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Showing 1-30 of 147 results for "A4669" within Papers
Alaa A Salem et al.
Journal of AOAC International, 95(6), 1644-1651 (2013-03-05)
Rapid, simple, and selective methods for determining amantadine HCI and acyclovir antiviral drugs in pharmaceutical and plasma samples were developed using 1H-NMR spectroscopy with dimethyl sulfoxide (DMSO-d6) as the solvent. Integrations of the 1H-NMR signals at 2.07 and 7.82 ppm
Christophe Vanpouille et al.
Current opinion in infectious diseases, 22(6), 583-587 (2009-09-04)
Epidemiological studies have demonstrated that HIV-1 and herpes simplex virus-2 (HSV-2) are responsible for two epidemics and that, by overlapping in risk populations, they reinforce the spreading of both HIV-1 disease and genital herpes. Randomized controlled trials have investigated whether
A 4-day-old neonate with a widespread vesicular rash.
Barry Ladizinski et al.
JAMA, 310(9), 971-972 (2013-09-05)
Don't let herpes melt your brain!
Paul Jhun et al.
Annals of emergency medicine, 64(6), 589-590 (2014-12-03)
Monica M Sauter et al.
Antiviral research, 109, 83-96 (2014-07-06)
Herpes simplex virus type 1 (HSV-1) is an important human pathogen which requires activation of nuclear factor-kappa B (NFκB) during its replication cycle. The persistent nature of HSV-1 infection, and the emergence of drug-resistant strains, highlights the importance of research
Gloria Komazin-Meredith et al.
Antiviral research, 119, 23-27 (2015-04-11)
Monohydroxymethyl methylenecyclopropane nucleosides (MCPNs) with ether or thioether substituents at the 6-position show promise as broad-spectrum herpes virus inhibitors. Their proposed mechanism of action involves sequential phosphorylation to a triphosphate, which can then inhibit viral DNA polymerase. The inhibition of
X W Tong et al.
Anticancer research, 18(2A), 713-718 (1998-06-06)
Adenovirus(ADV) mediated thymidine kinase(TK) gene therapy followed by ganciclovir(GCV) administration is widely used in different types of cancer. ACV shares the same mechanism of selective cell killing in ADV/TK positive cells as GCV and can be used at 4.5 times
Tao Xiong et al.
Journal of nanoscience and nanotechnology, 13(1), 123-128 (2013-05-08)
HSV-tk/ACV induced and killed human adenoid cystic carcinoma cell (ACC-M) in vivo and in vitro, which were observed through optical imaging and green fluorescence protein (GFP) tagging technique. ACC-M was transfected with TK-GFP, and the single clone cell ACC-M-TK-GFP was
Christopher M Hull et al.
Postgraduate medicine, 122(5), 1-6 (2010-09-30)
Recurrent herpes simplex labialis (HSL), also known as orofacial herpes or cold sores, is a common clinical presentation of herpes simplex virus (HSV) infection. It may manifest as painful, distressing, and cosmetically displeasing vesicles on the lips, nose, and nasal
Axel Schubert et al.
Antiviral research, 107, 16-22 (2014-04-22)
The role of mutations in the thymidine kinase (TK, UL23) and DNA polymerase (pol, UL30) genes of herpes simplex virus (HSV) for development of different resistance phenotypes has to be exactly determined before genotypic resistance testing can be implemented in
Aciclovir and its l-valyl ester, valaciclovir.
M L Smiley et al.
Current problems in dermatology, 24, 209-218 (1996-01-01)
Howell-Jolly body-like inclusions in immunocompromised patients with antiviral treatment.
Cristian Morales-Indiano et al.
Annals of hematology, 93(12), 2091-2092 (2014-05-23)
Towards evidence based medicine for paediatricians. Does oral aciclovir improve clinical outcome in immunocompetent children with primary herpes simplex gingivostomatitis?
B Hudson et al.
Archives of disease in childhood, 94(2), 165-167 (2009-01-23)
M Cirri et al.
International journal of pharmaceutics, 490(1-2), 351-359 (2015-06-04)
The aim of this work was to develop a topical formulation with improved permeation properties of acyclovir. Ursodeoxycholic (UDC) and dehydrocholic (DHC) acids were tested as potential enhancers, alone or in combination with different aminoacids. Equimolar binary and ternary systems
Combination therapy for Bell's palsy.
J A de Ru et al.
The American journal of medicine, 126(12), e27-e27 (2013-11-23)
Fanghui Ren et al.
The EMBO journal, 42(19), e113118-e113118 (2023-08-30)
Neurotropic viruses, including herpes simplex virus (HSV) types 1 and 2, have the capacity to infect neurons and can cause severe diseases. This is associated with neuronal cell death, which may contribute to morbidity or even mortality if the infection
María A Vissani et al.
Revista Argentina de microbiologia, 50(4), 380-390 (2018-05-22)
Equid alphaherpesvirus 3 (EHV3) is the etiological agent of equine coital exanthema (ECE), which is a venereal, highly contagious disease, characterized by the formation of papules, vesicles, pustules and ulcers on the external genitalia of mares and stallions. EHV3 remains
J Gueudry et al.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 58(1), 318-320 (2013-06-13)
Varicella-zoster virus (VZV) resistance to acyclovir (ACV) has only been reported in rare cases of immunocompromised patients. We report the first case of an immunocompetent patient with ACV-resistant VZV keratitis associated with a nucleotide deletion in the VZV thymidine kinase
S Leflore et al.
Drug safety, 23(2), 131-142 (2000-08-17)
The objective of this article is to review and evaluate risks and benefits associated with the use of acyclovir in the treatment and prophylaxis of common manifestations of herpes simplex virus (HSV) infections in immunocompetent and immunocompromised patients. Information was
Imir G Metushi et al.
PloS one, 10(5), e0124878-e0124878 (2015-05-30)
Immune mediated adverse drug reactions (IM-ADRs) remain a significant source of patient morbidity that have more recently been shown to be associated with specific class I and/or II human leukocyte antigen (HLA) alleles. Abacavir-induced hypersensitivity syndrome is a CD8+ T
A patient with progressive dyspnea and multiple foci of airspace consolidation.
Keith E Boundy et al.
Chest, 145(1), 167-172 (2014-01-08)
Hasan Hüseyin Doğan et al.
International journal of medicinal mushrooms, 20(3), 201-212 (2018-05-03)
Despite considerable recent work to reveal different features of mushrooms species, the few studies of antiviral activities are inadequate and therefore further studies are required. Morchella conica, M. esculenta, Terfezia boudieri, Pleurotus ostreatus, Tricholoma anatolicum, Fomes fomentarius, Laetiporus sulphureus, Phellinus
Qiaojuan Zhang et al.
Journal of virology, 94(3) (2019-11-07)
The molecular mechanisms of pain associated with alphaherpesvirus latency are not clear. We hypothesize that the voltage-gated sodium channels (VGSC) on the dorsal root ganglion (DRG) neurons controlling electrical impulses may have abnormal activity during latent viral infection and reactivation.
Herpes simplex virus lymphadenitis.
Diego Villa et al.
Blood, 123(1), 12-12 (2014-02-15)
Todd Hatchette et al.
The Pediatric infectious disease journal, 27(1), 75-77 (2007-12-29)
The authors describe an acyclovir-resistant varicella zoster virus infection in a pediatric patient after hematopoietic stem cell transplant, the use of foscarnet as salvage therapy, and review the literature to clarify the pediatric experience with foscarnet in this setting. A
Daniel S Owers et al.
The Cochrane database of systematic reviews, 2(2), CD005133-CD005133 (2013-03-02)
Cytomegalovirus (CMV) is a significant cause of morbidity and mortality in solid organ transplant recipients. Pre-emptive treatment of patients with CMV viraemia using antiviral agents has been suggested as an alternative to routine prophylaxis to prevent CMV disease. This is
Stephanie C Gordts et al.
PloS one, 10(7), e0131219-e0131219 (2015-07-02)
Lignosulfonic acid (LA), a low-cost lignin-derived polyanionic macromolecule, was extensively studied for its anti-HIV and anti-HSV activity in various cellular assays, its mechanism of viral inhibition and safety profile as potential microbicide. LA demonstrated potent inhibitory activity of HIV replication
Haniza Hassan et al.
Nanomaterials (Basel, Switzerland), 10(9) (2020-09-13)
Acyclovir is an antiviral drug used for the treatment of herpes simplex virus infection. Its oral bioavailability is low; therefore, frequent and high doses are prescribed for optimum therapeutic efficacy. Moreover, the current therapeutic regimen of acyclovir is associated with
Keat Choong et al.
Clinical & experimental ophthalmology, 38(3), 309-313 (2010-05-08)
Herpes simplex virus (HSV) keratitis is a common cause of ocular morbidity. Resistance to aciclovir is probably under recognized. We describe three cases of aciclovir-resistant herpes simplex virus keratitis treated with systemic foscarnet and present a review of the pharmacological
Andrew Rowland et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(1), 147-153 (2014-11-09)
This study characterized the kinetics, variability, and factors that affect UDP-glucuronic acid (UDP-GlcUA) uptake by human liver microsomes (HLM). Biphasic kinetics were observed for UDP-GlcUA uptake by HLM. Uptake affinities (assessed as Kd) of the high- and low-affinity components differed
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