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  • Single hepatocellular carcinoma smaller than 2 cm: are ethanol injection and radiofrequency ablation equally effective?

Single hepatocellular carcinoma smaller than 2 cm: are ethanol injection and radiofrequency ablation equally effective?

Anticancer research (2015-01-01)
Maurizio Pompili, Nicoletta De Matthaeis, Antonio Saviano, Ilario De Sio, Giampiero Francica, Franco Brunello, Alessandro Cantamessa, Antonio Giorgio, Umberto Scognamiglio, Fabio Fornari, Francesco Giangregorio, Fabio Piscaglia, Silvia Gualandi, Eugenio Caturelli, Paola Roselli, Laura Riccardi, Gian Ludovico Rapaccini
PMID25550567
ABSTRACT

The impact of radiofrequency ablation (RFA) and percutaneous ethanol injection (PEI) on survival in patients with small hepatocellular carcinoma (HCC) is unclear. We compared their efficacy in cirrhotics with single HCC ≤2 cm. Two hundred forty-four cirrhotics with single HCC ≤2 cm treated with PEI (108 cases) or RFA (136 cases) were enrolled in the study. Eighty-one patients in each group were selected for propensity score matching analysis. The five-year survival was not significantly different (64.7% in PEI and 72.9% in RFA group) but the 5-year recurrence (73.3% in PEI and 49% in RFA group, p=0.023) and local tumor progression (49% in PEI and 30.1% in RFA group, p=0.018) were higher in the PEI group. PEI and RFA are equally effective in treating HCCs smaller than 2 cm in terms of 5-year survival, despite higher cumulative and local recurrence rates, in patients treated with PEI.

MATERIALS
Product Number
Brand
Product Description
277649
Sigma-Aldrich
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Supelco
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Ethanol-80, 80 mg/dL in H2O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant®
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