CN
Search Within
A4669
Applied Filters:
Keyword:'A4669'
Showing 1-30 of 146 results for "A4669" within Papers
Nicky Perkins et al.
Sexually transmitted infections, 87(4), 292-295 (2011-03-17)
Infection with herpes simplex virus (HSV) is extremely common worldwide. In immunocompromised patients anogenital HSV disease may have atypical features and may be very severe. Treatment of aciclovir-resistant anogenital HSV disease is challenging, as resistance to alternative treatments may occur
Clinical problem-solving. A creeping suspicion.
Casey M Rice et al.
The New England journal of medicine, 371(1), 68-73 (2014-07-06)
Uncertainties around antivirals in severe Bell's palsy trial.
Ricky D Turgeon et al.
The American journal of medicine, 126(12), e31-e31 (2013-11-23)
Paul J Park et al.
Investigative ophthalmology & visual science, 54(9), 6373-6381 (2013-08-31)
To investigate the efficacy of a combination treatment composed of the cationic, membrane-penetrating peptide G2, and acyclovir (ACV) in both in vitro and ex vivo models of herpes simplex virus 1 (HSV-1) ocular infection. The antiviral activity of a combined
Mark T Bokhart et al.
Analytical and bioanalytical chemistry, 407(8), 2073-2084 (2014-10-17)
A quantitative mass spectrometry imaging (QMSI) technique using infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) is demonstrated for the antiretroviral (ARV) drug emtricitabine in incubated human cervical tissue. Method development of the QMSI technique leads to a gain in sensitivity
Murilo L Bello et al.
PloS one, 10(3), e0121110-e0121110 (2015-03-25)
Layered drug delivery carriers are current targets of nanotechnology studies since they are able to accommodate pharmacologically active substances and are effective at modulating drug release. Sodium montmorillonite (Na-MMT) is a clay that has suitable properties for developing new pharmaceutical
Secondary viral encephalitis in a patient with pyogenic liver abscess.
N Sahni et al.
Anaesthesia and intensive care, 42(4), 528-530 (2014-06-27)
Martina Prelog et al.
Pediatric nephrology (Berlin, Germany), 26(5), 663-673 (2010-11-16)
Clear recommendations for the management of acute varicella-zoster virus (VZV) infections for cases of significant exposure and the use of prophylactic drugs after solid-organ transplantation are missing due to the lack of evidence by prospective studies. Heterogeneity in patient groups
Shar-yin N Huang et al.
Nucleic acids research, 41(16), 7793-7803 (2013-06-19)
Chain-terminating nucleoside analogs (CTNAs) that cause stalling or premature termination of DNA replication forks are widely used as anticancer and antiviral drugs. However, it is not well understood how cells repair the DNA damage induced by these drugs. Here, we
Darren Svirskis et al.
Pharmaceutical development and technology, 19(5), 571-576 (2013-07-19)
This study aimed at improving the oral bioavailability of acyclovir (ACV) through incorporating it into gastroretentive dosage form based on floating hollow chitosan beads. Hollow chitosan beads were prepared using a solvent free, ionotropic gelation method. The effect of formulation
Response.
Sam Eljamel
Journal of neurosurgery, 118(6), 1386-1386 (2013-07-23)
Should all adults with varicella be prescribed antiviral treatment?
D Ashley R Watson
The Medical journal of Australia, 198(5), 259-259 (2013-03-19)
Sonia Burrel et al.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 58(1), 321-324 (2013-06-05)
Herpes simplex virus type 1 (HSV-1) is a leading cause of corneal blindness. Acyclovir (ACV) constitutes the standard treatment of HSV infections including herpetic keratitis (HK). HSV resistance to ACV is mainly described in immunocompromised patients. We describe two cases
J Sipe et al.
The Cochrane database of systematic reviews, (2)(2), CD001869-CD001869 (2001-06-19)
The most common disorder of the facial nerve is acute idiopathic facial paralysis or Bell's palsy and there may be significant morbidity or incomplete recovery associated with severe cases. Although the cause remains unknown, recent evidence suggests a possible association
L Z Rubsam et al.
Cancer research, 58(17), 3873-3882 (1998-09-10)
Enzyme-prodrug therapy using ganciclovir and herpes simplex virus-thymidine kinase (HSV-TK) has demonstrated excellent antitumor activity in many different types of malignant cells. Previously, we noted that ganciclovir was substantially more cytotoxic than other HSV-TK substrates. Therefore, we embarked on a
Pierre-André Billat et al.
Analytical and bioanalytical chemistry, 407(12), 3449-3456 (2015-02-24)
Ganciclovir (GCV) is prescribed for cytomegalovirus infection which is a major issue in immunodepressed patients. It is however characterized by hematological toxicity. A better understanding of GCV concentration-effects relationships implies the measurement of intracellular forms. The objective of this study
T P Klassen et al.
The Cochrane database of systematic reviews, (2)(2), CD002980-CD002980 (2004-04-24)
Acyclovir has the potential to shorten the course of illness which may result in reduced costs and morbidity associated with chickenpox. 1) To examine the evidence evaluating the efficacy of acyclovir in alleviating symptoms of chickenpox and shortening the duration
Eric T Stoopler et al.
Journal of the California Dental Association, 41(4), 259-262 (2013-05-28)
Oral and perioral herpes simplex virus (HSV) infections in healthy individuals often present with signs and symptoms that are clearly recognized by oral health care providers (OHCPs). Management of these infections is dependent upon a variety of factors and several
Aaron A R Tobian et al.
The Journal of infectious diseases, 208(5), 839-846 (2013-07-03)
The association between initiation of antiretroviral therapy (ART) for human immunodeficiency virus (HIV) infection and possible herpes simplex virus type 2 (HSV-2) shedding and genital ulcer disease (GUD) has not been evaluated. GUD and vaginal HSV-2 shedding were evaluated among
J Sipe et al.
The Cochrane database of systematic reviews, (4)(4), CD001869-CD001869 (2001-11-01)
The most common disorder of the facial nerve is acute idiopathic facial paralysis or Bell's palsy and there may be significant morbidity or incomplete recovery associated with severe cases. Although the cause remains unknown, recent evidence suggests a possible association
Monique van Velzen et al.
The Journal of infectious diseases, 208(9), 1359-1365 (2013-08-01)
Long-term acyclovir (ACV) prophylaxis, recommended to prevent recurrent herpes simplex virus type 1 (HSV-1) ocular disorders, may pose a risk for ACV-refractory disease due to ACV resistance. We determined the effect of ACV prophylaxis on the prevalence of corneal ACV-resistant
Suqin Wu et al.
Journal of chromatography. A, 1285, 124-131 (2013-03-16)
This paper demonstrates a novel approach to assembling homogeneous molecularly imprinted polymers (MIPs) based on mimicking multiple hydrogen bonds between nucleotide bases by preparing acyclovir (ACV) as a template and using coatings grafted on silica supports. (1)H NMR studies confirmed
María Luisa Mateos-Martín et al.
Analytical and bioanalytical chemistry, 406(22), 5501-5506 (2014-06-28)
Chamaecrista nictitans (L) extract possesses antiviral properties; it acts against the herpes simplex virus, and this may be attributed to its constituent phenolics. Here, high-resolution LC-ESI-MS/MS is used to identify the phenolic components of the most potent fraction of the
Prescrire international, 20(119), 205-207 (2011-10-01)
Management of episodes of herpes labialis (cold sores) in otherwise healthy individuals is mainly based on hygiene measures intended to avoid transmitting the virus. At best, topical treatment with aciclovir, an antiviral drug, simply reduces the duration of the episode.
B P Shelley et al.
Journal of the neurological sciences, 252(2), 177-180 (2006-12-22)
This is a case report of PCR proven herpes simplex (HSV-1) encephalitis in a 26 years old immunocompetent adult taking an unusual course of acute intracerebral haematoma after successful and complete recovery with acyclovir therapy. This transient late complication was
Dinah Gould
Nursing standard (Royal College of Nursing (Great Britain) : 1987), 28(33), 52-58 (2014-04-17)
The varicella zoster virus causes two infections: varicella, also known as chickenpox occurring mostly in childhood, and herpes zoster, also known as shingles affecting mainly older people. Varicella usually occurs in children under ten years of age. It is generally
Laurence Le Cleach et al.
The Cochrane database of systematic reviews, 8(8), CD009036-CD009036 (2014-08-05)
Genital herpes is caused by herpes simplex virus 1 (HSV-1) or 2 (HSV-2). Some infected people experience outbreaks of genital herpes, typically, characterized by vesicular and erosive localized painful genital lesions. To compare the effectiveness and safety of three oral
Adalbert Krawczyk et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(17), 6760-6765 (2013-04-10)
Despite the availability of antiviral chemotherapy, herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) infections remain a severe global health problem. Of particular concern is the growing incidence of drug resistance in immunocompromised patients, which stresses the urgency
Roberto H Caraballo et al.
Seizure, 22(7), 553-559 (2013-05-07)
To analyze the electroclinical features, neuroimaging findings, treatment, and outcome of 12 patients with febrile infection-related epilepsy syndrome (FIRES). This is a retrospective study of 12 children with FIRES with a mean time of follow-up of 6.5 years carried out
André Engesland et al.
Journal of pharmaceutical sciences, 104(3), 1119-1127 (2015-01-06)
Cost-effective and efficient methods for permeability screening are crucial during early development of drugs, drug formulations, and cosmeceuticals. Alternatives to animal experiments are impelled for both economical and ethical reasons. The aim of this study was to determine the ability
Page 1 of 5