50058

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Showing 1-30 of 673 results for "50058" within Papers

An aberrant leukotriene A4 hydrolase-proline-glycine-proline pathway in the pathogenesis of chronic obstructive pulmonary disease.

J Michael Wells et al.

American journal of respiratory and critical care medicine, 190(1), 51-61 (2014-05-31)

Chronic neutrophilic inflammation is a hallmark in the pathogenesis of chronic obstructive pulmonary disease (COPD) and persists after cigarette smoking has stopped. Mechanisms involved in this ongoing inflammatory response have not been delineated. We investigated changes to the leukotriene A4

In vivo and in vitro nuclear magnetic resonance spectroscopy as a tool for investigating hepatobiliary disease: a review of H and P MRS applications.

Shahid A Khan et al.

Liver international : official journal of the International Association for the Study of the Liver, 25(2), 273-281 (2005-03-23)

Nuclear magnetic resonance (NMR) spectroscopy is a non-invasive technique, which allows the study of cellular biochemistry and metabolism. It is a diverse research tool, widely used by biochemists to investigate pathophysiological processes in vitro and, more recently, by physicians to

Synthetic conantokin peptides potently inhibit N-methyl-D-aspartate receptor-mediated currents of retinal ganglion cells.

Luoxiu Huang et al.

Journal of neuroscience research, 92(12), 1767-1774 (2014-07-22)

Retinal ganglion cells (RGCs), which are the sole output neurons of the retina, express N-methyl-D-aspartate receptors (NMDARs), rendering these cells susceptible to glutamate excitotoxicity, with implications for loss of normal RGC excitatory responses in disorders such as glaucoma and diabetic

A sensitive and reproducible in vivo imaging mouse model for evaluation of drugs against late-stage human African trypanosomiasis.

Hollie Burrell-Saward et al.

The Journal of antimicrobial chemotherapy, 70(2), 510-517 (2014-10-10)

To optimize the Trypanosoma brucei brucei GVR35 VSL-2 bioluminescent strain as an innovative drug evaluation model for late-stage human African trypanosomiasis. An IVIS® Lumina II imaging system was used to detect bioluminescent T. b. brucei GVR35 parasites in mice to

Analysis of free amino acids in natural waters by liquid chromatography-tandem mass spectrometry.

Zuo Tong How et al.

Journal of chromatography. A, 1370, 135-146 (2014-12-03)

This paper reports a new analytical method for the analysis of 18 amino acids in natural waters using solid-phase extraction (SPE) followed by liquid chromatography-electrospray tandem mass spectrometry (LC-MS/MS) operated in multiple reaction monitoring mode. Two different preconcentration methods, solid-phase

Plumbagin elicits differential proteomic responses mainly involving cell cycle, apoptosis, autophagy, and epithelial-to-mesenchymal transition pathways in human prostate cancer PC-3 and DU145 cells.

Jia-Xuan Qiu et al.

Drug design, development and therapy, 9, 349-417 (2015-01-23)

Plumbagin (PLB) has exhibited a potent anticancer effect in preclinical studies, but the molecular interactome remains elusive. This study aimed to compare the quantitative proteomic responses to PLB treatment in human prostate cancer PC-3 and DU145 cells using the approach

Neonatal NMDA receptor blockade disrupts spike timing and glutamatergic synapses in fast spiking interneurons in a NMDA receptor hypofunction model of schizophrenia.

Kevin S Jones et al.

PloS one, 9(10), e109303-e109303 (2014-10-08)

The dysfunction of parvalbumin-positive, fast-spiking interneurons (FSI) is considered a primary contributor to the pathophysiology of schizophrenia (SZ), but deficits in FSI physiology have not been explicitly characterized. We show for the first time, that a widely-employed model of schizophrenia

Integrated 'omics analysis for studying the microbial community response to a pH perturbation of a cellulose-degrading bioreactor culture.

Amy A Boaro et al.

FEMS microbiology ecology, 90(3), 802-815 (2014-10-08)

Integrated 'omics have been used on pure cultures and co-cultures, yet they have not been applied to complex microbial communities to examine questions of perturbation response. In this study, we used integrated 'omics to measure the perturbation response of a

Mass fragmentography of 5-hydroxytryptophol and 5-methoxytryptophol in human cerebrospinal fluid.

H C Curtius et al.

Journal of chromatography, 112, 523-531 (1975-10-29)

A specific and very sensitive method for the determination of 5-hydroxy-tryptophol (5-HTOL) and 5-methoxytryptophol (5-MTOL) in extracts from human cerebrospinal fluid (CSF) involving the use of mass fragmentography and pentafluoropriopionyl derivatives is described. 5-HTOL and 5-MTOL were determined in human

Pantothenate and pantetheine antagonize the antitubercular activity of pyrazinamide.

Nicholas A Dillon et al.

Antimicrobial agents and chemotherapy, 58(12), 7258-7263 (2014-09-24)

Pyrazinamide (PZA) is a first-line tuberculosis drug that inhibits the growth of Mycobacterium tuberculosis via an as yet undefined mechanism. An M. tuberculosis laboratory strain that was auxotrophic for pantothenate was found to be insensitive to PZA and to the

Biomarkers probed in saliva by surface plasmon resonance imaging coupled to matrix-assisted laser desorption/ionization mass spectrometry in array format.

Johana Musso et al.

Analytical and bioanalytical chemistry, 407(5), 1285-1294 (2014-12-20)

Detection of protein biomarkers is of major interest in proteomics. This work reports the analysis of protein biomarkers directly from a biological fluid, human saliva, by surface plasmon resonance imaging coupled to mass spectrometry (SPRi-MS), using a functionalized biochip in

Rostro-caudal inhibition of hindlimb movements in the spinal cord of mice.

Vittorio Caggiano et al.

PloS one, 9(6), e100865-e100865 (2014-06-26)

Inhibitory neurons in the adult mammalian spinal cord are known to locally modulate afferent feedback--from muscle proprioceptors and from skin receptors--to pattern motor activity for locomotion and postural control. Here, using optogenetic tools, we explored how the same population of

Molecular and in vivo characterization of cancer-propagating cells derived from MYCN-dependent medulloblastoma.

Zai Ahmad et al.

PloS one, 10(3), e0119834-e0119834 (2015-03-19)

Medulloblastoma (MB) is the most common malignant pediatric brain tumor. While the pathways that are deregulated in MB remain to be fully characterized, amplification and/or overexpression of the MYCN gene, which is has a critical role in cerebellar development as

Leucine-rich repeat kinase 2 modulates neuroinflammation and neurotoxicity in models of human immunodeficiency virus 1-associated neurocognitive disorders.

Jenna M Puccini et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(13), 5271-5283 (2015-04-04)

Leucine-rich repeat kinase 2 (LRRK2) is the single most common genetic cause of both familial and sporadic Parkinson's disease (PD), both of which share pathogenetic and neurologic similarities with human immunodeficiency virus 1 (HIV-1)-associated neurocognitive disorders (HAND). Pathologic LRRK2 activity

Molecular basis for the improvement in muscle metaboreflex and mechanoreflex control in exercise-trained humans with chronic heart failure.

Ligia M Antunes-Correa et al.

American journal of physiology. Heart and circulatory physiology, 307(11), H1655-H1666 (2014-10-12)

Previous studies have demonstrated that muscle mechanoreflex and metaboreflex controls are altered in heart failure (HF), which seems to be due to changes in cyclooxygenase (COX) pathway and changes in receptors on afferent neurons, including transient receptor potential vanilloid type-1

SPAD aptasensor for the detection of circulating protein biomarkers.

Laura Pasquardini et al.

Biosensors & bioelectronics, 68, 500-507 (2015-01-31)

The need for decentralized clinical tests together with the concept of time and cost saving are pushing the development of portable, miniaturized, compact biosensors with diagnostic and prognostic purpose. Here, we propose an innovative detection system based on a Single

Resveratrol enhances palmitate-induced ER stress and apoptosis in cancer cells.

Cristina Rojas et al.

PloS one, 9(12), e113929-e113929 (2014-12-02)

Palmitate, a saturated fatty acid (FA), is known to induce toxicity and cell death in various types of cells. Resveratrol (RSV) is able to prevent pathogenesis and/or decelerate the progression of a variety of diseases. Several in vitro and in

Isolation & identification of bacteria for the treatment of brown crab (Cancer pagurus) waste to produce chitinous material.

C Harkin et al.

Journal of applied microbiology, 118(4), 954-965 (2015-02-04)

To isolate bacteria from soil for microbial pretreatment of brown crab (Cancer pagurus) shell waste and the production of chitin. Isolates were screened for protease enzymes and acid production in order to facilitate the removal of protein and calcium carbonate

Novel biosensors based on optimized glycine oxidase.

Elena Rosini et al.

The FEBS journal, 281(15), 3460-3472 (2014-06-14)

Glycine is involved in several physiological functions, e.g. as a neurotransmitter in the central nervous system, and sarcosine has been identified as a differential metabolite greatly enhanced during prostate cancer progression and metastasis. Glycine oxidase from Bacillus subtilis (GO) was

Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding.

Patrick R Visperas et al.

The Biochemical journal, 465(1), 149-161 (2014-10-08)

Zeta-chain associated protein of 70 kDa (ZAP-70) and spleen tyrosine kinase (Syk) are non-receptor tyrosine kinases that are essential for T-cell and B-cell antigen receptor signalling respectively. They are recruited, via their tandem-SH2 (Src-homology domain 2) domains, to doubly phosphorylated immunoreceptor

Liposome encapsulated soy lecithin and cholesterol can efficiently replace chicken egg yolk in human semen cryopreservation medium.

Srinivas Mutalik et al.

Systems biology in reproductive medicine, 60(3), 183-188 (2014-03-25)

Cryopreservation of spermatozoa plays a significant role in reproductive medicine and fertility preservation. Chicken egg yolk is used as an extender in cryopreservation of human spermatozoa using glycerol egg yolk citrate (GEYC) buffered medium. Even though 50% survival of spermatozoa

F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner.

Kanae Yumimoto et al.

The Journal of clinical investigation, 125(2), 621-635 (2015-01-03)

The gene encoding F-box protein FBXW7 is frequently mutated in many human cancers. Although most previous studies have focused on the tumor-suppressive capacity of FBXW7 in tumor cells themselves, we determined that FBXW7 in the host microenvironment also suppresses cancer

Glycinergic inhibition to the medial nucleus of the trapezoid body shows prominent facilitation and can sustain high levels of ongoing activity.

Florian Mayer et al.

Journal of neurophysiology, 112(11), 2901-2915 (2014-09-05)

Neurons in the medial nucleus of the trapezoid body (MNTB) are well known for their prominent excitatory inputs, mediated by the calyx of Held. Less attention has been paid to the prominent inhibitory inputs that MNTB neurons also receive. Because

Drosophila DOCK family protein sponge regulates the JNK pathway during thorax development.

Kazushige Morishita et al.

Cell structure and function, 39(2), 113-124 (2014-10-15)

The dedicator of cytokinesis (DOCK) family proteins that are conserved in a wide variety of species are known as DOCK1-DOCK11 in mammals. The Sponge (Spg) is a Drosophila counterpart to the mammalian DOCK3. Specific knockdown of spg by pannir-GAL4 or

Simultaneous determination of total nitrogen and total phosphorus in environmental waters using alkaline persulfate digestion and ion chromatography.

Brian M De Borba et al.

Journal of chromatography. A, 1369, 131-137 (2014-12-03)

An ion chromatography (IC) method was developed for the simultaneous determination of total nitrogen and total phosphorus after alkaline persulfate digestion. This study takes advantage of advances in construction of high-resolution, high-capacity anion-exchange columns that can better tolerate the matrices

Designing a recombinant chimeric construct contain MUC1 and HER2 extracellular domain for prediagnostic breast cancer.

Elaheh Gheybi et al.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(11), 11489-11497 (2014-08-17)

Breast cancer is the most common cancer among women in the world. One of the approaches for diagnosis of breast cancer is detection of its tumor-associated markers. Mucin 1 (MUC1), a tumor-associated antigen, is a transmembrane glycoprotein expressed by normal

Preimplantation embryo development in the mouse requires the latency of TRP53 expression, which is induced by a ligand-activated PI3 kinase/AKT/MDM2-mediated signaling pathway.

X L Jin et al.

Biology of reproduction, 80(2), 286-294 (2008-10-17)

A universal response to cellular stress is the expression of transformation-related protein 53 (TRP53). This transcription factor reduces cell proliferation and/or survival and is classed as a tumour suppressor protein. Several stresses (including culture) cause increased TRP53 expression in blastocysts

Natural and disease-specific autoantibodies in chronic obstructive pulmonary disease.

N I Daffa et al.

Clinical and experimental immunology, 180(1), 155-163 (2014-12-04)

Autoimmunity may contribute to the pathogenesis of chronic obstructive pulmonary disease (COPD). Studies have identified disease-specific autoantibodies (DSAAbs) in COPD patients, but natural autoantibodies (NAAbs) may also play a role. Previous studies have concentrated on circulating autoantibodies, but lung-associated autoantibodies

The human peptidylarginine deiminases type 2 and type 4 have distinct substrate specificities.

Constance Assohou-Luty et al.

Biochimica et biophysica acta, 1844(4), 829-836 (2014-03-07)

Human peptidylarginine deiminases (hPADs) have been implicated in several diseases, particularly in rheumatoid arthritis. Since hPAD2 and hPAD4 are the isotypes expressed in the inflamed joints of RA patients and protein citrullination by PADs has been proposed to play a

Ventral tegmental area neurotensin signaling links the lateral hypothalamus to locomotor activity and striatal dopamine efflux in male mice.

Christa M Patterson et al.

Endocrinology, 156(5), 1692-1700 (2015-03-04)

Projections from the lateral hypothalamic area (LHA) innervate components of the mesolimbic dopamine (MLDA) system, including the ventral tegmental area (VTA) and nucleus accumbens (NAc), to modulate motivation appropriately for physiologic state. Neurotensin (NT)-containing LHA neurons respond to multiple homeostatic

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