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Investigating the anti-leishmanial effects of linear peptoids.

Investigating the anti-leishmanial effects of linear peptoids.

ChemMedChem (2014-12-17)

Gabriela A Eggimann, Hannah L Bolt, Paul W Denny, Steven L Cobb

ABSTRACT

Peptoids, a class of peptide mimetics, have emerged as promising anti-infective agents against a range of bacterial infections. Herein we present the first study of the antiparasitic and specifically the anti-leishmanial properties of linear peptoids. Peptoids were identified as having promising activity against Leishmania mexicana axenic amastigotes, a causative agent of cutaneous leishmaniasis.

MATERIALS

Product Number

Brand

Product Description

Sigma-Aldrich

Bromoacetic acid, reagent grade, 97%

Sigma-Aldrich

N,N-Dimethylformamide, anhydrous, 99.8%

Sigma-Aldrich

N,N-Dimethylformamide, Molecular Biology, ≥99%

Sigma-Aldrich

Bromoacetic acid, ReagentPlus^®, ≥99.0%

Sigma-Aldrich

N,N-Dimethylformamide, ReagentPlus^®, ≥99%

Supelco

N,N-Dimethylformamide, analytical standard

Supelco

Dimethylformamide, Pharmaceutical Secondary Standard; Certified Reference Material

Sigma-Aldrich

N,N-Dimethylformamide, ACS reagent, ≥99.8%

Sigma-Aldrich

N,N-Dimethylformamide, puriss. p.a., ACS reagent, reag. Ph. Eur., ≥99.8% (GC)

Sigma-Aldrich

N,N-Dimethylformamide, biotech. grade, ≥99.9%

Sigma-Aldrich

N,N-Dimethylformamide, suitable for HPLC, ≥99.9%

Supelco

Trifluoroacetic acid, analytical standard

Sigma-Aldrich

Trifluoroacetic acid, puriss. p.a., suitable for HPLC, ≥99.0% (GC)

Sigma-Aldrich

Trifluoroacetic acid, ≥99%, for protein sequencing

Sigma-Aldrich

Trifluoroacetic acid, ReagentPlus^®, 99%

Sigma-Aldrich

Trifluoroacetic acid, suitable for HPLC, ≥99.0%