提高溶解度：提高固体制剂的生物利用度
随着越来越多的在研活性药物成分（API）显示出低水溶性，溶解度增强方法在医药产品开发中的重要性与日俱增。由于没有放之四海而皆准的解决方案，因此必须根据原料药的特性、所需的最终剂型以及所要求的制剂性能来选择适当的微调方法。我们提供一系列创新辅料，通过制剂方法提高原料药的溶解度，并在早期开发阶段对原料药进行加工，从而提高最终药物产品的疗效。
我们的解决方案包括：
- 用于热熔挤出、喷雾干燥、提高片剂溶出率的专用辅料，以及具有独特表面结构的二氧化硅药物载体
- 用于盐和共晶体形成的 API 加工化学品
需要专家指导？联系我们的专家，探讨配方解决方案。
了解如何提高生产力和绩效
卓越的溶解度增强和稳定性
我们的 Parteck® MXP 系列聚乙烯醇聚合物经过专门设计和优化，适用于热熔挤出，可提高各种原料药的溶解度：
亲水润滑剂，性能可靠
我们的溶出率增强辅料还可用作强效水溶性亲水润滑剂--设计时充分考虑了现代固体制剂生产的需求。
多功能溶解度增强剂和颗粒工程
我们创新的 Parteck® SLC 介孔二氧化硅可用作溶解度增强剂，在纳米级孔隙中稳定化合物的可溶性和无定形形式。
Meglumine 两种等级，多种应用
有机碱 meglumine 可用作反离子，与原料药形成盐，或用作功能性赋形剂，以提高原料药的溶解度、改善原料药的稳定性并调节 pH 值。请选择您的等级：
All supported by the Emprove® Program with comprehensive documentation to speed up your way to the market.只要适用，我们的产品都符合主要药典的要求。
Products
相关资源
- Download: Formulation Handbook
In this formulation handbook, we have compiled information and formulation examples that can help you when developing your formulation.
- Article: API Solubility and Dissolution Enhancement Via Formulation
Our overview of API solubility and dissolution enhancement methods can help you decide between the many options to take during formulation.
- Article: Improving API Solubility
This article describes the solubility challenge presented by many small molecule APIs and strategies to overcome these issues during the formulation process.
- White Paper: The Developability Classification System (DCS): Enabling an Optimized Approach for Formulation of Poorly Soluble Molecules
This white paper explores the DCS, a recent advancement based on the BCS system.
- Parteck® MXP White Paper: Enhancing the Solubility of Active Pharmaceutical Ingredients Using Hot Melt Extrusion and Polyvinyl Alcohol
This white paper describes how hot melt extrusion, and a specially engineered grade of polyvinyl alcohol can be used to increase the solubility of DCS IIb molecules.
- Parteck® MXP Brochure: Two Polymers, Unparalleled Value
With two specifically engineered grades of polyvinyl alcohol, our Parteck® MXP polymers are optimal for generating high performing, solubility enhanced formulations via hot melt extrusion.
- Parteck® MXP White Paper: Improving the Bioavailability of Challenging APIs Using Hot Melt Extrusion with Polyvinyl Alcohol
This white paper focuses on using hot melt extrusion (HME) to modify the physical state of APIs with the aim of enhancing solubility by converting the poorly soluble drug from its crystalline form into a stabilized amorphous form.
- Parteck® PLX 188 White Paper: Poloxamer: A Simple and Powerful Solution for Accelerating Dissolution
This white paper introduces the concept of dissolution and discuss how poloxamers are a simple yet powerful formulation approach that can enhance dissolution rate, while minimizing resource requirements.
- Parteck® PLX 188 Brochure: Accelerate Dissolution
Enhance dissolution rate and lubrication with a single high-performance excipient.
- Parteck® SLC Brochure: Adsorb, Stabilize, and Enhance
Unlock amorphous solubility enhancement for even the most challenging compounds.
- Meglumine Brochure: Double Your Benefit with Meglumine
Applicable either as an advanced API intermediate or as a functional excipient.
- Sweeteners Brochure: Two Ways to Ace the Taste Test
Achieve stable formulations and clean, sugar-like taste with our high-intensity sweeteners.
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