T4071

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Showing 1-30 of 335 results for "T4071" within Papers

Hydrogen sulphide decreases IL-1β-induced activation of fibroblast-like synoviocytes from patients with osteoarthritis.

Daniela Sieghart et al.

Journal of cellular and molecular medicine, 19(1), 187-197 (2014-10-15)

Balneotherapy employing sulphurous thermal water is still applied to patients suffering from diseases of musculoskeletal system like osteoarthritis (OA) but evidence for its clinical effectiveness is scarce. Since the gasotransmitter hydrogen sulphide (H2 S) seems to affect cells involved in

O-GlcNAc signaling in cancer metabolism and epigenetics.

Jay Prakash Singh et al.

Cancer letters, 356(2 Pt A), 244-250 (2014-04-29)

The covalent attachment of β-D-N-acetylglucosamine monosaccharides (O-GlcNAc) to serine/threonine residues of nuclear and cytoplasmic proteins is a major regulatory mechanism in cell physiology. Aberrant O-GlcNAc modification of signaling proteins, metabolic enzymes, and transcriptional and epigenetic regulators has been implicated in

The role of calcineurin signaling in microcystin-LR triggered neuronal toxicity.

Guangyu Li et al.

Scientific reports, 5, 11271-11271 (2015-06-11)

Microcystin-LR (MCLR) is a commonly acting potent hepatotoxin and has been pointed out of potentially causing neurotoxicity, but the exact mechanisms of action still remain unclear. Using proteomic analysis, forty-five proteins were identified to be significantly altered in hippocampal neurons

PI3Kγ integrates cAMP and Akt signalling of the μ-opioid receptor.

Sreedhar Madishetti et al.

British journal of pharmacology, 171(13), 3328-3337 (2014-03-25)

The μ-opioid receptor has been characterized as the main mediator of opioid signalling in neuronal cells. Opioid-induced pain suppression was originally proposed to be mediated by μ-opioid receptor-induced inhibitory effects on cAMP, which is known to mediate inflammatory hypernociception. Recent

Integrated 'omics analysis for studying the microbial community response to a pH perturbation of a cellulose-degrading bioreactor culture.

Amy A Boaro et al.

FEMS microbiology ecology, 90(3), 802-815 (2014-10-08)

Integrated 'omics have been used on pure cultures and co-cultures, yet they have not been applied to complex microbial communities to examine questions of perturbation response. In this study, we used integrated 'omics to measure the perturbation response of a

ROCK1 and 2 differentially regulate actomyosin organization to drive cell and synaptic polarity.

Karen A Newell-Litwa et al.

The Journal of cell biology, 210(2), 225-242 (2015-07-15)

RhoGTPases organize the actin cytoskeleton to generate diverse polarities, from front-back polarity in migrating cells to dendritic spine morphology in neurons. For example, RhoA through its effector kinase, RhoA kinase (ROCK), activates myosin II to form actomyosin filament bundles and

Mass fragmentography of 5-hydroxytryptophol and 5-methoxytryptophol in human cerebrospinal fluid.

H C Curtius et al.

Journal of chromatography, 112, 523-531 (1975-10-29)

A specific and very sensitive method for the determination of 5-hydroxy-tryptophol (5-HTOL) and 5-methoxytryptophol (5-MTOL) in extracts from human cerebrospinal fluid (CSF) involving the use of mass fragmentography and pentafluoropriopionyl derivatives is described. 5-HTOL and 5-MTOL were determined in human

Néstor-Guillermo Progeria Syndrome: a biochemical insight into Barrier-to-Autointegration Factor 1, alanine 12 threonine mutation.

Nicolas Paquet et al.

BMC molecular biology, 15, 27-27 (2014-12-17)

Premature aging syndromes recapitulate many aspects of natural aging and provide an insight into this phenomenon at a molecular and cellular level. The progeria syndromes appear to cause rapid aging through disruption of normal nuclear structure. Recently, a coding mutation

Quantitative analysis of 17 amino acids in tobacco leaves using an amino acid analyzer and chemometric resolution.

Yihang Zeng et al.

Journal of separation science, 38(12), 2053-2058 (2015-04-14)

A method was developed for quantifying 17 amino acids in tobacco leaves by using an A300 amino acid analyzer and chemometric resolution. In the method, amino acids were eluted by the buffer solution on an ion-exchange column. After reacting with

Phosphorylation of the kinase domain regulates autophosphorylation of myosin IIIA and its translocation in microvilli.

Byung Chull An et al.

Biochemistry, 53(49), 7835-7845 (2014-11-18)

Motor activity of myosin III is regulated by autophosphorylation. To investigate the role of the kinase activity on the transporter function of myosin IIIA (Myo3A), we identified the phosphorylation sites of kinase domain (KD), which is responsible for the regulation

Renal nerve stimulation leads to the activation of the Na+/H+ exchanger isoform 3 via angiotensin II type I receptor.

Roberto B Pontes et al.

American journal of physiology. Renal physiology, 308(8), F848-F856 (2015-02-07)

Renal nerve stimulation at a low frequency (below 2 Hz) causes water and sodium reabsorption via α1-adrenoreceptor tubular activation, a process independent of changes in systemic blood pressure, renal blood flow, or glomerular filtration rate. However, the underlying mechanism of

Pemetrexed induces S-phase arrest and apoptosis via a deregulated activation of Akt signaling pathway.

Kun-Chieh Chen et al.

PloS one, 9(5), e97888-e97888 (2014-05-23)

Pemetrexed is approved for first-line and maintenance treatment of patients with advanced or metastatic non-small-cell lung cancer (NSCLC). The protein kinase Akt/protein kinase B is a well-known regulator of cell survival which is activated by pemetrexed, but its role in

High resolution characterization of myosin IIC protein tailpiece and its effect on filament assembly.

Masha M Rosenberg et al.

The Journal of biological chemistry, 288(14), 9779-9789 (2013-02-22)

The motor protein nonmuscle myosin II (NMII) must undergo dynamic oligomerization into filaments to perform its cellular functions. A small nonhelical region at the tail of the long coiled-coil region (tailpiece) is a common feature of all dynamically assembling myosin

Late INa increases diastolic SR-Ca2+-leak in atrial myocardium by activating PKA and CaMKII.

Thomas H Fischer et al.

Cardiovascular research, 107(1), 184-196 (2015-05-21)

Enhanced cardiac late Na current (late INa) and increased sarcoplasmic reticulum (SR)-Ca(2+)-leak are both highly arrhythmogenic. This study seeks to identify signalling pathways interconnecting late INa and SR-Ca(2+)-leak in atrial cardiomyocytes (CMs). In murine atrial CMs, SR-Ca(2+)-leak was increased by

Abnormalities of whole body protein turnover, muscle metabolism and levels of metabolic hormones in patients with chronic heart failure.

H Nørrelund et al.

Journal of internal medicine, 260(1), 11-21 (2006-06-23)

It is well known that chronic heart failure (CHF) is associated with insulin resistance and cachexia, but little is known about the underlying substrate metabolism. The present study was undertaken to identify disturbances of basal glucose, lipid and protein metabolism.

Reduced cortical BACE1 content with one bout of exercise is accompanied by declines in AMPK, Akt, and MAPK signaling in obese, glucose-intolerant mice.

R E K MacPherson et al.

Journal of applied physiology (Bethesda, Md. : 1985), 119(10), 1097-1104 (2015-09-26)

Obesity and type 2 diabetes are significant risk factors in the development of neurodegenerative diseases, such as Alzheimer's disease. A variety of cellular mechanisms, such as altered Akt and AMPK and increased inflammatory signaling, contribute to neurodegeneration. Exercise training can

Akt Regulates TNFα synthesis downstream of RIP1 kinase activation during necroptosis.

Colleen R McNamara et al.

PloS one, 8(3), e56576-e56576 (2013-03-08)

Necroptosis is a regulated form of necrotic cell death that has been implicated in the pathogenesis of various diseases including intestinal inflammation and systemic inflammatory response syndrome (SIRS). In this work, we investigated the signaling mechanisms controlled by the necroptosis

Modulation of the intestinal environment, innate immune response, and barrier function by dietary threonine and purified fiber during a coccidiosis challenge in broiler chicks.

E L Wils-Plotz et al.

Poultry science, 92(3), 735-745 (2013-02-26)

Coccidiosis is a major contributor to economic losses in the poultry industry due to its detrimental effects on growth performance and nutrient utilization. We hypothesized that the combined effects of supplemental dietary Thr and purified fiber may modulate the intestinal

Sirt1 Regulates Microtubule Dynamics Through Negative Regulation of Plk1 in Mitosis.

Jin-Ju Kim et al.

Journal of cellular biochemistry, 116(9), 1888-1897 (2015-03-05)

Although loss of Sirt1 leads to chromosome aneuploidy, which accounts for higher tumor susceptibility, the molecular mechanisms remain unclear. Herein, we demonstrate that Sirt1 directly regulates Plk1, of which activity is critical for mitotic progression and spindle dynamics. Depletion or

CIP2A regulates cancer metabolism and CREB phosphorylation in non-small cell lung cancer.

Bo Peng et al.

Molecular bioSystems, 11(1), 105-114 (2014-10-18)

The cancerous inhibitor of protein phosphatase 2A (CIP2A) is a recently characterized endogenous inhibitor of the phosphatase activity of protein phosphatase 2A (PP2A), which extends the half-life of oncogenic protein c-myc and promotes in vivo tumor growth. The function of

Monoamine metabolites and amino acids in serum from schizophrenic patients before and during sulpiride treatment.

G Alfredsson et al.

Psychopharmacology, 99(3), 322-327 (1989-01-01)

Twenty-four acutely ill schizophrenic patients (DSM-III-R), 18-42 years old, were treated for 6 weeks with sulpiride. Sulpiride was administered in three different daily dosages (starting with 400, 800 or 1200 mg) according to a double blind randomized administration schedule. The

An enzymatic route to selenazolines.

Jesko Koehnke et al.

Chembiochem : a European journal of chemical biology, 14(5), 564-567 (2013-03-14)

Ringing the changes: Selenazolines have applications in medicinal chemistry, but their synthesis is challenging. We report a new convenient and less toxic route to these heterocycles that starts from commercially available selenocysteine. The new route depends on a heterocyclase enzyme

The anti-aging and tumor suppressor protein Klotho enhances differentiation of a human oligodendrocytic hybrid cell line.

Ci-Di Chen et al.

Journal of molecular neuroscience : MN, 55(1), 76-90 (2014-06-09)

Klotho functions as an aging suppressor, which, in mice, extends lifespan when overexpressed and accelerates development of aging-like phenotypes when disrupted. Klotho is mainly expressed in brain and kidney and is secreted into the serum and CSF. We have previously

Rational engineering of plasticity residues of sesquiterpene synthases from Artemisia annua: product specificity and catalytic efficiency.

Jian-Xu Li et al.

The Biochemical journal, 451(3), 417-426 (2013-02-27)

Most TPSs (terpene synthases) contain plasticity residues that are responsible for diversified terpene products and functional evolution, which provide a potential for improving catalytic efficiency. Artemisinin, a sesquiterpene lactone from Artemisia annua L., is widely used for malaria treatment and

Standardized Prunella vulgaris var. lilacina Extract Enhances Cognitive Performance in Normal Naive Mice.

Se Jin Park et al.

Phytotherapy research : PTR, 29(11), 1814-1821 (2015-09-18)

Adult hippocampal neurogenesis is closely associated with neuronal plasticity, cognitive function and the etiology of neurological diseases. We previously reported that the standardized ethanolic extract of Prunella vulgaris var. lilacina (EEPV) can be used for the prevention and treatment of

Phosphoacceptors threonine 162 and serines 170 and 178 within the carboxyl-terminal RRRS/T motif of the hepatitis B virus core protein make multiple contributions to hepatitis B virus replication.

Jaesung Jung et al.

Journal of virology, 88(16), 8754-8767 (2014-05-23)

Phosphorylation of serines 157, 164, and 172 within the carboxyl-terminal SPRRR motif of the hepatitis B virus (HBV) core (C) protein modulates HBV replication at multiple stages. Threonine 162 and serines 170 and 178, located within the carboxyl-terminal conserved RRRS/T

Newly identified minor phosphorylation site threonine-279 of measles virus nucleoprotein is a prerequisite for nucleocapsid formation.

Akihiro Sugai et al.

Journal of virology, 88(2), 1140-1149 (2013-11-08)

Measles virus nucleoprotein is the most abundant viral protein and tightly encapsidates viral genomic RNA to support viral transcription and replication. Major phosphorylation sites of nucleoprotein include the serine residues at locations 479 and 510. Minor phosphorylation residues have yet

Automated screening of urine samples for carbohydrates, organic and amino acids after treatment with urease.

J D Shoemaker et al.

Journal of chromatography, 562(1-2), 125-138 (1991-01-02)

Eighty-five clinical urine samples and nineteen urine samples previously found by other laboratories to suggest genetic metabolic defects were prepared for trimethylsilylation by treatment with urease, followed by azeotropic dehydration. The "Target Analyte Search" program provided with the VG Trio

Threonine-290 regulates nuclear translocation of the human pregnane X receptor through its phosphorylation/dephosphorylation by Ca2+/calmodulin-dependent protein kinase II and protein phosphatase 1.

Junko Sugatani et al.

Drug metabolism and disposition: the biological fate of chemicals, 42(10), 1708-1718 (2014-07-31)

The human pregnane X receptor (hPXR) is recognized as a xenobiotic-sensing nuclear receptor that transcriptionally regulates the gene expression of drug-metabolizing enzymes and transporters. Our study elucidates the mechanism by which the localization of hPXR is regulated through threonine-290. A

A structural snapshot of type II pilus formation in Streptococcus pneumoniae.

Md Munan Shaik et al.

The Journal of biological chemistry, 290(37), 22581-22592 (2015-07-23)

Pili are fibrous appendages expressed on the surface of a vast number of bacterial species, and their role in surface adhesion is important for processes such as infection, colonization, andbiofilm formation. The human pathogen Streptococcus pneumoniae expresses two different types

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