PHR1242

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Showing 1-30 of 234 results for "PHR1242" within Papers

Urinary and plasma organic acids and amino acids in chronic fatigue syndrome.

Mark G Jones et al.

Clinica chimica acta; international journal of clinical chemistry, 361(1-2), 150-158 (2005-07-05)

Previous work by others have suggested the occurrence of one or more chemical or metabolic 'markers' for ME/CFS including specific amino acids and organic acids and a number of unidentified compounds (CFSUM1, CFSUM2). We have shown elsewhere that CFSUM1 is

Diphenyl ditelluride-induced cell cycle arrest and apoptosis: a relation with topoisomerase I inhibition.

Patrícia M Jorge et al.

Basic & clinical pharmacology & toxicology, 116(3), 273-280 (2014-08-30)

The diphenyl ditelluride (DPDT) is a prototype for the development of new biologically active molecules. In previous studies, DPDT showed an elevated cytotoxicity in Chinese hamster fibroblast (V79) cells but the mechanisms for reduction of cell viability still remain unknown.

Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-induced activation.

Nisha Nanda et al.

The Journal of biological chemistry, 280(26), 24680-24689 (2005-04-27)

The present study was designed to identify novel membrane proteins that signal during platelet aggregation. Because one putative mechanism for signaling by a membrane protein involves phosphorylation, we used oligonucleotide-based microarray analyses and mass spectrometric proteomics techniques to specifically discover

Identification of ubiquitin-modified lysine residues and novel phosphorylation sites on eukaryotic initiation factor 2B epsilon.

Alexander P Tuckow et al.

Biochemical and biophysical research communications, 436(1), 41-46 (2013-05-28)

Eukaryotic initiation factor 2Bε (eIF2Bε) plays a critical role in the initiation of mRNA translation and its expression and guanine nucleotide exchange activity are major determinants of the rate of protein synthesis. In this work we provide evidence that the

L-threonine dehydrase as a model of allosteric control involving ligand-induced oligomerization.

C P Dunne et al.

Current topics in cellular regulation, 9, 65-101 (1975-01-01)

Cyclin-dependent kinase five mediates activation of lung xanthine oxidoreductase in response to hypoxia.

Bo S Kim et al.

PloS one, 10(4), e0124189-e0124189 (2015-04-02)

Xanthine oxidoreductase (XOR) is involved in oxidative metabolism of purines and is a source of reactive oxygen species (ROS). As such, XOR has been implicated in oxidant-mediated injury in multiple cardiopulmonary diseases. XOR enzyme activity is regulated, in part, via

[Regulation of receptor tyrosine kinases by Ser/Thr phosphorylation].

Yue Zhou et al.

Seikagaku. The Journal of Japanese Biochemical Society, 85(6), 462-468 (2013-07-24)

HIPK2 catalytic activity and subcellular localization are regulated by activation-loop Y354 autophosphorylation.

Francesca Siepi et al.

Biochimica et biophysica acta, 1833(6), 1443-1453 (2013-03-15)

HIPK2 (homeodomain-interacting protein kinase-2) binds to and phosphorylates, at Ser and Thr residues, a large number of targets involved in cell division and cell fate decision in response to different physiological or stress stimuli. Inactivation of HIPK2 has been observed

Acute tryptophan depletion reduces kynurenine levels: implications for treatment of impaired visuospatial memory performance in irritable bowel syndrome.

Paul J Kennedy et al.

Psychopharmacology, 232(8), 1357-1371 (2014-10-24)

A visuospatial episodic memory impairment has recently been identified in irritable bowel syndrome. Increased tryptophan metabolism along the kynurenine pathway has also been reported in irritable bowel syndrome, which may play a role in altered cognitive performance as peripheral kynurenine

Differential 12C-/13C-isotope dansylation labeling and fast liquid chromatography/mass spectrometry for absolute and relative quantification of the metabolome.

Kevin Guo et al.

Analytical chemistry, 81(10), 3919-3932 (2009-03-25)

We report a new quantitative metabolome profiling technique based on differential (12)C-/(13)C-isotope dansylation labeling of metabolites, fast liquid chromatography (LC) separation and electrospray ionization Fourier-transform ion cyclotron resonance mass spectrometry (ESI-FTICR MS) detection. An isotope reagent, (13)C-dansyl chloride, can be

The unique serine/threonine phosphatase from the minimal bacterium Mycoplasma synoviae: biochemical characterization and metal dependence.

Angela C O Menegatti et al.

Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 20(1), 61-75 (2014-11-06)

Serine/threonine protein phosphatases have been described in many pathogenic bacteria as essential enzymes involved in phosphorylation-dependent signal transduction pathways and frequently associated with the virulence of these organisms. An inspection of Mycoplasma synoviae genome revealed the presence of a gene

Function and control of RNA polymerase II C-terminal domain phosphorylation in vertebrate transcription and RNA processing.

Jing-Ping Hsin et al.

Molecular and cellular biology, 34(13), 2488-2498 (2014-04-23)

The C-terminal domain of the RNA polymerase II largest subunit (the Rpb1 CTD) is composed of tandem heptad repeats of the consensus sequence Y(1)S(2)P(3)T(4)S(5)P(6)S(7). We reported previously that Thr 4 is phosphorylated and functions in histone mRNA 3'-end formation in

Synthetic N- and O-glycosyl derivatives of L-asparagine, L-serine, and L-threonine.

H G Garg et al.

Advances in carbohydrate chemistry and biochemistry, 43, 135-201 (1985-01-01)

Oxidative stress induces phosphorylation of neuronal NOS in cardiomyocytes through AMP-activated protein kinase (AMPK).

Rekha Kar et al.

Biochemical and biophysical research communications, 459(3), 393-397 (2015-03-04)

Neuronal nitric oxide synthase (nNOS) plays a critical role in regulating cardiomyocyte function. nNOS was reported to decrease superoxide production in the myocardium by inhibiting the function of xanthine oxidoreductase. However, the effect of oxidative stress on nNOS in cardiomyocytes

1H and (13)C NMR spectroscopic analysis of human saliva.

C J L Silwood et al.

Journal of dental research, 81(6), 422-427 (2002-07-05)

We have explored the ability of high-resolution NMR techniques to (1) index salivary biomolecules and (2) provide valuable data regarding intra- and inter-subject variability in the concentrations of a series of components readily determinable by this technique (organic acids and

Monitoring of chemical elements and oxidative damage in patients affected by Alzheimer's disease.

Beatrice Bocca et al.

Annali dell'Istituto superiore di sanita, 41(2), 197-203 (2005-10-26)

The haematic concentration of 26 metals and the oxidative damage in 60 patients (20 males and 40 females) affected by Alzheimer's disease and 44 healthy individuals (33 males and 11 females) were compared. In patients, the following significant (p <

Clinical outcome according to the level of preexisting epidermal growth factor receptor T790M mutation in patients with lung cancer harboring sensitive epidermal growth factor receptor mutations.

Youngjoo Lee et al.

Cancer, 120(14), 2090-2098 (2014-04-17)

Epidermal growth factor receptor (EGFR) T790M mutation drives acquired drug resistance to EGFR tyrosine kinase inhibitors (EGFR-TKIs) in patients with EGFR-mutant lung cancer. However, it was reported that this mutation may exist before drug exposure. The objective of the current

Dietary L-arginine modulates immunosuppression in broilers inoculated with an intermediate strain of infectious bursa disease virus.

Jian-Zhuang Tan et al.

Journal of the science of food and agriculture, 95(1), 126-135 (2014-04-15)

The effects of dietary l-arginine (Arg) on immunosuppression following infectious bursal disease virus (IBDV) inoculation in broiler chickens were evaluated. The design of this study was a 5 × 2 factorial arrangement (n = 5) with five Arg concentrations (starter:

Phosphorylation-specific prolyl isomerization: is there an underlying theme?

Gerburg Wulf et al.

Nature cell biology, 7(5), 435-441 (2005-05-04)

The prolyl isomerase Pin1 is a conserved enzyme that is intimately involved in diverse biological processes and pathological conditions such as cancer and Alzheimer's disease. By catalysing cis-trans interconversion of certain motifs containing phosphorylated serine or threonine residues followed by

Prolonging the survival of Tsc2 conditional knockout mice by glutamine supplementation.

Natalia S Rozas et al.

Biochemical and biophysical research communications, 457(4), 635-639 (2015-01-24)

The genetic disease tuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by loss of function mutations in either TSC1 (hamartin) or TSC2 (tuberin), which serve as negative regulators of mechanistic target of rapamycin complex 1 (mTORC1) activity. TSC

De novo amino acid biosynthesis contributes to salmonella enterica growth in Alfalfa seedling exudates.

Grace Kwan et al.

Applied and environmental microbiology, 81(3), 861-873 (2014-11-25)

Salmonella enterica is a member of the plant microbiome. Growth of S. enterica in sprouting-seed exudates is rapid; however, the active metabolic networks essential in this environment are unknown. To examine the metabolic requirements of S. enterica during growth in

An N-terminal threonine mutation produces an efflux-favorable, sodium-primed conformation of the human dopamine transporter.

Rheaclare Fraser et al.

Molecular pharmacology, 86(1), 76-85 (2014-04-23)

The dopamine transporter (DAT) reversibly transports dopamine (DA) through a series of conformational transitions. Alanine (T62A) or aspartate (T62D) mutagenesis of Thr62 revealed T62D-human (h)DAT partitions in a predominately efflux-preferring conformation. Compared with wild-type (WT), T62D-hDAT exhibits reduced [(3)H]DA uptake

WMJ-S-001, a novel aliphatic hydroxamate derivative, exhibits anti-angiogenic activities via Src-homology-2-domain-containing protein tyrosine phosphatase 1.

Yi-Fang Chang et al.

Oncotarget, 6(1), 85-100 (2014-11-22)

Angiogenesis, one of the major routes for tumor invasion and metastasis represents a rational target for therapeutic intervention. Recent development in drug discovery has highlighted the diverse biological and pharmacological properties of hydroxamate derivatives. In this study, we characterized the

Structural biology. Structural basis for Notch1 engagement of Delta-like 4.

Vincent C Luca et al.

Science (New York, N.Y.), 347(6224), 847-853 (2015-02-24)

Notch receptors guide mammalian cell fate decisions by engaging the proteins Jagged and Delta-like (DLL). The 2.3 angstrom resolution crystal structure of the interacting regions of the Notch1-DLL4 complex reveals a two-site, antiparallel binding orientation assisted by Notch1 O-linked glycosylation.

Structure and function of enzymes involved in the anaerobic degradation of L-threonine to propionate.

Dhirendra K Simanshu et al.

Journal of biosciences, 32(6), 1195-1206 (2007-10-24)

In Escherichia coli and Salmonella typhimurium, L-threonine is cleaved non-oxidatively to propionate via 2-ketobutyrate by biodegradative threonine deaminase, 2-ketobutyrate formate-lyase (or pyruvate formate-lyase), phosphotransacetylase and propionate kinase. In the anaerobic condition, L-threonine is converted to the energy-rich keto acid and

[Role of serine/threonine and tyrosine protein phosphatases in command Helix lucorum neurons at the cellular correlate of habituation].

A S Pivovarov et al.

Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova, 63(2), 256-268 (2013-07-23)

Effects of some inhibitors of serine/threonine and tyrosine protein phosphatases on the depression and spontaneous recovery of the acetylcholine-induced inward current (ACh-current) in command Helix neurons of defensive behavior at the cellular correlate of habituation were investigated. The following drugs

Roles of serine and threonine residues of mumps virus P protein in viral transcription and replication.

Adrian Pickar et al.

Journal of virology, 88(8), 4414-4422 (2014-02-07)

Mumps virus (MuV), a paramyxovirus containing a negative-sense nonsegmented RNA genome, is a human pathogen that causes an acute infection with symptoms ranging from parotitis to mild meningitis and severe encephalitis. Vaccination against mumps virus has been effective in reducing

Runx2 activates PI3K/Akt signaling via mTORC2 regulation in invasive breast cancer cells.

Manish Tandon et al.

Breast cancer research : BCR, 16(1), R16-R16 (2014-02-01)

The Runt-related transcription factor Runx2 is critical for skeletal development but is also aberrantly expressed in breast cancers, and promotes cell growth and invasion. A de-regulated serine/threonine kinase Akt signaling pathway is implicated in mammary carcinogenesis and cell survival; however

Capillary electrophoresis with laser-induced fluorescence detection for studying amino acid uptake by yeast during beer fermentation.

Heidi Turkia et al.

Talanta, 131, 366-371 (2014-10-05)

The amino acid composition of cultivation broth is known to affect the biomass accumulation, productivity, and vitality of yeast during cultivation. A separation method based on capillary electrophoresis with laser-induced fluorescence (LIF) detection was developed for the determination of amino

Consequences of a deficit in vitamin B6 biosynthesis de novo for hormone homeostasis and root development in Arabidopsis.

Svetlana Boycheva et al.

Plant physiology, 167(1), 102-117 (2014-12-06)

Vitamin B(6) (pyridoxal 5'-phosphate) is an essential cofactor of many metabolic enzymes. Plants biosynthesize the vitamin de novo employing two enzymes, pyridoxine synthase1 (PDX1) and PDX2. In Arabidopsis (Arabidopsis thaliana), there are two catalytically active paralogs of PDX1 (PDX1.1 and

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