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Showing 31-60 of 3396 results for "34885" within Papers
S Torok et al.
British journal of pharmacology, 172(4), 1148-1163 (2014-11-05)
The clinical effects of anti-angiogenic agents remain controversial. Therefore, elucidating the pharmacological properties of these compounds is a pivotal issue. The effects of treatment with sunitinib on tumour and normal tissues of mice bearing C-26 adenocarcinoma cells were analysed by
Erica Hoffer et al.
Therapeutic drug monitoring, 37(2), 214-219 (2014-08-28)
Liquid chromatography with mass spectrometry (LC-MS/MS) is the method of choice for the determination of everolimus whole blood concentrations but is not always available. Therefore, immunoassays have been developed for clinical monitoring of everolimus. In previous studies, the Quantitative Microsphere
Minchul Seo et al.
Nature communications, 5, 5217-5217 (2014-10-29)
Lentiviral short hairpin RNA (shRNA)-mediated genetic screening is a powerful tool for identifying loss-of-function phenotype in mammalian cells. Here, we report the identification of 91 cell migration-regulating genes using unbiased genome-wide functional genetic selection. Individual knockdown or cDNA overexpression of
B Rasti et al.
Journal of liposome research, 24(2), 99-105 (2013-10-09)
This study presents the application of the response surface methodology (design) to develop an optimal preparation condition (independent variables) namely shear rate (600-1000 rpm), mixing time (30-60 min), and sonication time (10-20 min) for polyunsaturated fatty acids (docosahexaenoic acid and
Lisa M Arendt et al.
Breast cancer research : BCR, 16(5), 453-453 (2014-10-16)
Lineage tracing studies in mice have revealed the localization and existence of lineage-restricted mammary epithelial progenitor cells that functionally contribute to expansive growth during puberty and differentiation during pregnancy. However, extensive anatomical differences between mouse and human mammary tissues preclude
Maaike Kockx et al.
PloS one, 9(10), e111186-e111186 (2014-10-28)
Dynamins are fission proteins that mediate endocytic and exocytic membrane events and are pharmacological therapeutic targets. These studies investigate whether dynamin II regulates constitutive protein secretion and show for the first time that pharmacological inhibition of dynamin decreases secretion of
James A Carroll et al.
Journal of virology, 89(4), 2388-2404 (2014-12-17)
Gliosis is often a preclinical pathological finding in neurodegenerative diseases, including prion diseases, but the mechanisms facilitating gliosis and neuronal damage in these diseases are not understood. To expand our knowledge of the neuroinflammatory response in prion diseases, we assessed
Yan Chen et al.
Die Pharmazie, 69(7), 506-511 (2014-07-31)
Ginger has been widely used as healthy food condiment as well as traditional Chinese medicine since antiquity. Multiple potentials of ginger for treatment of various ailments have been revealed. However, the biological half-life of 6-gingerol (a principal pungent ingredient of
Brent D Van Rite et al.
Cancer investigation, 31(8), 505-510 (2013-10-03)
The L-methioninase-annexin V/selenomethionine enzyme prodrug system, designed to target the tumor vasculature and release the methylselenol anticancer drug in the tumor, was tested in mice with implanted MBA-MB-231 breast tumors. This therapy was able to cause a reduction in the
Hui-Wen Gu et al.
Analytica chimica acta, 848, 10-24 (2014-09-30)
β-blockers are the first-line therapeutic agents for treating cardiovascular diseases and also a class of prohibited substances in athletic competitions. In this work, a smart strategy that combines three-way liquid chromatography-mass spectrometry (LC-MS) data with second-order calibration method based on
Abdulselam Ertas et al.
Pharmaceutical biology, 53(3), 334-339 (2014-10-22)
In Turkey, Veronica species (Plantaginaceae) have been used as a diuretic and for wound healing in traditional medicine. To examine the fatty acid and essential oil profiles, the antioxidant, anticholinesterase, antimicrobial, and DNA damage effects of Veronica thymoides P.H. Davis
Kamal K Gupta et al.
Journal of biomedical materials research. Part A, 102(8), 2600-2612 (2013-09-17)
Hybrid nanofibers of poly(lactic acid) and polycaprolactone have been developed by embedding cancerous drug through electrospinning technique. The composition of polymer has been varied to check the compositional effect on properties. The quality of nanofibers has been testified through surface
Muhammad Munawar Hayat et al.
Journal of ethnopharmacology, 156, 347-352 (2014-09-16)
Folk herbal practitioners of the Cholistan desert claim Farsetia hamiltonii Royle (Brassicaceae) to treat diabetes, oxidative damages, diarrhea, fever, and abdominal cramps. The aim of this study was to scientifically find the potential of Farsetia hamiltonii in treating diabetes and
Lijun Zhu et al.
The Journal of pharmacy and pharmacology, 66(11), 1534-1551 (2014-06-20)
Naftopidil (NAF) is a chiral compound with two enantiomers (R(+)-NAF and S(-)-NAF) and is used as a racemic mixture in clinical practice. This study aims to investigate the metabolism of NAF enantiomers in pooled human liver microsomes (HLMs) and cytochrome
Marwa Ahmed et al.
Chirality, 26(11), 754-763 (2014-03-08)
New affinity monolithic capillary columns of 150 µm internal diameter were prepared in situ fused glass capillary via either immobilization or encapsulation of Candida antarctica lipase B (CALB) on or within polymer monoliths, respectively. The immobilized lipase-based monoliths were prepared
Huiyuan Wang et al.
Molecular pharmaceutics, 11(8), 2600-2611 (2014-01-11)
Our objective was to design a polymeric micelle-based doxorubicin and lapatinib combination therapy for treating multidrug resistant (MDR) breast cancers. Poly(ethylene glycol)-block-poly(2-methyl-2-benzoxycarbonylpropylene carbonate) (PEG-PBC) polymers were synthesized for preparing doxorubicin and lapatinib loaded micelles using a film dispersion method. Micelles
Zhiqian Liu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 978-979, 95-102 (2014-12-23)
Polar lipids (PLs) are a significant functional component of milk that are difficult to quantitate. A simple method for comprehensive identification and quantitative analysis of all essential PL species using bovine milk is described. The lipid fraction was extracted by
Hyeon-Ju Kim et al.
Oncology reports, 33(2), 699-704 (2014-12-02)
Siegesbeckia glabrescens (SG) Makino (Compositae) has been used as a traditional medicine for the treatment of allergic and inflammatory diseases. In the present study, we report the effects and molecular mechanism of an ethanolic extract of SG on cell proliferation
J Brent Friesen et al.
Journal of chromatography. A, 1377, 55-63 (2014-12-30)
Rational solvent system selection for countercurrent chromatography and centrifugal partition chromatography technology (collectively known as countercurrent separation) studies continues to be a scientific challenge as the fundamental questions of comparing polarity range and selectivity within a solvent system family and
Elham Aghaee et al.
Journal of molecular modeling, 20(10), 2446-2446 (2014-09-16)
A computational approach to designing a peptide-based ligand for the purification of human serum albumin (HSA) was undertaken using molecular docking and molecular dynamics (MD) simulation. A three-step procedure was performed to design a specific ligand for HSA. Based on
Ola A Saleh et al.
Journal of chromatographic science, 52(6), 539-546 (2013-06-08)
A stability-indicating reversed-phase high-performance liquid chromatographic assay procedure has been developed and validated for riluzole in the presence of alkaline and oxidative degradation products. The liquid chromatographic separation was achieved and compared isocratically on C18 Zorbax ODS and Poroshell 120
Zhaozhou Li et al.
Journal of pharmaceutical and biomedical analysis, 98, 210-220 (2014-06-20)
The molecularly imprinted polymers (MIPs) were prepared by an oxidation-reduction polymerization system using a non-covalent molecularly imprinting strategy with hypericin as the template, acrylamide as the functional monomer and pentaerythritol triacrylate as the cross-linker in the porogen of acetone. The
Ján Vančo et al.
PloS one, 9(10), e109901-e109901 (2014-10-22)
The gold(I) mixed-ligand complexes involving O-substituted derivatives of 9-deazahypoxanthine (HLn) and triphenylphosphine (PPh3) with the general formula [Au(Ln)(PPh3)] (1-5) were prepared and thoroughly characterized by elemental analysis, FT-IR and multinuclear NMR spectroscopy, ESI+ mass spectrometry, single crystal X-ray (HL5 and
Mehmet Cansev et al.
Neurobiology of aging, 36(1), 344-351 (2014-08-26)
Fortasyn Connect (FC) is a specific nutrient combination designed to target synaptic dysfunction in Alzheimer's disease by providing neuronal membrane precursors and other supportive nutrients. The aim of the present study was to investigate the effects of FC on hippocampal
Nandi J Reddy et al.
Clinical toxicology (Philadelphia, Pa.), 48(10), 967-973 (2011-01-05)
Ethylene glycol, diethylene glycol and methanol are widely available chemicals and are found in a variety of common household products including antifreeze, windshield washer fluid, brake fluid and lubricants. Following ingestion of these glycols and methanol, patients frequently develop an
Miguel Angel García-Sevillano et al.
Analytical and bioanalytical chemistry, 406(24), 5853-5865 (2014-07-30)
The biochemical response of mice (Mus musculus) to acute subcutaneous inorganic-mercury exposure was assessed over a 14-day period by analyzing cytosolic extracts of the liver, the kidneys, and blood plasma. Integrated metallomic and metabolomic approaches using elemental and molecular-mass spectrometry
Michael J Wright et al.
Clinical chemistry, 61(3), 505-513 (2015-01-22)
LC-MS/MS with multiple reaction monitoring (MRM) is a powerful tool for quantifying target analytes in complex matrices. However, the technique lacks selectivity when plasma free metanephrines are measured. We propose the use of multistage fragmentation (MRM(3)) to improve the analytical
Yuanyuan Ma et al.
Journal of chromatography. A, 1356, 64-81 (2014-07-14)
A large variety of phenolic compounds, including phenolic acids (hydroxybenzoic acids, hydroxycinnamic acids, and their esters), stilbenes (trans-resveratrol and trans-piceatannol), flavan-3-ols (e.g., (-)-epicatechin, (+)-catechin, and their polymers {the proanthocyanidins, PACs}), other flavonoids (e.g., isoflavones, flavanols, and flavones, etc.) and biflavonoids
Camilla Lööv et al.
Journal of neurotrauma, 32(4), 244-251 (2014-08-05)
Traumatic brain injury (TBI) is a heterogeneous disease, and the discovery of diagnostic and prognostic TBI biomarkers is highly desirable in order to individualize patient care. We have previously published a study in which we identified possible TBI biomarkers by
A T Mata et al.
Food chemistry, 176, 455-464 (2015-01-28)
The presence of mycotoxins in food samples has been widely studied as well as its impact in human health, however, information about its distribution in the environment is scarce. An analytical method comprising a solid phase extraction procedure followed by
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