)(Cl)], was synthesized in moderate yield out of the reaction of equimolar proportion of Na2[PdCl4] and 3-[(5-bromo-2-hydroxy-benzylidene)-hydrazono]-butan-2-one oxime (LH) in tetrahydrofuran milieu. LH is a 1:1 Schiff-base condensate of 2,3-butanedionemonoxime monohydrazone and 5-bromosalicylaldehyde. [Pd(L)(Cl)] has

Assessment of the relative performance of a confined impinging jets mixer and a multi-inlet vortex mixer for curcumin nanoparticle production.

Shing Fung Chow et al.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(2), 462-471 (2014-07-16)

The relative performance of two specially designed mixers for nanoparticle production, namely, two-stream confined impinging jets with dilution mixer (CIJ-D-M) and four-stream multi-inlet vortex mixer (MIVM), was evaluated using the model compound, curcumin (CUR), under defined conditions of varying mixing

Large defect-tailored composite scaffolds for in vivo bone regeneration.

Alfredo Ronca et al.

Journal of biomaterials applications, 29(5), 715-727 (2014-06-22)

The discovery of new strategies to repair large segmental bone defects is currently an open challenge for worldwide clinicians. In the treatment of critical-sized bone defects, an alternative strategy to traditional bone grafting is always more frequently the use of

Synthesis of variants of Marfey's reagent having d-amino acids as chiral auxiliaries and liquid-chromatographic enantioseparation of (RS)-Mexiletine in spiked plasma: assessment and comparison with L-amino acid analogs.

Ravi Bhushan et al.

Journal of chromatography. A, 1379, 43-50 (2015-01-13)

Five d-amino acids have been used for the first time to synthesize chiral derivatizing reagents (as variants of Marfey's reagent) by nucleophilic displacement of one of the fluorine atoms in 1,5-difluoro-2,4-dinitrobenzene as against the literature reports on application of only

Total, elastic, and inelastic cross sections for positron and electron collisions with tetrahydrofuran.

Luca Chiari et al.

The Journal of chemical physics, 138(7), 074301-074301 (2013-03-01)

We present total, elastic, and inelastic cross sections for positron and electron scattering from tetrahydrofuran (THF) in the energy range between 1 and 5000 eV. Total cross sections (TCS), positronium formation cross sections, the summed inelastic integral cross sections (ICS)

The potential of follicle-stimulating hormone peptide-modified triptolide-loaded nanoparticles to induce a mouse model of premature ovarian insufficiency.

Xiu-Ying Chen et al.

International journal of nanomedicine, 10, 2765-2774 (2015-04-22)

The use of triptolide (TP) is limited by its poor water solubility and severe toxicity. In this study, we developed an active drug delivery system (TP-loaded nanoparticles) that could help improve the water solubility of TP and decrease its toxicity.

Enhanced mobility of fullerene (C60) nanoparticles in the presence of stabilizing agents.

Yonggang Wang et al.

Environmental science & technology, 46(21), 11761-11769 (2012-09-15)

Experimental and mathematical modeling studies were performed to examine the effects of stabilizing agents on the transport and retention of fullerene nanoparticles (nC(60)) in water-saturated quartz sand. Three stabilizing systems were considered: naturally occurring compounds known to stabilize nanoparticles (Suwannee

Synthetic routes to tetrahydrofuran, tetrahydropyran, and spiroketal units of polyether antibiotics and a survey of spiroketals of other natural products.

Boivin TLB.

Tetrahedron, 43(15), 3309-3362 (1987)

Nanonization of curcumin by antisolvent precipitation: process development, characterization, freeze drying and stability performance.

Deepak Yadav et al.

International journal of pharmaceutics, 477(1-2), 564-577 (2014-12-03)

The present work aims to investigate applicability of antisolvent precipitation method for preparation of nanosized curcumin and to control their characteristics by determining the influence of process and solvents on solid-state properties of curcumin nanoparticles. Effects of different experimental parameters

Tissue-specific gene delivery via nanoparticle coating.

Todd J Harris et al.

Biomaterials, 31(5), 998-1006 (2009-10-24)

The use of biomaterials for gene delivery can potentially avoid many of the safety concerns with viral gene delivery. However, the efficacy of polymeric gene delivery methods is low, particularly in vivo. One significant concern is that the interior and

Antitumor activity of PEGylated biodegradable nanoparticles for sustained release of docetaxel in triple-negative breast cancer.

Giuseppe Palma et al.

International journal of pharmaceutics, 473(1-2), 55-63 (2014-07-06)

With the aim to find novel therapeutical approaches for triple-negative breast cancer (TNBC) treatment, we have developed a powder for i.v. injection based on cyclodextrins and docetaxel (DTX)-loaded polyethyleneglycol-poly(epsilon-caprolactone) nanoparticles (DTX-NPs). Nanoparticles are designed to concentrate at tumor level by

Bioluminescent liquid light guide pad biosensor for indoor air toxicity monitoring.

Evgeni Eltzov et al.

Analytical chemistry, 87(7), 3655-3661 (2015-03-17)

Indoor air pollution became a recent concern found to be oftentimes worse than outdoor air quality. We developed a tool that is cheap and simple and enables continuous monitoring of air toxicity. It is a biosensor with both a nondisposable

Development of an ultraperformance liquid chromatography-tandem mass spectrometry method for the analysis of perfluorinated compounds in fish and Fatty food.

Stephen W C Chung et al.

Journal of agricultural and food chemistry, 62(25), 5805-5811 (2014-06-06)

This paper reports the development of a method for the quantitative analysis of perfluorinated compounds (PFCs), including C6-C14 perfluorinated carboxylic acids (PFCAs) and C4-C12 perfluorinated sulfonates (PFSAs), in fish and fatty foods by ultraperformance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-ESI-MS/MS)

Centrifugal partition chromatography elution gradient for isolation of sesquiterpene lactones and flavonoids from Anvillea radiata.

Emilie Destandau et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 985, 29-37 (2015-02-04)

An innovative procedure coupling pressurized solvent extraction and centrifugal partition chromatography (CPC) used in linear gradient elution mode was developed to isolate two pure germacranolides (9α-hydroxyparthenolide and 9β-hydroxyparthenolide) and to separate flavonoids (nepetin, isorhamnetin and jaceosidin) and chlorophyll pigments from

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