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Showing 31-60 of 6965 results for "721956" within Papers
Maryam Rajabi et al.
Journal of separation science, 38(14), 2496-2502 (2015-05-20)
In this work, two disperser-free microextraction methods, namely, air-agitated liquid-liquid microextraction and ultrasound-assisted emulsification microextraction are compared for the determination of a number of polycyclic aromatic hydrocarbons in aqueous samples, followed by gas chromatography with flame ionization detection. The effects
Christina Wu et al.
Circulation. Heart failure, 8(6), 1077-1087 (2015-08-14)
Skeletal muscle dysfunction and exercise intolerance are clinical hallmarks of patients with heart failure. These have been linked to a progressive catabolic state, skeletal muscle inflammation, and impaired oxidative metabolism. Previous studies suggest beneficial effects of ω-3 polyunsaturated fatty acids
Keisuke Ohsumi et al.
The Journal of antibiotics, 67(10), 707-711 (2014-05-29)
A novel antifungal agent, AS2077715, was isolated from the fermentation broth of a fungal strain (339855) identified as a new Capnodium species based on morphological characteristics and large-subunit ribosomal DNA sequencing. AS2077715 was isolated as a white powder via solvent
Trayambak Basak et al.
Journal of proteomics, 127(Pt A), 169-177 (2015-03-21)
Coronary artery disease (CAD), a complex metabolic disorder, is one of the largest causes of death worldwide. Both environmental and genetic factors contribute to the etiology of this metabolic disease. The gene-environment interaction could lead to modulation of various metabolic
Salim Sioud et al.
Rapid communications in mass spectrometry : RCM, 28(22), 2389-2397 (2014-10-11)
The formation of ions during atmospheric pressure photoionization (APPI) mass spectrometry in the positive mode usually provides radical cations and/or protonated species. Intriguingly, during the analysis of some N-alkyl-substituted thieno[3,4-c]pyrrole-4,6-dione (TPD) derivatives synthesized in our laboratory, unusual [M-H](+) ion peaks
Marco Pistolozzi et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(3), 344-352 (2014-12-17)
This work describes the sequential hydrolysis of bambuterol enantiomers and their monocarbamate metabolites (MONO) catalyzed by human butyrylcholinesterase (BChE) as well as the enzyme inhibition resulting from this process. Particular emphasis is given to the contribution given by MONO to
Laine R Compton et al.
Rapid communications in mass spectrometry : RCM, 29(1), 67-73 (2014-12-03)
We introduce remote laser ablation electrospray ionization (LAESI), a novel, non-proximate ambient sampling technique. Remote LAESI allows additional analytical instrumentation to be incorporated during sample analysis. This work demonstrates the utility of remote LAESI and, when combined with optical microscopy
Enikő Lázár et al.
Free radical biology & medicine, 83, 273-282 (2015-02-25)
Basement membranes provide structural support and convey regulatory signals to cells in diverse tissues. Assembly of collagen IV into a sheet-like network is a fundamental mechanism during the formation of basement membranes. Peroxidasin (PXDN) was recently described to catalyze crosslinking
Wei Li et al.
Die Pharmazie, 70(5), 340-346 (2015-06-13)
In the present work, we report efficient production of ginsenoside M1 (G-M1) from ginsenoside Rd (G-Rd) by snailase hydrolysis using response surface methodology (RSM). During investigation of the hydrolysis of ginsenoside Rd by various glycoside hydrolases, snailase showed a strong
Yoshifumi Nishikawa et al.
PloS one, 10(8), e0135701-e0135701 (2015-08-15)
Lysophospholipids are important signaling molecules in animals and metazoan cells. They are widely distributed among marine invertebrates, where their physiological roles are unknown. Sea cucumbers produce unique lysophospholipids. In this study, two lysophospholipids were detected in Holothuria atra for the
Teresa L Parsons et al.
Antimicrobial agents and chemotherapy, 58(11), 6747-6757 (2014-09-04)
The quantification of antituberculosis drug concentrations in multinational trials currently requires the collection of modest blood volumes, centrifugation, aliquoting of plasma, freezing, and keeping samples frozen during shipping. We prospectively enrolled healthy individuals into the Tuberculosis Trials Consortium Study 29B
Michael Zuykov et al.
Journal of invertebrate pathology, 120, 23-32 (2014-05-20)
During autumn 2012 and spring 2013, blue mussels Mytilus edulis (L.) with strongly deformed (L-shaped) posterior shell margins and green spots in soft tissue (microalgae) were collected from intertidal zone along the south shore of the Lower St. Lawrence Estuary
Brian J Worfolk et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(46), 14138-14143 (2015-10-31)
With consumer electronics transitioning toward flexible products, there is a growing need for high-performance, mechanically robust, and inexpensive transparent conductors (TCs) for optoelectronic device integration. Herein, we report the scalable fabrication of highly conductive poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) ( PSS) thin films via
Naotaro Akiyama et al.
The Laryngoscope, 124(10), 2404-2410 (2014-06-12)
High negative pressure in the middle ear was thought to be closely related to the etiology of retraction-type cholesteatoma. Recently, it has been detected that mechanical forces are important factors in epithelial turnover and affect cytoskeletal remodeling. Continuous negative pressure
Phurpa Wangchuk et al.
Scientific reports, 5, 12845-12845 (2015-08-05)
Aconitum laciniatum is used in Bhutanese traditional medicine for treating various chronic infections and inflammatory conditions. We carried out in-depth isolation and characterization of the phytochemicals from the root component and determined the anti-inflammatory effects of the isolated compounds against
Cong-Mei Cao et al.
Journal of chromatographic science, 53(7), 1044-1047 (2014-12-04)
An analytical method based on high-performance liquid chromatography-photodiode array detection was developed for the simultaneous determination of three anti-proliferative withanolides [withalongolide A ( 1: ), withaferin A ( 2: ) and withalongolide B ( 3: )] present in the aboveground
Hao Zhang et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 32(7), 1083-1088 (2015-05-09)
This study investigated the effect of different types of commercial oils (rice bran oil, shortening oil, high-oleic rapeseed oil, low-erucic acid rapeseed oil, blend oil A and blend oil B) and frying cycles on acrylamide formation during the preparation of
Rouhollah Khodadust et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 68(8), 979-987 (2014-12-03)
The objective of this study was to develop and evaluate the anticancer activity and the safety of a combinational drug delivery system using polyamidoamine (PAMAM) dendrimer-coated iron oxide nanoparticles for doxorubicin and poly I:C delivery in vitro. Dendrimer-coated magnetic nanoparticles
Nikolaos Lemonakis et al.
Talanta, 147, 402-409 (2015-11-26)
A multistage optimization of all the parameters affecting detection/response in an LTQ-orbitrap analyzer was performed, using a design of experiments methodology. The signal intensity, a critical issue for mass analysis, was investigated and the optimization process was completed in three
John Warner et al.
Talanta, 146, 279-284 (2015-12-24)
Solvent tolerance of immobilized enzymes is important for many biosensing and biotechnological applications. In this paper we report an acetylcholinesterase (AChE) biosensor based on chitosan that exhibits high solvent resistance and enables sensitive detection of pesticides in presence of a
Karen E Parrish et al.
Molecular cancer therapeutics, 14(12), 2735-2743 (2015-10-07)
PARP inhibition can enhance the efficacy of temozolomide and prolong survival in orthotopic glioblastoma (GBM) xenografts. The aim of this study was to evaluate the combination of the PARP inhibitor rucaparib with temozolomide and to correlate pharmacokinetic and pharmacodynamic studies
Chang-Han Chen et al.
Molecular cancer, 14, 83-83 (2015-04-19)
Head and neck cancer (HNC) is a highly invasive cancer. Aurora-A has been reported for a number of malignancies. However, the identity of downstream effectors responsible for its aggressive phenotype in HNC remains underinvestigated. The mRNA and protein expression levels
Elena Geromichalou et al.
European journal of medicinal chemistry, 96, 47-57 (2015-04-16)
Recent science evidenced the interlinkage of oxidative stress and cancer. Due to the inherent complexity of cancer and its accompanying effect of oxidative stress, novel molecules, containing combinatorial functionalities should be targeted. Herein, we synthesized gemcitabine-5'-O-lipoate derived from a regioselective
Verena Pfirrmann et al.
Cytotherapy, 17(8), 1139-1151 (2015-06-15)
Human cytomegalovirus (CMV) infection and reactivation is a leading complication of allogeneic hematopoietic stem cell transplantation (HSCT). In addition to drug treatment, the adoptive transfer of virus-specific T cells to restore cellular immunity has become a standard therapy after allogeneic
F Matsuda et al.
Journal of neuroendocrinology, 27(1), 57-65 (2014-11-05)
A luteinising hormone (LH) surge is fundamental to the induction of ovulation in mammalian females. The administration of a preovulatory level of oestrogen evokes an LH surge in ovariectomised females, whereas the response to oestrogen in castrated males differs among
Ting Liu et al.
Oncotarget, 6(10), 7992-8006 (2015-03-24)
All-trans retinoic acid (ATRA) is a differentiating agent for the treatment of acute promyelocytic leukemia (APL). However, the therapeutic efficacy of ATRA has limitations. Tetrandrine is a traditional Chinese medicinal herb extract with antitumor effects. In this study, we investigated
Malgorzata Knet et al.
Theriogenology, 84(6), 927-939 (2015-07-05)
Recent studies suggest that disturbing androgen-signaling pathways in porcine ovarian follicles may cause granulosa cell (GC) death. For this reason, we investigated which apoptotic pathway is initiated after GC exposure to an environmental antiandrogen, vinclozolin (Vnz), in vitro. Immunocytochemistry, Western
Albert Ruhí et al.
The Science of the total environment, 540, 250-259 (2015-07-15)
Increasing evidence exists that emerging pollutants such as pharmaceuticals (PhACs) and endocrine-disrupting compounds (EDCs) can be bioaccumulated by aquatic organisms. However, the relative role of trophic transfers in the acquisition of emerging pollutants by aquatic organisms remains largely unexplored. In
Niketkumar Patel et al.
Pharmaceutical development and technology, 20(4), 442-457 (2014-01-29)
Freshly excised rat skin and side-by-side permeation cells were used to study the effect of electronic and formulation variables on transdermal iontophoretic delivery of tacrine. Current strength at 0.1-0.3 mA was observed to be the driving force resulting in tacrine
Luca Campone et al.
Analytical and bioanalytical chemistry, 407(10), 2899-2911 (2015-02-20)
According to current demands and future perspectives in food safety, this study reports a fast and fully automated analytical method for the simultaneous analysis of the mycotoxins with high toxicity and wide spread, aflatoxins (AFs) and ochratoxin A (OTA) in
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