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Showing 31-60 of 127 results for "gf77927170" within Papers
Shee Chien Yong et al.
Science (New York, N.Y.), 345(6201), 1170-1173 (2014-09-06)
Alkaline phosphatases play a crucial role in phosphate acquisition by microorganisms. To expand our understanding of catalysis by this class of enzymes, we have determined the structure of the widely occurring microbial alkaline phosphatase PhoX. The enzyme contains a complex
Yu Wang et al.
Biochimica et biophysica acta, 1840(10), 3022-3033 (2014-07-06)
The neurodegenerative disease Friedreich's ataxia is the result of frataxin deficiency. Frataxin is a mitochondrial protein involved in iron-sulfur cluster (Fe-S) cofactor biogenesis, but its functional role in this pathway is debated. This is due to the interconnectivity of iron
Robert F Anderson et al.
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 372(2019), 20130054-20130054 (2014-06-04)
Fluxes of lithogenic material and fluxes of three palaeo-productivity proxies (organic carbon, biogenic opal and alkenones) over the past 100,000 years were determined using the (230)Th-normalization method in three sediment cores from the Subantarctic South Atlantic Ocean. Features in the
Ramesh Kumar et al.
Environmental technology, 35(13-16), 2018-2027 (2014-06-25)
Nanofiltration (NF) of ammoniacal wastewater containing phenol and cyanide has been investigated for effective separation of these hazardous pollutants and for the subsequent downstream chemical treatment resulting in valuable by-product generation. Four different types of composite polyamide commercial NF membranes
Mary D Frame et al.
Nanotoxicology, 8(8), 867-875 (2013-09-03)
Single-walled carbon nanotubes synthesized with iron (Fe-SWCNT) or gadolinium (Gd-SWCNT) show promise as high performance multimodal contrast and drug-delivery agents. Our purpose was to evaluate potential vasoactive effects of SWCNT. Stable aqueous solutions of Fe-SWCNTs or Gd-SWCNTs were made using
Chenyan Lv et al.
Biochemistry, 53(14), 2232-2241 (2014-04-01)
From an evolutionary point of view, plant and animal ferritins arose from a common ancestor, but plant ferritin exhibits different features as compared with the animal analogue. One major difference is that the 4-fold channels naturally occurring in plant ferritin
Laura M van Staalduinen et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(14), 5171-5176 (2014-04-08)
The enzymes PhnY and PhnZ comprise an oxidative catabolic pathway that enables marine bacteria to use 2-aminoethylphosphonic acid as a source of inorganic phosphate. PhnZ is notable for catalyzing the oxidative cleavage of a carbon-phosphorus bond using Fe(II) and dioxygen
B Clevenger et al.
Anaesthesia, 70 Suppl 1, 20-28 (2014-12-03)
Pre-operative anaemia is a relatively common finding, affecting a third of patients undergoing elective surgery. Traditionally associated with chronic disease, management has historically focused on the use of blood transfusion as a solution for anaemia in the peri-operative period. Data
Janneke Balk et al.
Annual review of plant biology, 65, 125-153 (2014-02-07)
Iron is an essential element for all photosynthetic organisms. The biological use of this transition metal is as an enzyme cofactor, predominantly in electron transfer and catalysis. The main forms of iron cofactor are, in order of decreasing abundance, iron-sulfur
Yatrik M Shah et al.
Gastroenterology, 146(3), 630-642 (2014-01-07)
Iron is required for efficient oxygen transport, and hypoxia signaling links erythropoiesis with iron homeostasis. Hypoxia induces a highly conserved signaling pathway in cells under conditions of low levels of O2. One component of this pathway, hypoxia-inducible factor (HIF), is
Arnold L Demain et al.
Applied microbiology and biotechnology, 73(1), 55-59 (2006-04-20)
When tetanus toxin is made by fermentation with Clostridium tetani, the traditional source of iron is an insoluble preparation called reduced iron powder. This material removes oxygen from the system by forming FeO(2) (rust). When inoculated in a newly developed
Cecilia M Casadei et al.
Science (New York, N.Y.), 345(6193), 193-197 (2014-07-12)
Heme enzymes activate oxygen through formation of transient iron-oxo (ferryl) intermediates of the heme iron. A long-standing question has been the nature of the iron-oxygen bond and, in particular, the protonation state. We present neutron structures of the ferric derivative
D Cao et al.
Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc, 41(1), 27-31 (2014-03-22)
Iron is essential to life due to its unusual flexibility in serving as both an electron donor and acceptor. However, free iron can damage tissues by catalyzing the conversion of hydrogen peroxide to free-radical ions that attack lipids, proteins and
Jingrang Lu et al.
Journal of water and health, 12(4), 763-771 (2014-12-05)
A quantitative polymerase chain reaction assay (115 bp amplicon) specific to Escherichia coli K12 with an ABI(TM) internal control was developed based on sequence data encoding the rfb gene cluster. Assay specificity was evaluated using three E. coli K12 strains
Yan Zhang et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(17), E1695-E1704 (2014-04-16)
Eukaryotic ribonucleotide reductases (RNRs) require a diferric-tyrosyl radical (Fe(III)2-Y•) cofactor to produce deoxynucleotides essential for DNA replication and repair. This metallocofactor is an important target of RNR-based therapeutics, although mechanisms of in vivo cofactor assembly, inactivation, and reactivation are poorly
Ina Danquah et al.
Tropical medicine & international health : TM & IH, 19(5), 563-567 (2014-06-06)
Acute symptomatic infection with Giardia duodenalis impairs iron absorption, but iron deficiency may protect against infections caused by various micro-organisms including parasites. We therefore examined the association of G. duodenalis infection and iron deficiency in 575 Rwandan children under 5
50 years ago in the Journal of Pediatrics: Iron metabolism in premature infants: II. Prevention of iron deficiency.
Pamela J Kling
The Journal of pediatrics, 164(4), 768-768 (2014-03-22)
Kurinchi Selvan Gurusamy et al.
The Cochrane database of systematic reviews, 12(12), CD010640-CD010640 (2015-01-01)
Anaemia affects about a quarter of the world's population. An estimated 50% of anaemic people have anaemia due to iron deficiency. To assess the safety and efficacy of iron therapies for the treatment of adults with anaemia who are not
Keith P West et al.
JAMA, 312(24), 2649-2658 (2014-12-24)
Maternal micronutrient deficiencies may adversely affect fetal and infant health, yet there is insufficient evidence of effects on these outcomes to guide antenatal micronutrient supplementation in South Asia. To assess effects of antenatal multiple micronutrient vs iron-folic acid supplementation on
Reference method for measurement of the hepatic iron concentration.
Gary M Brittenham
American journal of hematology, 90(2), 85-86 (2014-12-10)
Thomas A Russo et al.
Infection and immunity, 82(6), 2356-2367 (2014-03-26)
Hypervirulent (hypermucoviscous) Klebsiella pneumoniae (hvKP) strains are an emerging variant of "classical" K. pneumoniae (cKP) that cause organ and life-threatening infection in healthy individuals. An understanding of hvKP-specific virulence mechanisms that enabled evolution from cKP is limited. Observations by our
Ellinor I B Peerschke et al.
American journal of clinical pathology, 142(4), 506-512 (2014-09-23)
Evaluation of anemia, particularly iron deficiency, in patients with cancer is difficult. This study examined using the hemoglobin content of reticulocytes (RET-He) to rule out iron deficiency, as defined by serum iron studies (transferrin saturation <20%, serum iron <40 μg/dL
[Children's iron needs and how we best can protect the child's brain].
Staffan Berglund et al.
Lakartidningen, 111(11), 460-463 (2014-04-12)
Theodore M Flynn et al.
Science (New York, N.Y.), 344(6187), 1039-1042 (2014-05-03)
Microbial reduction of ferric iron [Fe(III)] is an important biogeochemical process in anoxic aquifers. Depending on groundwater pH, dissimilatory metal-reducing bacteria can also respire alternative electron acceptors to survive, including elemental sulfur (S(0)). To understand the interplay of Fe/S cycling
Robert C Hider et al.
Metal ions in life sciences, 13, 229-294 (2014-01-29)
Iron is a redox active metal which is abundant in the Earth's crust. It has played a key role in the evolution of living systems and as such is an essential element in a wide range of biological phenomena, being
S J Geetha et al.
TheScientificWorldJournal, 2013, 315890-315890 (2013-12-10)
Under field conditions, inoculated rhizobial strains are at a survival disadvantage as compared to indigenous strains. In order to out-compete native rhizobia it is not only important to develop strong nodulation efficiency but also increase their competence in the soil
Sohail Amjad et al.
Pakistan journal of pharmaceutical sciences, 27(3), 445-452 (2014-05-09)
In Pakistan, a funded flour fortification program was launched for malnourished population, residing mainly in rural low income areas, but the urban population having comparatively better nutritional as well as economic status was focused wherein excessive intake of fortificants might
Darius J R Lane et al.
Biochimica et biophysica acta, 1845(2), 166-181 (2014-01-30)
Cancer is a major public health issue and, despite recent advances, effective clinical management remains elusive due to intra-tumoural heterogeneity and therapeutic resistance. Iron is a trace element integral to a multitude of metabolic processes, including DNA synthesis and energy
Zille Rubab et al.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 26(1), 19-25 (2015-01-13)
Patients on hemodialysis (HD) are usually anemic because of defective erythropoeisis. Hepcidin is a polypeptide that regulates iron homeostasis and could serve as an indicator of functional iron deficiency in patients with end-stage renal disease (ESRD); this may also aid
Eduard J van Beers et al.
Circulation research, 116(2), 298-306 (2014-11-08)
Patients with sickle cell disease (SCD) have markers of chronic inflammation, but the mechanism of inflammation and its relevance to patient survival are unknown. To assess the relationship between iron, inflammation, and early death in SCD. Using peripheral blood mononuclear
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