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Merck
CN

1.20091

SAFC

二氧化硅

EMPROVE® ESSENTIAL, Ph. Eur., NF

别名:

二氧化硅

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线性分子式:
SiO2
化学文摘社编号:
7631-86-9
分子量:
60.08
MDL编号:
MFCD00011232
UNSPSC代码:
12352201

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Agency

NF
Ph. Eur.

质量水平

500

产品线

EMPROVE® ESSENTIAL

表单

fine powder

粒径

17-25 μm (d50)

沸点

2230 °C (lit.)

mp

>1600 °C (lit.)
1710 °C

应用

pharmaceutical
pharmaceutical
solid formulation
solubility enhancement

储存温度

2-30°C

SMILES字符串

O=[Si]=O

InChI

1S/O2Si/c1-3-2

InChI key

VYPSYNLAJGMNEJ-UHFFFAOYSA-N

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相关类别

一般描述

With formulation challenges in mind, we have used particle engineering technologies to develop functional excipients specifically for solid dosage forms. The products in our Parteck® portfolio feature unique particle properties tailored for excellent performance in tableting processes, for specific drug delivery technologies, or for solubility enhancement. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

应用

Parteck® SLC excipient is an innovative silica drug carrier that enhances drug solubility thanks to its unique surface structure, which can stabilize the amorphous state. This is especially relevant for poor glass forming APIs, which can be difficult to stabilize with other formulation technologies. Parteck® SLC is also emerging as a first-in-class excipient to reduce the risk of unstable polymorphism and particle properties in drug development. In this application, Parteck® SLC can homogenize both properties in a template-based formulation approach, with robust and reliable results.

特点和优势

  • Solubility enhancement of APIs
  • Unparalleled stabilization of the amorphous solid state
  • Unique pore structure (6 nm diameter) and a very high surface area (500 m²/g)
  • Perfect fit to stabilize poor glass former molecules
  • Platform approach to manage API particle and polymorph variation
  • No specific equipment/extra capital invest needed to stabilize the amorphous form of APIs
  • High-end application support

包装

1200910300 // Wide necked plastic bottle in corrugated box
1200911000 // Wide necked plastic bottle in corrugated box
1200919025 // Standard PE bag in PE square drum

法律信息

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
PARTECK is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

13 - Non Combustible Solids

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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商品

Enhance Solubility With 3D Printing and Mesoporous Silica

Accelerate formulation of APIs with solubility challenges using additive manufacturing (3D printing) with mesoporous silica. Explore this case study!

Improving API Solubility with Mesoporous Silica

Discover how mesoporous silica enhances API solubility, unlocking the full potential of promising drugs with improved bioavailability.

API Solubility and Dissolution Enhancement Via Formulation

Our overview of API solubility and dissolution enhancement methods can help you decide between the many options to take during formulation.

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