Merck
CN

1.08307

SAFC

高纯度三(羟甲基)胺基甲烷(氨基丁三醇)

(Trometamol) high purity, EMPROVE® EXPERT, Ph. Eur., BP, ChP, JPC, USP

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别名:
三(羟甲基)氨基甲烷, 2-氨基-2-(羟甲基)-1,3-丙二醇, THAM, Tris 碱, 氨基丁三醇
线性分子式:
NH2C(CH2OH)3
CAS号:
分子量:
121.14
Beilstein:
741883
MDL编号:
EC索引号:
201-064-4

Agency

BP
ChP
JPC
Ph. Eur.
USP

质量水平

蒸汽压

0.0267 hPa ( 20 °C)

描述

EMPROVE® EXPERT Ph Eur,BP,JPC,USP,ACS

产品线

EMPROVE® EXPERT

形式

solid

pH值(酸碱度)

10.2-10.6 (20 °C, 6 g/L in H2O)

useful pH range

7-9

pKa (25 °C)

8.1

bp

219-220 °C/10 mmHg (lit.)
219-220 °C/13.3 hPa

mp

167-172 °C (lit.)

密度

1.35 g/cm3 at 23 °C

application(s)

liquid formulation
pharmaceutical
semi-solid formulation

储存温度

no temp limit

SMILES string

NC(CO)(CO)CO

InChI

1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2

InChI key

LENZDBCJOHFCAS-UHFFFAOYSA-N

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此商品
1.083861.02408252859
Tris(hydroxymethyl)aminomethane (Trometamol), EMPROVE® EXPERT, Ph. Eur., BP, ChP, JPC, USP

SAFC

1.08386

三(羟甲基)氨基甲烷

-
Tris(hydroxymethyl)aminomethane volumetric standard, secondary reference material for acidimetry, traceable to NIST Standard Reference Material (SRM) Certipur® Reag. Ph Eur,Reag. USP

Supelco

1.02408

三(羟甲基)氨基甲烷

-
Tris(hydroxymethyl)aminomethane ACS reagent, ≥99.8%

Sigma-Aldrich

252859

三(羟甲基)氨基甲烷

Essential Grade
product line

EMPROVE® EXPERT

product line

EMPROVE® EXPERT

product line

-

product line

-

form

solid

form

solid

form

solid

form

crystalline

pH

10.2-10.6 (20 °C, 6 g/L in H2O)

pH

10.2-10.6 (20 °C, 6 g/L in H2O)

pH

10.2-10.6 (20 °C, 6 g/L in H2O)

pH

-

mp

167-172 °C (lit.)

mp

167-172 °C (lit.)

mp

167-172 °C (lit.)

mp

167-172 °C (lit.)

density

1.35 g/cm3 at 23 °C

density

1.35 g/cm3 at 23 °C

density

1.35 g/cm3 at 23 °C

density

-

一般描述

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

应用

Tris(hydroxymethyl)aminomethane (Trometamol) is a commonly used buffer component in biomolecule downstream chromatography steps as well as final liquid formulation.
Due to its low polyoxymethylene limits, Tris(hydroxymethyl)aminomethane (Trometamol) Emprove® Expert is suitable for use at elevated concentrations without risking precipitation. Also, low microbial and endotoxin limits facilitate the use of this product in high-risk applications.

法律信息

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Slide 1 of 6

1 of 6

Tris base =99.9% (titration), abs., 100 mg/mL, 300 nm ≤0.015

Sigma-Aldrich

TRIS-RO

Tris 碱

Millipore

Millipore

LSKCTB500

Tris Buffer, 0.5 L

Trizma® base BioXtra, pH 10.5-12.0 (1 M in H2O), ≥99.9% (titration)

Sigma-Aldrich

T6791

Trizma ®

Trizma® base Primary Standard and Buffer, ≥99.9% (titration), crystalline

Sigma-Aldrich

T1503

Trizma ®

Sodium chloride EMPROVE® EXPERT, Ph. Eur., BP, JP, USP

SAFC

1.16224

氯化钠

Tromethamine meets USP testing specifications

Sigma-Aldrich

T6687

缓血酸胺

商品

Overcoming Excipient Risks and Challenges for Parenteral Formulations

This overview describes the challenges when developing parenteral formulations and strategies to overcome them and reduce the risk of production.

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