- Synthesis and evaluation of glyco-coated liposomes as drug carriers for active targeting in drug delivery systems.
Synthesis and evaluation of glyco-coated liposomes as drug carriers for active targeting in drug delivery systems.
Carbohydrate research (2014-12-17)
Akiharu Ueki, Keita Un, Yuka Mino, Mitsuru Yoshida, Shigeru Kawakami, Hiromune Ando, Hideharu Ishida, Fumiyoshi Yamashita, Mitsuru Hashida, Makoto Kiso
PMID25500195
ABSTRACT
Novel sugar-conjugated cholesterols, β-Gal-, α-Man-, β-Man-, α-Fuc-, and β-Man-6P-S-β-Ala-Chol, were synthesized and incorporated into liposomes. In vitro experiments using the glyco-coated liposomes showed that the glyco-coated liposomes are efficiently taken up by cells expressing carbohydrate-binding receptors selectively. Glyco-coated liposomes are promising candidates for drug delivery vehicles.
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
SyntheChol® NS0 Supplement, 500 ×, synthetic cholesterol, animal component-free, sterile-filtered, aqueous solution, suitable for cell culture
Pure Water Density Standard, UKAS ISO/IEC17025 and ISO Guide 34 certified, density: 0.9982 g/mL at 20 °C, density: 0.9970 g/mL at 25 °C
Sigma-Aldrich
Sodium hydroxide, puriss., meets analytical specification of Ph. Eur., BP, NF, E524, 98-100.5%, pellets