650501

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TLR3 engagement induces IRF-3-dependent apoptosis in androgen-sensitive prostate cancer cells and inhibits tumour growth in vivo.

Guido Gambara et al.

Journal of cellular and molecular medicine, 19(2), 327-339 (2014-12-03)

Toll-like receptors (TLRs) are a family of highly conserved transmembrane proteins expressed in epithelial and immune cells that recognize pathogen associated molecular patterns. Besides their role in immune response against infections, numerous studies have shown an important role of different

Using SILAC proteomics to investigate the effect of the mycotoxin, alternariol, in the human H295R steroidogenesis model.

Shewit Kalayou et al.

Cell biology and toxicology, 30(6), 361-376 (2014-11-25)

The mycotoxin alternariol (AOH) is an important contaminant of fruits and cereal products. The current study sought to address the effect of a non-toxic AOH concentration on the proteome of the steroidogenic H295R cell model. Quantitative proteomics based on stable

S100A6 and its extracellular targets in Wharton's jelly of healthy and preeclamptic patients.

E Jurewicz et al.

Placenta, 35(6), 386-391 (2014-04-22)

In this work we compared the level, localization and binding partners of a calcium binding protein, S100A6, in extracellular matrix of Wharton's jelly of healthy and preeclamptic patients. Studies were performed on the umbilical cords taken from 10 newborns delivered

Constant pressure mode extended simple gradient liquid chromatography system for micro and nanocolumns.

Jozef Šesták et al.

Journal of chromatography. A, 1350, 68-71 (2014-05-28)

Performing gradient liquid chromatography at constant pressure instead of constant flow rate has serious potential for shortening the analysis time and increasing the productivity of HPLC instruments that use gradient methods. However, in the constant pressure mode the decreasing column

GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment.

Ernesto Cortes et al.

EMBO reports, 20(1) (2018-12-13)

The mechanical properties of the tumor microenvironment are emerging as attractive targets for the development of therapies. Tamoxifen, an agonist of the G protein-coupled estrogen receptor (GPER), is widely used to treat estrogen-positive breast cancer. Here, we show that tamoxifen

Comparison of a novel TiO₂/diatomite composite and pure TiO₂ for the purification of phosvitin phosphopeptides.

Yang Zhang et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 960, 52-58 (2014-05-03)

A novel TiO2/diatomite composite (TD) was prepared and then characterized by scanning electron microscope (SEM) and Fourier Transform Infrared (FTIR). The results of SEM showed that after modification, the porous surface of diatomite was covered with TiO2. Both diatomite and

The effect of polymeric excipients on the physical properties and performance of amorphous dispersions: Part I, free volume and glass transition.

Jinjiang Li et al.

Pharmaceutical research, 32(2), 500-515 (2014-08-12)

To investigate the structural effect of polymeric excipients on the behavior of free volume of drug-polymer dispersions in relation to glass transition. Two drugs (indomethacin and ketoconazole) were selected to prepare amorphous dispersions with PVP, PVPVA, HPC, and HPMCAS through

High throughput proteomic analysis of the secretome in an explant model of articular cartilage inflammation.

Abigail L Clutterbuck et al.

Journal of proteomics, 74(5), 704-715 (2011-03-01)

This study employed a targeted high-throughput proteomic approach to identify the major proteins present in the secretome of articular cartilage. Explants from equine metacarpophalangeal joints were incubated alone or with interleukin-1beta (IL-1β, 10ng/ml), with or without carprofen, a non-steroidal anti-inflammatory

The B-vitamins in malnutrition with alcoholism. A model of intervitamin relationships.

D K Dastur et al.

The British journal of nutrition, 36(2), 143-159 (1976-09-01)

1. The B-vitamin status of fifty-nine patients, mainly from the lower socio-economic classes in Bombay, with a history of chronic malnutrition, and of alcoholism of 1-5-20 years' duration, was studied before and during treatment, and in relation to their clinical

Junctional adhesion molecule A promotes epithelial tight junction assembly to augment lung barrier function.

Leslie A Mitchell et al.

The American journal of pathology, 185(2), 372-386 (2014-12-02)

Epithelial barrier function is maintained by tight junction proteins that control paracellular fluid flux. Among these proteins is junctional adhesion molecule A (JAM-A), an Ig fold transmembrane protein. To assess JAM-A function in the lung, we depleted JAM-A in primary

Detection of factor XIII-A is a valuable tool for distinguishing dendritic cells and tissue macrophages in granuloma annulare and necrobiosis lipoidica.

D Töröcsik et al.

Journal of the European Academy of Dermatology and Venereology : JEADV, 28(8), 1087-1096 (2013-11-19)

Factor XIII subunit A (FXIII-A) is used as a diagnostic marker in a wide range of dermatological diseases ranging from inflammatory lesions to malignancies, although neither the cell types responsible for its expression nor the mechanism(s) resulting in its local

IL32 is progressively expressed in mycosis fungoides independent of helper T-cell 2 and helper T-cell 9 polarization.

Hanako Ohmatsu et al.

Cancer immunology research, 2(9), 890-900 (2014-06-19)

Mycosis fungoides, the most common type of cutaneous T-cell lymphoma (CTCL), is characterized by a helper T-cell 2 (Th2) skewing with a mature CD4(+) memory T-cell phenotype. Using skin samples from patients with mycosis fungoides (n = 21), healthy volunteers

Maltose and isomaltose in uremic plasma following icodextrin administration.

R A Burke et al.

Advances in peritoneal dialysis. Conference on Peritoneal Dialysis, 14, 120-123 (2000-01-29)

The presence of mixed disaccharides (maltose and isomaltose) in plasma from uremic patients has been previously investigated using gel-permeation chromatography. However, this method is unable to separate maltose (linked alpha-1-4) from isomaltose (linked alpha-1-6). We describe an alternative method using

Progression of muscle histopathology but not of spliceopathy in myotonic dystrophy type 2.

Rosanna Cardani et al.

Neuromuscular disorders : NMD, 24(12), 1042-1053 (2014-08-21)

Myotonic dystrophy type 2 (DM2) is an autosomal dominant progressive disease involving skeletal and cardiac muscle and brain. It is caused by a tetranucleotide repeat within the first intron of the CNBP gene that leads to an alteration of the

Disruption of the ribosomal P complex leads to stress-induced autophagy.

Ana Artero-Castro et al.

Autophagy, 11(9), 1499-1519 (2015-07-16)

The human ribosomal P complex, which consists of the acidic ribosomal P proteins RPLP0, RPLP1, and RPLP2 (RPLP proteins), recruits translational factors, facilitating protein synthesis. Recently, we showed that overexpression of RPLP1 immortalizes primary cells and contributes to transformation. Moreover

Regulation of lipid production by light-emitting diodes in human sebocytes.

Yu Ra Jung et al.

Archives of dermatological research, 307(3), 265-273 (2015-02-19)

Light-emitting diodes (LED) have been used to treat acne vulgaris. However, the efficacy of LED on sebaceous lipid production in vitro has not been examined. This study investigated the efficacy of 415 nm blue light and 630 nm red light

The role of physiological mechanical cues on mesenchymal stem cell differentiation in an airway tract-like dense collagen-silk fibroin construct.

Chiara E Ghezzi et al.

Biomaterials, 35(24), 6236-6247 (2014-05-14)

Airway tracts serve as a conduit of transport in the respiratory system. Architecturally, these are composed of cartilage rings that offer flexibility and prevent collapse during normal breathing. To this end, the successful regeneration of an airway tract requires the

Resveratrol loaded gelatin nanoparticles synergistically inhibits cell cycle progression and constitutive NF-kappaB activation, and induces apoptosis in non-small cell lung cancer cells.

Subburayan Karthikeyan et al.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 70, 274-282 (2015-03-18)

Previously, we reported that the prepared resveratrol (RSV) loaded gelatin nanoparticles (GNPs) possessed enhanced anticancer effect than free RSV in non-small cell lung carcinoma cells and Swiss albino mice. The present study aims to explore the relevant mechanism of cell

A comparative metagenome survey of the fecal microbiota of a breast- and a plant-fed Asian elephant reveals an unexpectedly high diversity of glycoside hydrolase family enzymes.

Nele Ilmberger et al.

PloS one, 9(9), e106707-e106707 (2014-09-11)

A phylogenetic and metagenomic study of elephant feces samples (derived from a three-weeks-old and a six-years-old Asian elephant) was conducted in order to describe the microbiota inhabiting this large land-living animal. The microbial diversity was examined via 16S rRNA gene

Dispersive micro-solid-phase extraction of benzodiazepines from biological fluids based on polyaniline/magnetic nanoparticles composite.

Ali Akbar Asgharinezhad et al.

Analytica chimica acta, 844, 80-89 (2014-08-31)

In this study, diverse types of Fe3O4 nanocomposites modified by polyaniline, polypyrrole, and aniline-pyrrole copolymer were synthesized through chemical oxidative polymerization process for dispersive-μ-solid phase extraction (D-μ-SPE) in the presence of various dopants. The results showed that the nanocomposite modified

The 15-lipoxygenase inhibitory, antioxidant, antimycobacterial activity and cytotoxicity of fourteen ethnomedicinally used African spices and culinary herbs.

Jean Paul Dzoyem et al.

Journal of ethnopharmacology, 156, 1-8 (2014-08-26)

Culinary herbs and spices are widely used ethnomedically across Africa. They are traditionally employed in the treatment of several ailments including inflammation disorders, pain alleviation and infectious diseases. Pharmacological studies are necessary to provide a scientific basis to substantiate their

Gene expression profiling in pachyonychia congenita skin.

Yu-An Cao et al.

Journal of dermatological science, 77(3), 156-165 (2015-02-07)

Pachyonychia congenita (PC) is a skin disorder resulting from mutations in keratin (K) proteins including K6a, K6b, K16, and K17. One of the major symptoms is painful plantar keratoderma. The pathogenic sequelae resulting from the keratin mutations remain unclear. To

Cigarette smoking hinders human periodontal ligament-derived stem cell proliferation, migration and differentiation potentials.

Tsz Kin Ng et al.

Scientific reports, 5, 7828-7828 (2015-01-17)

Cigarette smoking contributes to the development of destructive periodontal diseases and delays its healing process. Our previous study demonstrated that nicotine, a major constituent in the cigarette smoke, inhibits the regenerative potentials of human periodontal ligament-derived stem cells (PDLSC) through

Syntrophic growth of Desulfovibrio alaskensis requires genes for H2 and formate metabolism as well as those for flagellum and biofilm formation.

Lee R Krumholz et al.

Applied and environmental microbiology, 81(7), 2339-2348 (2015-01-27)

In anaerobic environments, mutually beneficial metabolic interactions between microorganisms (syntrophy) are essential for oxidation of organic matter to carbon dioxide and methane. Syntrophic interactions typically involve a microorganism degrading an organic compound to primary fermentation by-products and sources of electrons

Skin sensitization induced Langerhans' cell mobilization: variable requirements for tumour necrosis factor-α.

Laura H Eaton et al.

Immunology, 144(1), 139-148 (2014-07-22)

Upon antigen/allergen recognition, epidermal Langerhans' cells (LC) are mobilized and migrate to the local lymph node where they play a major role in initiating or regulating immune responses. It had been proposed that all chemical allergens induce LC migration via

Evaluation of injection methods for fast, high peak capacity separations with low thermal mass gas chromatography.

Brian D Fitz et al.

Journal of chromatography. A, 1392, 82-90 (2015-03-31)

Low thermal mass gas chromatography (LTM-GC) was evaluated for rapid, high peak capacity separations with three injection methods: liquid, headspace solid phase micro-extraction (HS-SPME), and direct vapor. An Agilent LTM equipped with a short microbore capillary column was operated at

Glucose-coated superparamagnetic iron oxide nanoparticles prepared by metal vapour synthesis are electively internalized in a pancreatic adenocarcinoma cell line expressing GLUT1 transporter.

Daniele Barbaro et al.

PloS one, 10(4), e0123159-e0123159 (2015-04-16)

Iron oxide nanoparticles (IONP) can have a variety of biomedical applications due to their visualization properties through Magnetic Resonance Imaging (MRI) and heating with radio frequency or alternating magnetic fields. In the oncological field, coating IONP with organic compounds to

In vitro safety assessment of food ingredients in canine renal proximal tubule cells.

J Koči et al.

Toxicology in vitro : an international journal published in association with BIBRA, 29(2), 289-298 (2014-12-03)

In vitro models are useful tools to initially assess the toxicological safety hazards of food ingredients. Toxicities of cinnamaldehyde (CINA), cinnamon bark oil, lemongrass oil (LGO), thymol, thyme oil (TO), clove leaf oil, eugenol, ginger root extract (GRE), citric acid

Chemometric assisted ultrasound leaching-solid phase extraction followed by dispersive-solidification liquid-liquid microextraction for determination of organophosphorus pesticides in soil samples.

Kamyar Ahmadi et al.

Talanta, 137, 167-173 (2015-03-17)

Ultrasound leaching-solid phase extraction (USL-SPE) followed by dispersive-solidification liquid-liquid microextraction (DSLLME) was developed for preconcentration and determination of organophosphorus pesticides (OPPs) in soil samples prior gas chromatography-mass spectrometry analysis. At first, OPPs were ultrasonically leached from soil samples by using

Recovery of oxygenated ignitable liquids by zeolites, Part II: Dual-mode heated passive headspace extraction.

Corissa L Rodgers et al.

Forensic science international, 240, 144-150 (2014-05-09)

Previous studies performed by our research group have suggested that zeolites are a suitable adsorbent for the recovery of oxygenates from fire debris through heated passive headspace extraction. Zeolite 13X, in particular, has been shown to be effective for recovering

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