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Showing 31-60 of 3396 results for "34885" within Papers
Ana Freitas et al.
Journal of the science of food and agriculture, 95(1), 44-52 (2014-05-24)
The industrial processing of pineapple generates a high quantity of by-products. To reduce the environmental impact of these by-products and the inherent cost of their treatment, it is important to characterise and valorise these products, converting them into high added
Marie Soukupová et al.
Experimental neurology, 257, 39-49 (2014-04-29)
The alterations in GABA release have not yet been systematically measured along the natural course of temporal lobe epilepsy. In this work, we analyzed GABA extracellular concentrations (using in vivo microdialysis under basal and high K(+)-evoked conditions) and loss of
Francesco De Pascali et al.
Biochemistry, 53(22), 3679-3688 (2014-04-25)
Ischemia-reperfusion injury is accompanied by endothelial hypoxia and reoxygenation that trigger oxidative stress with enhanced superoxide generation and diminished nitric oxide (NO) production leading to endothelial dysfunction. Oxidative depletion of the endothelial NO synthase (eNOS) cofactor tetrahydrobiopterin can trigger eNOS
Ayşegül Doğan et al.
Materials science & engineering. C, Materials for biological applications, 44, 246-253 (2014-10-05)
Scaffold-based bone defect reconstructions still face many challenges due to their inadequate osteoinductive and osteoconductive properties. Various biocompatible and biodegradable scaffolds, combined with proper cell type and biochemical signal molecules, have attracted significant interest in hard tissue engineering approaches. In
Meiling Ye et al.
Nanoscale research letters, 9(1), 642-642 (2014-12-19)
Nano-sized particles are known to interfere with drug-metabolizing cytochrome P450 (CYP) enzymes, which can be anticipated to be a potential source of unintended adverse reactions, but the mechanisms underlying the inhibition are still not well understood. Herein we report a
Liang Sun et al.
Nature communications, 5, 5746-5746 (2014-12-18)
Co-crystallization of polymers with different configurations/tacticities provides access to materials with enhanced performance. The stereocomplexation of isotactic poly(L-lactide) and poly(D-lactide) has led to improved properties compared with each homochiral material. Herein, we report the preparation of stereocomplex micelles from a
Lukas Rambousek et al.
Drug and alcohol dependence, 139, 138-144 (2014-04-15)
Methamphetamine (METH) abuse is a growing health problem worldwide, and METH use during pregnancy not only endangers the mother's health but also the developing fetus. To provide better insight into these risks, we performed the following experiments. First, we investigated
Nagham Asp et al.
Biochimica et biophysica acta, 1843(9), 1987-1996 (2014-04-22)
The ErbB3 receptor is an important regulator of cell growth and carcinogenesis. Among breast cancer patients, up to 50-70% have ErbB3 overexpression and 20-30% show overexpressed or amplified ErbB2. ErbB3 has also been implicated in the development of resistance to
Tatyana Kanyshkova et al.
Molecular and cellular neurosciences, 61, 110-122 (2014-06-11)
The polygenic origin of generalized absence epilepsy results in dysfunction of ion channels that allows the switch from physiological asynchronous to pathophysiological highly synchronous network activity. Evidence from rat and mouse models of absence epilepsy indicates that altered Ca(2+) channel
Ping Xu et al.
Biotechnology progress, 30(6), 1457-1468 (2014-08-01)
A unique and nontraditional approach using glutamine and asparagine supplements for CHO-glutamine synthetase (GS) cell lines was studied. In our experiments, we found that a decrease in pH and an increase in cell death occurred in production phase of a
Tyson J Smyth et al.
Biochimica et biophysica acta, 1838(11), 2954-2965 (2014-08-08)
Small endogenous vesicles called exosomes are beginning to be explored as drug delivery vehicles. The in vivo targets of exosomes are poorly understood; however, they are believed to be important in cell-to-cell communication and may play a prominent role in
Huijuan Zhang et al.
Biomaterials, 37, 353-366 (2014-12-03)
Artesunate (AS) is an iron-dependent drug, which has been used extensively as anti-malarial drugs worldwide with no obvious side effects. Recently, studies have shown that AS also possess profound cytotoxicity against tumor cells. However, simultaneous delivery of hydrophobic AS and
Gaëlle Vacher et al.
International journal of pharmaceutics, 482(1-2), 61-67 (2014-12-03)
We describe here the establishment and first characterization of a co-culture model of human epithelial sublingual cells (HO-1-u-1 cell line) and human dendritic cells derived from human peripheral blood monocytes (PBMC). Cell culture conditions for HO-1-u-1 cells were optimized. First
Shi Yun Leong et al.
PLoS pathogens, 11(3), e1004686-e1004686 (2015-03-10)
Human Enterovirus 71 (EV71) commonly causes Hand, Foot and Mouth Disease in young children, and occasional occurrences of neurological complications can be fatal. In this study, a high-throughput cell-based screening on the serine/threonine kinase siRNA library was performed to identify
Yashpal S Chhonker et al.
Fitoterapia, 97, 34-42 (2014-05-21)
A sensitive, selective, and rapid high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed for the quantification of rohitukine in rat plasma. HPLC was performed using a Symmetry-Shield C18 (5 μ, 4.6 × 150 mm) column, and isocratic elution with
Mingming Gao et al.
PloS one, 10(3), e0119784-e0119784 (2015-03-15)
High-fat diet (HFD) has been applied to a variety of inbred mouse strains to induce obesity and obesity related metabolic complications. In this study, we determined HFD induced development of metabolic disorders on outbred female CD-1 mice in a time
Cecilia Janér et al.
Neonatology, 107(1), 27-33 (2014-10-11)
Respiratory distress due to inadequate lung liquid clearance is a significant problem in infants delivered late preterm or early term, especially by elective cesarean delivery (CD). Lung liquid clearance depends on epithelial ion transport and in animals is induced by
Li Zhao et al.
Biochemical and biophysical research communications, 459(4), 643-649 (2015-03-12)
Prolonged benzidine exposure is a known cause of urothelial carcinoma (UC). Benzidine-induced epithelial-to-mesenchymal transition (EMT) is critically involved in cell malignant transformation. The role of ERK1/2 in regulating benzidine-triggered EMT has not been investigated. This study was to investigate the
Massimiliano Sgroi et al.
Water research, 70, 174-183 (2014-12-22)
Full-scale experiments to evaluate N-nitrosodimethylamine (NDMA) formation and attenuation were performed within an advanced indirect potable reuse (IPR) treatment system, which includes, sequentially: chloramination for membrane fouling control, microfiltration (MF), reverse osmosis (RO), ultraviolet irradiation with hydrogen peroxide (UV/H₂O₂), final
L A Maranho et al.
Environmental research, 134, 353-365 (2014-09-10)
A set of "early warning responses", measured as biomarkers of exposure and effect, was applied in the marine bioindicator Hediste diversicolor, in a way to assess the environmental quality of sediment affected by pharmaceutical contamination. Sublethal responses were determined in
Dominik Lermen et al.
PloS one, 9(8), e105401-e105401 (2014-08-21)
Technical progress has simplified tasks in lab diagnosis and improved quality of test results. Errors occurring during the pre-analytical phase have more negative impact on the quality of test results than errors encountered during the total analytical process. Different infrastructures
Erik Hanff et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 970, 44-52 (2014-09-23)
A specific, sensitive and fast LC-MS/MS method with positive electrospray ionization for the quantitative determination of nitrite in human plasma is reported. Added [(15)N]nitrite served as the internal standard (IS). Endogenous nitrite and IS were converted to their S-nitrosoglutathione (GSNO)
Jianqing Ruan et al.
Chemical research in toxicology, 27(6), 1030-1039 (2014-05-20)
Pyrrolizidine alkaloids (PAs) are natural toxins widely distributed in plants. The toxic potencies of different PAs vary significantly. PAs are mono- or diesters of necine acids with a necine base. On the basis of the necine bases, PAs are classified
Prasanta Saini et al.
Parasitology international, 63(5), 717-728 (2014-07-11)
A bio-assay guided fractionation and purification approach was used to examine in vitro antifilarial activities of the crude methanolic extract of Nyctanthes arbortristis as well as fractions and isolated compound. From ethyl-acetate fraction we isolated and identified a triterpenoid compound
Szende Vancea et al.
Journal of pharmaceutical and biomedical analysis, 98, 417-423 (2014-07-10)
A liquid chromatography coupled with tandem mass spectrometry method for the quantification of the antispasmodic drug drotaverine in human plasma was developed and validated according to the current bioanalytical guidelines. The internal standard used was imipramine. The separation was performed
Bin Xu et al.
Talanta, 132, 245-251 (2014-12-06)
A new isotope-dilution liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for determination of sulfur mustard (SM) has been developed using a direct chemical derivatization method by nucleophile potassium thioacetate (PTA) in aqueous solution. The reaction conditions for derivatization, such as reaction
Y Sultan et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 971, 89-93 (2014-10-02)
The performance of five different C18 chromatography analytical columns with different lengths, particle sizes and porosities were compared for analysis of ochratoxin A (OTA) in fungal cultures and raisin samples. Chromatographic parameters including retention time, limit of detection, limit of
Masaru Sugita et al.
The AAPS journal, 16(5), 1119-1127 (2014-07-30)
This study sought to understand the reasons for the bioinequivalence of a newly developed generic product of pioglitazone hydrochloride and to improve its formulation so that it is equivalent to that of the reference listed drug (RLD). In this clinical
Min Yang et al.
PloS one, 9(12), e115052-e115052 (2015-01-01)
Intercropping systems could increase crop diversity and avoid vulnerability to biotic stresses. Most studies have shown that intercropping can provide relief to crops against wind-dispersed pathogens. However, there was limited data on how the practice of intercropping help crops against
S M Ahmad et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 969, 35-41 (2014-08-27)
This study proposes a new analytical methodology for the determination of trace levels of testosterone (T) and epitestosterone (E) in urine matrices using bar adsorptive microextraction combined with liquid desorption followed by high-performance liquid chromatography with diode array detection (BAμE-LD/HPLC-DAD).
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