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Showing 31-60 of 6965 results for "721956" within Papers
Mônica Siqueira Ferreira et al.
Analytica chimica acta, 845, 62-69 (2014-09-10)
Schistosomiasis is a common tropical disease caused by Schistosoma species Schistosomiasis' pathogenesis is known to vary according to the worms' strain. Moreover, high parasitical virulence is directly related to eggs release and granulomatous inflammation in the host's organs. This virulence
Qian Xu et al.
Journal of molecular neuroscience : MN, 55(2), 289-296 (2014-05-16)
Cerebral ischemic injury involves a variety of cellular and molecular events. Signal transducers and activators of transcription-1 (STAT-1) activation is associated with neuronal cell death and contributes to ischemic injury. The effects of fludarabine, a specific inhibitor of STAT1 protein
Guoyun Li et al.
Journal of chromatography. A, 1397, 43-51 (2015-04-29)
Pneumococcal type-3 polysaccharide (Pn3P) is considered a major target for the development of a human vaccine to protect against Streptococcus pneumoniae infection. Thus, it is critical to develop methods for the preparation and analysis of Pn3P-derived oligosaccharides to better understand
Helene Thorsen Rønning et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 32(12), 2120-2130 (2015-09-29)
Lichenysin produced by 53 different Bacillus licheniformis strains has been structurally examined with a qualitative liquid chromatography-tandem mass spectrometry (LC-MS/MS) method using quadrupole-time-of-flight mass spectrometry. The same lichenysin isoforms are produced from all strains, indicating that the growth conditions have
Hao Ran Geng et al.
Analytical and bioanalytical chemistry, 407(29), 8803-8812 (2015-09-28)
A new surface molecularly imprinted polymer (MIP) based on nano-TiO2 was developed using propazine (Pro) as a template molecule, ethyleneglycol dimethacrylate (EGDMA) as a crosslinker, methacrylic acid (MAA) as a functional monomer, and 2,2'-azobis (isobutyronitrile) (AIBN) as an initiator. Structures
Sara Triñanes et al.
Talanta, 132, 433-442 (2014-12-06)
A new straightforward and inexpensive sample screening method for both EPA and EU priority polycyclic aromatic hydrocarbons (PAHs) in water has been developed. The method is based on combined direct immersion and headspace (DIHS) sorptive extraction, using low-cost disposable material
Rocio Aranda-Rodriguez et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 992, 76-85 (2015-05-13)
Humans are continuously exposed to volatile organic compounds (VOCs) as these chemicals are ubiquitously present in most indoor and outdoor environments. In order to assess recent exposure to VOCs for population-based studies, VOCs are measured in the blood of participants.
Mariano Sánchez-Siles et al.
International journal of dermatology, 53(12), 1454-1459 (2014-06-06)
A study is made of DNA damage and apoptosis in a group of patients with oral leukoplakia (OL) with mild dysplasia. The study comprised 30 patients with a clinicopathological diagnosis of OL with mild dysplasia and 30 controls. Both samples
Tina Jerman Klen et al.
Journal of agricultural and food chemistry, 63(15), 3859-3872 (2015-03-19)
All of the matrices entailed in olive oil processing were screened for the presence of known and new phenol constituents in a single study, combining an ultra high pressure liquid chromatography system with diode array and electrospray ionization quadrupole time-of-flight
Masahiko Isaka et al.
The Journal of antibiotics, 68(5), 334-338 (2014-11-20)
Two new hydroanthraquinones, paradictyoarthrins A (1) and B (2), were isolated from the mangrove-derived fungus Paradictyoarthrinium diffractum BCC 8704. Structures of the new compounds were elucidated by analyses of the NMR spectroscopic and mass spectrometry data. The absolute configuration of
Andrea Gini et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(34), 12053-12060 (2015-07-28)
N-carbamoyl nitrones represent an important class of reagents for the synthesis of a variety of natural and biologically active compounds. These compounds are generally converted into valuable 4-isoxazolines upon cyclization reaction with dipolarophiles. However, these types of N-protected nitrones are
Yanjuan Tang et al.
Experimental hematology, 43(7), 554-564 (2015-05-02)
The phosphatidylinositol 3-kinase/AKT pathway is an integral component of signaling involved in the development of many cancers, including myeloid leukemias such as chronic myeloid leukemia and acute myeloid leukemia (AML). Increased AKT1 activity is frequently seen in AML patients, providing
Jin Woo Park et al.
Archives of pharmacal research, 37(12), 1560-1569 (2013-11-21)
Risedronate is widely used clinically to treat osteoporosis, Paget's disease, hypercalcemia, bone metastasis, and multiple myeloma. However, its oral efficacy is restricted due to its low bioavailability and severe gastrointestinal adverse effects. This study was designed to evaluate the effect
Olivera Magdenoska et al.
Analytical biochemistry, 487, 17-26 (2015-07-05)
For quantification of intracellular metabolites, mass spectrometry combined with liquid chromatography, capillary electrophoresis, or gas chromatography is currently the method of choice, especially when combined with stable isotope-labeled internal standards (SIL-ISs). Due to the difficulties in finding a biological matrix
Haoyue Zhang et al.
Molecular genetics and metabolism, 114(2), 123-128 (2014-12-03)
Mucopolysaccharidoses (MPS) are complex storage disorders that result in the accumulation of glycosaminoglycans (GAGs) in urine, blood, brain and other tissues. Symptomatic patients are typically screened for MPS by analysis of GAG in urine. Current screening methods used in clinical
Xiaoyong Yuan et al.
ACS nano, 9(2), 1749-1758 (2015-01-15)
Presently, eye injuries are treated by topical eye drop therapy. Because of the ocular surface barriers, topical eye drops must be applied several times in a day, causing side effects such as glaucoma, cataract, and poor patient compliance. This article
Momei Zhou et al.
Journal of virology, 89(17), 8999-9009 (2015-06-19)
Interaction between gH/gL and the fusion protein gB is likely a conserved feature of the entry mechanism for all herpesviruses. Human cytomegalovirus (HCMV) gH/gL can be bound by gO or by the set of proteins UL128, UL130, and UL131, forming
Isabel Sospedra et al.
Journal of food science, 80(6), H1425-H1431 (2015-05-16)
Obesity prevalence in developed countries has promoted the need to identify the mechanisms involved in control of feeding and energy balance. We have tested the hypothesis that different fats present in diet composition may contribute in body weight gain and
Martin Korn et al.
PloS one, 10(5), e0125960-e0125960 (2015-05-21)
We used insertional mutagenesis by Agrobacterium tumefaciens mediated transformation (ATMT) to isolate pathogenicity mutants of Colletotrichum higginsianum. From a collection of 7200 insertion mutants we isolated 75 mutants with reduced symptoms. 19 of these were affected in host penetration, while
Zoe M Smith et al.
Talanta, 130, 221-225 (2014-08-28)
Previous applications of manganese(IV) as a chemiluminescence reagent have required the use of formaldehyde to enhance the emission intensity to analytically useful levels. However, this known human carcinogen (by inhalation) is not ideal for routine application. A wide range of
Mette Thing et al.
Journal of pharmaceutical sciences, 103(12), 4021-4029 (2014-10-31)
Long-acting nonsteroidal anti-inflammatory drug formulations for intra-articular injection might be effective in the management of joint pain and inflammation associated sports injuries and osteoarthritis. In this study, a prodrug-based delivery system was evaluated. The synthesized diclofenac ester prodrug, a weak
Li Ren et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 959, 16-21 (2014-04-22)
A liquid chromatography-electrospray ionization tandem mass spectrometry method was established and validated for the determination of bevantolol in human plasma using propranolol as the internal standard. The optimal chromatographic behavior of bevantolol and propranolol was achieved on a Welch Ultimate
Wei Wei et al.
Molecular plant, 8(9), 1412-1424 (2015-06-03)
Ginsenosides, the main pharmacologically active natural compounds in ginseng (Panax ginseng), are mostly the glycosylated products of protopanaxadiol (PPD) and protopanaxatriol (PPT). No uridine diphosphate glycosyltransferase (UGT), which catalyzes PPT to produce PPT-type ginsenosides, has yet been reported. Here, we
A M de Lucas Cerrillo et al.
Gene therapy, 22(5), 365-373 (2015-02-27)
Erythropoietin (EPO) is critical for red blood cell production and is also an effective neuroprotective agent. However, it may contribute to pathological angiogenesis. Here we investigate the angiogenic potential of EPO and a mutant form with attenuated erythropoietic activity, EPO-R76E
Elisabeth Eckert et al.
Journal of chromatography. A, 1410, 173-180 (2015-08-06)
Di(2-ethylhexyl) phthalate (DEHP) and tri(2-ethylhexyl) trimellitate (TEHTM or TOTM) are common plasticizers that are also largely used for PVC medical devices, e.g. bags and tubing for blood transfusions and infusions. The leachability of medical devices is a well-known situation of
Margaret Simons et al.
Plant physiology, 166(3), 1659-1674 (2014-09-25)
Maize (Zea mays) is an important C4 plant due to its widespread use as a cereal and energy crop. A second-generation genome-scale metabolic model for the maize leaf was created to capture C4 carbon fixation and investigate nitrogen (N) assimilation
Zulin Zhang et al.
Journal of separation science, 37(24), 3699-3705 (2014-10-02)
A simple and rapid method was developed for the simultaneous analysis of nine different pesticides in water samples by gas chromatography with mass spectrometry. A number of parameters that may affect the recovery of pesticides, such as the type of
Mei-ling Zhang et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 36(5), 3521-3531 (2015-01-01)
Homeobox genes, a superfamily of evolutionarily conserved developmental genes, function as critical master regulatory factors in controlling body plan specification and cell fate determination. Recently, a substantial body of evidence indicates that the aberrant Homeobox (HOX) genes also play key
Coleman T Turgeon et al.
Molecular genetics and metabolism, 114(1), 46-50 (2014-12-08)
Pre-symptomatic hematopoietic stem cell transplantation is essential to achieve best possible outcomes for patients with the childhood cerebral form of X-linked adrenoleukodystrophy (X-ALD). We describe a high-throughput method for measurement of C20-C26 lysophosphatidylcholines (LPCs) and biochemical diagnosis of X-ALD using
Yisheng Chen et al.
Journal of chromatography. A, 1356, 249-257 (2014-07-13)
The world-wide usage and partly abuse of veterinary antibiotics resulted in a pressing need to control residues in animal-derived foods. Large-scale screening for residues of antibiotics is typically performed by microbial agar diffusion tests. This work employing high-performance thin-layer chromatography
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