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Responsive foams for nanoparticle delivery.

Responsive foams for nanoparticle delivery.

Colloids and surfaces. B, Biointerfaces (2015-06-21)

Christina Tang, Edward Xiao, Patrick J Sinko, Zoltan Szekely, Robert K Prud'homme

ABSTRACT

We have developed responsive foam systems for nanoparticle delivery. The foams are easy to make, stable at room temperature, and can be engineered to break in response to temperature or moisture. Temperature-responsive foams are based on the phase transition of long chain alcohols and could be produced using medical grade nitrous oxide as a propellant. These temperature-sensitive foams could be used for polyacrylic acid (PAA)-based nanoparticle delivery. We also discuss moisture-responsive foams made with soap pump dispensers. Polyethylene glycol (PEG)-based nanoparticles or PMMA latex nanoparticles were loaded into Tween 20 foams and the particle size was not affected by the foam formulation or foam break. Using biocompatible detergents, we anticipate this will be a versatile and simple approach to producing foams for nanoparticle delivery with many potential pharmaceutical and personal care applications.

MATERIALS

Product Number

Brand

Product Description

Sigma-Aldrich

1-Hexadecanol, 95%

Sigma-Aldrich

1-Hexadecanol, ReagentPlus^®, 99%

Sigma-Aldrich

Tetrahydrofuran, anhydrous, ≥99.9%, inhibitor-free

Sigma-Aldrich

Propylene glycol, ≥99.5% (GC), FCC, FG

Sigma-Aldrich

1-Hexadecanol, ≥99%

Sigma-Aldrich

Tetrahydrofuran, anhydrous, contains 250 ppm BHT as inhibitor, ≥99.9%

Sigma-Aldrich

Ethanol Fixative 80% v/v, suitable for fixing solution (blood films)

Supelco

Ethanol standards 10% (v/v), 10 % (v/v) in H₂O, analytical standard

Sigma-Aldrich

Tetrahydrofuran, inhibitor-free, purification grade

Sigma-Aldrich

Propylene Glycol, meets USP testing specifications

Sigma-Aldrich

Ethyl alcohol, Pure, 190 proof, ACS spectrophotometric grade, 95.0%

Sigma-Aldrich

1-Octadecanol, 95%

Sigma-Aldrich

Ethyl alcohol, Pure, 190 proof, meets USP testing specifications

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L-Lysine monohydrochloride, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%

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L-Lysine monohydrochloride, reagent grade, ≥98% (HPLC)

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L-Lysine monohydrochloride, BioUltra, ≥99.5% (AT)

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1,2-Propanediol, puriss. p.a., ACS reagent, ≥99.5% (GC)

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1,2-Propanediol, meets analytical specification of Ph. Eur., BP, USP, ≥99.5%

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1,2-Propanediol, ACS reagent, ≥99.5%

Sigma-Aldrich

1,2-Propanediol, ReagentPlus^®, 99%

Sigma-Aldrich

Ethyl alcohol, Pure, 200 proof, anhydrous, ≥99.5%

Sigma-Aldrich

1-Octadecanol, ReagentPlus^®, 99%

Sigma-Aldrich

1,2-Propanediol, Vetec^™, reagent grade, 98%

Sigma-Aldrich

Potassium hydroxide, ≥99.95% trace metals basis

Sigma-Aldrich

Ethyl alcohol, Pure, 190 proof, ACS reagent, meets USP testing specifications, Excise Tax-free, Permit for use required

Sigma-Aldrich

Ethyl alcohol, Pure, 160 proof, Excise Tax-free, Permit for use required

Sigma-Aldrich

Ethyl alcohol, Pure, 200 proof, ACS reagent, meets USP testing specifications, Excise Tax-free, Permit for use required