Reaction design and optimization

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Phosgene is 170 times more reactive than TP, the main phosgene substitute. Therefore, reactions with phosgene can be carried out under much milder conditions than with TP. Compounds will react faster and at lower temperatures (often at -78°C), preserving sensitive

Red-Al® Reducing Agent

Red-Al®, or sodium bis(2-methoxyethoxy)aluminum dihydride (Vitride®, SMEAH), is a versatile reducing agent and a good substitute for LiAlH4 in many reactions. Red-Al® is nonpyrophoric, although still moisture-sensitive, and is available in solution, allowing for easier handling compared to LiAlH4.

Bis(2-methoxyethyl)aminosulfur Trifluoride (Deoxo-Fluor®)

This technical article discusses Bis(2-methoxyethyl)aminosulfur Trifluoride (Deoxo-Fluor®).

Task-Specific Ionic Liquids

Task-Specific Ionic Liquids (TSILs) for the selective liquid/liquid extraction of heavy metals from aqueous systems were first published by Robin D. Rogers et al. in the year 2001.

BASIONICS™, BASF’s Portfolio of Ionic Liquids

Under the trade name BASIONICS™, BASF offers a portfolio of Ionic Liquids—mainly based on imidazolium cations. The BASIONICS™ portfolio opens up a broad range of basic properties of Ionic Liquids and is classified into standard, acidic, basic, liquid at RT

Chiral Vicinal Diamines for Asymmetric Synthesis

Chiral vicinal diamines are of tremendous interest to the synthetic chemist as they are found in many chiral catalysts and pharmaceuticals.

Selective 1,2-Additions with LaCl3·2LiCl

While the 1,2-addition of Grignard reagents to ketones is undoubtedly a powerful transformation, oftentimes selectivity issues arising from competitive alpha-deprotonation detract from the use of these reagents.

Asymmetric Transfer Hydrogenation

The use of transfer hydrogenation to reduce alkenes, carboxyl groups, ketones, or imines has become very popular.

Oxidizing and Reducing Agents

Oxidation and reduction reactions are some of the most common transformations encountered in organic synthesis

Mild Mg – Halogen Exchange

Substantial progress has been made in magnesium–halogen exchange reactions used for the preparation of functionalized Grignard reagents containing sensitive moieties such as ester or cyano groups.

Heterocyclic Aryne Precursors:
New Opportunities for the Synthesis of
Highly Substituted Indoles and Pyridines

New and efficient methods for the synthesis of functionalized heterocycles are highly sought after.

Alkali Metal Silica Gels from SiGNa

SiGNa Chemistry has recently developed a technology for encapsulating alkali metals into nano-structured porous oxides to create stable, free flowing powders with varying reactivities (based on the intended application).

Applications for Bis(pyridine)iodonium Tetrafluoroborate

Bis(pyridine)iodonium tetrafluoroborate is a mild iodinating and oxidizing reagent capable of selectively reacting with a wide range of unsaturated substrates and tolerates a variety of functional groups.

CBILS©

The use of CBILS© – Carbonate Based Ionic Liquid Synthesis – developed by the Austrian company proionic, offers one of the simplest, yet most elegant synthetic methods for the production of ionic liquids

Trialkylphosphine for Morita-Baylis Hillman Reactions

The use of amines and phosphines in nucleophilic catalysis is well precedented; however, arguably one of the severe limitations with respect to exploiting the more nucleophilic, yet less basic, phosphine in this regard is its air sensitivity.

Drying Agents

Many products such as aluminas, silicas and molecular sieves can be employed as reasonably effective drying agents which can usually be conveniently regenerated. Current chemical literature reflects an active interest in the drying process, and even the method by which

Asymmetric Reduction of Ketones

The enantioselective reduction of ketones to alcohols gives access to a pool of chiral building blocks that can be used for the synthesis of natural products. Adolfsson and co-workers reported a novel class of ligands, based on a pseudo-dipeptide, for

Scale-Up Guide: Suzuki-Miyaura Cross-Coupling Reaction

All of the preformed catalysts used in the kit are air and moisture stable complexes in their commercially available form.

Potassium Organotrifluoroborates

These bench stable Potassium Organotrifluoroborates are useful for Suzuki-Miyaura cross-coupling reactions and have also been used for a variety of other C-C bond forming reactions. Importantly, these reagents are compatible with a wide range of functional groups and are

Metal Scavengers

Metal compounds are widely used in organic and medicinal chemistry as either reactants or catalysts. Since most metal ions have physiological activities, reducing residual metal levels has become a key step in syntheses of bioactive compounds.

Montmorillonites and other Mineral Adsorbents

Montmorillonites Other

DABAL-Me3 - Non-pyrophoric Methyl Anion Equivalent

DABAL-Me3 is an adduct of trimethylaluminum and DABCO® that is a free-flowing solid that can be manipulated without the need for an inert atmosphere.

PYBOX Ligand - Large Binding Site & Rigid Scaffold

The PYBOX ligand, consisting of a pyridine ring flanked by two oxazoline groups, was introduced in 1989 by Nishiyama.

ChiPros Chiral Amines

Chiral amines play an important role in stereoselective organic synthesis. They are used directly as resolving agents, building blocks, or chiral auxiliaries.

Ionic Liquids Properties & Applications

Chiral Alcohols

Ionic Liquids

Ionic Liquids have experienced a comet-like boost in the last few years. In this edition of ChemFiles, we highlight some current applications of this fascinating class of new materials. We present over 50 new additions to our portfolio of 130+

Dess–Martin Periodinane

Dess-Martin Periodinane is used for the mild oxidation of alcohols to aldehydes and ketones. The neutral condition of the reaction makes DMP suitable for syntheses of sensitive, functionally complex intermediates.

QuinoxP*

QuinoxP*: Air-Stable and Highly Efficient and Productive Chiral Ligands

Solvent Stabilizer Systems

A description of stabilizer systems for solvents including esters, ethyl ester, tetrahydrofuran, chlorinated solvents, chloroform and dichloromethane.

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