Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D

Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D

Nature communications (2017-10-04)

David A Sykes, Holly Moore, Lisa Stott, Nicholas Holliday, Jonathan A Javitch, J Robert Lane, Steven J Charlton

ABSTRACT

Atypical antipsychotic drugs (APDs) have been hypothesized to show reduced extrapyramidal side effects (EPS) due to their rapid dissociation from the dopamine D

MATERIALS

Product Number

Brand

Product Description

A7861

Sigma-Aldrich

Asenapine maleate, ≥98% (HPLC)

Z0877

Sigma-Aldrich

Zotepine