Reaction design and optimization

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Glycosyltransferases: Tools for Synthesis and Modification of Glycans

Explore tools for glycosyltransferase synthesis and modification of glycans, such as glycosyltransferases and nucleotide sugar donors.

化学反应设计_化学反应优化_催化剂-默克生命科学

化学反应的设计和优化是有机合成研究的重要手段，通过改变反应参数，例如催化剂、反应体系pH值、反应溶剂、温度或时间等来节约成本、提高反应的选择性、产物的收率和纯度等

Trialkylphosphine for MBH Reactions

Amines and phosphines in nucleophilic catalysis are discussed, addressing the air sensitivity of phosphines.

N-Heterocyclic Carbene Ligands

A wide range of NHC ligands are commonly available which exhibit high activities.

CBS Catalysts

we are pleased to offer both enatiomers of 2-methyl-CBS-oxazaborolidine as a dry reagent, in addition to our current offerings as a 1M solution in toluene.

KitAlysis™ High-Throughput Screening Platform

KitAlysis High-Throughput Screening Kits provide solution to efficiently identify or optimize suitable catalytic reaction conditions. Chemist can rapidly run 24 unique micro scale reactions in parallel with tailored conditions.

Scale-Up Guide: Suzuki-Miyaura Cross-Coupling Reaction

All of the preformed catalysts used in the kit are air and moisture stable complexes in their commercially available form.

TPGS-750-M: Second-Generation Amphiphile for Organometallic Chemistry in Water at Room Temperature

Lipshutz and co-workers have recently developed a second generation technology to their original PTS-enabling surfactant based on the polyoxyethanyl-α-tocopheryl succinate derivative, TPGS-750-M.

Fluoroalkylation: Expansion of Togni Reagents

Fluoroalkylation toolbox expands with various reagents for late-stage fluoroalkylation in organic synthesis and medicinal chemistry.

Aldol Condensation Reaction

The aldol condensation reaction is an organic reaction introduced by Charles Wurtz, who first prepared the β-hydroxy aldehyde from acetaldehdye in 1872.

Baeyer-Villiger Oxidation Reaction

The Baeyer-Villiger oxidation is the oxidative cleavage of a carbon-carbon bond adjacent to a carbonyl, which converts the ketones to esters and the cyclic ketones to lactones.

Spirocyclic Building Blocks for Scaffold Assembly

Spirocyclic modules containing four-membered rings are currently of growing interest to discovery chemists.

Inverse Electron Demand Diels-Alder Reactions

Inverse electron demand Diels-Alder reactions enable total synthesis of natural products with heteroaromatic ring systems.

Synthia™ Organic Retrosynthesis Software - Resources

Learn more about Synthia™ Organic Retrosynthesis Software and view a list of publications.

KitAlysis™ Photocatalysis Reaction Screening Kit

PhotoKitAlysis Reaction Kit aids in cross-coupling reactions, offering pre-weighed components for optimization.

Scale-Up Guide: Photocatalysis Reaction

Scale-Up Guide for Photocatalysis Reaction to best enable scale-up success with High-Throughput Screening Kit.

KitAlysis High-Throughput Palladium Precatalyst Cross-Coupling Reaction Screening Kit

Materials Included in your KITALYSIS-24PD-2PK High-Throughput Screening Kit

AdQPhos and Pd pre catalysts for alpha arylation reaction

Discover AdQPhos and its Pd pre-catalysts for selective α-arylation of diverse nucleophiles under mild aqueous conditions without hazardous solvents.

Aerobic Alcohol Oxidation Solutions

Alcohol oxidation yields aldehydes and ketones, crucial intermediates in organic synthesis.

Aldehydes as Building Blocks

Synthesis of selective aldosterone synthase inhibitors using Wittig reaction with heterocyclic aldehydes described in study by Hartmann et al.

Alkali Metal Silica Gels from SiGNa

SiGNa Chemistry has recently developed a technology for encapsulating alkali metals into nano-structured porous oxides to create stable, free flowing powders with varying reactivities (based on the intended application).

Asymmetric Epoxidation Using Shi Catalyst

Catalytic asymmetric epoxidation of alkenes has been the focus of many research efforts over the past two decades, the best known methods probably being those developed by Sharpless and Jacobsen-Katsuki.

Asymmetric Reduction of Ketones

Novel ligands enable efficient ketone reduction for chiral building block synthesis.

Chiral Diene Ligands for Asymmetric Transformations

Chiral diene ligands enable asymmetric transformations, constructing enantioenriched compounds from achiral substrates efficiently.

Asymmetric Transfer Hydrogenation

The use of transfer hydrogenation to reduce alkenes, carboxyl groups, ketones, or imines has become very popular.

BASIONICS™ Ionic Liquids

BASIONICS™ Ionic Liquids offer diverse properties for varied applications in the BASF portfolio.

BINAP/SEGPHOS® Ligands and Complexes

We present an article concerning BINAP/SEGPHOS® Ligands and Complexes.

BINOL and Derivatives

We present an article concerning BINOL and Derivatives.

Bis(2-methoxyethyl)aminosulfur Trifluoride (Deoxo-Fluor®)

This technical article discusses Bis(2-methoxyethyl)aminosulfur Trifluoride (Deoxo-Fluor®).

Bis(pyridine)iodonium Tetrafluoroborate Usage

Bis(pyridine)iodonium tetrafluoroborate is a mild iodinating and oxidizing reagent reacting selectively with various substrates, tolerating functional groups.

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