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Merck
CN

BP578

地塞米松

British Pharmacopoeia (BP) Assay Standard

别名:

(11β,16α)-9-氟-11,17,21-三羟基-16-甲基孕甾-1,4-二烯-3,20-二酮, 9α-氟-16α-甲基-11β,17α,21-三羟基-1,4-妊娠双烯-3,20-二酮, 9α-氟-16α-甲基泼尼松龙, 泼尼松龙F

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关于此项目

经验公式(希尔记法):
C22H29FO5
化学文摘社编号:
分子量:
392.46
EC Number:
200-003-9
UNSPSC Code:
41116107
NACRES:
NA.24
Beilstein/REAXYS Number:
2066651
MDL number:
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InChI key

UREBDLICKHMUKA-CXSFZGCWSA-N

InChI

1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

SMILES string

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

grade

pharmaceutical primary standard

API family

dexamethasone

form

solid

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

BP

Gene Information

human ... NR3C1(2908)

application(s)

pharmaceutical
pharmaceutical small molecule

format

neat

storage temp.

2-8°C

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General description

该产品在交付时提供并符合现行药典规定。随附的本产品的所有支持信息,包括SDS和任何产品信息彩页,均遵照现行药典许可而编制和发布。
更多信息和支持,请见现行药典网站。

Application

地塞米松BP参考标准品设计用于USP规定的指定质量测试和检测。

也用于专著,例如:
  • 妥布霉素和地塞米松滴眼液、悬浮液
  • 地塞米松磷酸钠口服溶液
  • 氢化可的松琥珀酸钠注射液
  • 强的松片
  • 地塞米松滴眼液、悬浮液
  • 地塞米松磷酸钠滴眼液、溶液
  • 地塞米松和新霉素耳喷雾剂
  • 倍他米松片
  • 地塞米松片
  • Biochem/physiol Actions

    糖皮质激素抗炎剂
    糖皮质激素抗炎剂。 调节T细胞生存、生长和分化。抑制一氧化氮合酶活性的诱导。

    Other Notes

    可能适用相应的销售限制。

    pictograms

    Health hazard

    signalword

    Danger

    hcodes

    Hazard Classifications

    Repr. 1B

    存储类别

    6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

    wgk

    WGK 3

    flash_point_f

    Not applicable

    flash_point_c

    Not applicable

    法规信息

    监管及禁止进口产品
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    历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number

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    Alexandre Denoyer et al.
    Ophthalmology, 122(4), 669-676 (2014-12-03)
    To compare small incision lenticule extraction (SMILE) versus LASIK for post-refractive dry eye disease. Prospective, comparative, nonrandomized clinical study. Thirty patients scheduled for bilateral myopic SMILE and 30 age-, sex-, and refraction-matched patients scheduled for bilateral myopic LASIK were enrolled
    Michael J White et al.
    Cell, 159(7), 1549-1562 (2014-12-20)
    Activated caspases are a hallmark of apoptosis induced by the intrinsic pathway, but they are dispensable for cell death and the apoptotic clearance of cells in vivo. This has led to the suggestion that caspases are activated not just to kill
    A Keith Stewart et al.
    The New England journal of medicine, 372(2), 142-152 (2014-12-09)
    Lenalidomide plus dexamethasone is a reference treatment for relapsed multiple myeloma. The combination of the proteasome inhibitor carfilzomib with lenalidomide and dexamethasone has shown efficacy in a phase 1 and 2 study in relapsed multiple myeloma. We randomly assigned 792
    Sharon D'Souza et al.
    Investigative ophthalmology & visual science, 55(6), 3396-3402 (2014-05-08)
    New femtosecond laser platforms may reduce ocular surface interference and LASIK-associated dry eye. This study investigated tear protein profiles in subjects who underwent LASIK using two femtosecond lasers to assess differences in protein expression. This was a randomized interventional clinical
    D Rhebergen et al.
    Psychoneuroendocrinology, 51, 341-350 (2014-12-03)
    Altered functioning of the hypothalamic-pituitary-adrenal axis (HPA-axis) has been associated with depression, but findings have been inconsistent. Among older depressed persons, both hyperactivity and hypo-activity of the HPA-axis were demonstrated. However, most studies were population-based studies, with single cortisol measurements

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