PHR1011
对羟基苯甲酸乙酯
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
4-羟基苯甲酸乙酯, EP, 尼泊金乙酯
等级
certified reference material
pharmaceutical secondary standard
质量水平
Agency
traceable to Ph. Eur. E2425000
traceable to USP 1267000
API类
parabens
CofA
current certificate can be downloaded
技术
HPLC: suitable
gas chromatography (GC): suitable
沸点
297-298 °C (lit.)
mp
114-117 °C (lit.)
应用
cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
pharmaceutical (small molecule)
包装形式
neat
储存温度
2-8°C
SMILES字符串
CCOC(=O)c1ccc(O)cc1
InChI
1S/C9H10O3/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6,10H,2H2,1H3
InChI key
NUVBSKCKDOMJSU-UHFFFAOYSA-N
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一般描述
用于质量控制的制药二级标准品，为制药实验室和制造商制备内部工作标准品提供了一种方便、高性价比的替代方案。
应用
对羟基苯甲酸乙酯可用作药物参考标准品，用于通过高效液相色谱（HPLC）测定药物制剂中的分析物。
这些二级标准品是经过检验的认证标准物质(CRM)。它们适用于多种分析应用，包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他标定应用。
分析说明
These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.
其他说明
在我们的NMR在线平台ChemisTwin®上可以找到本品对应的数字化标准物质。您可使用ChemisTwin®上的数字等效品鉴定您的样品并进行定量分析（使用数字化外标）。可查看该物质的NMR谱图，只需点击几次鼠标，就能进行在线样品比对。欢迎点击了解更多，开启免费试用之旅。
想要查看本品的分析证书示例，请在下框中输入LRAC3158。这只是一个示例证书，可能与您收到的批次不符。
该认证标准物质（CRM）根据ISO 17034 和 ISO/IEC 17025进行生产和认证。有关此CRM使用的所有信息均可在分析证书上找到。
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Determination of combined p-hydroxy benzoic acid preservatives in a liquid pharmaceutical formulation by HPLC
Shabir GA.
Journal of Pharmaceutical and Biomedical Analysis, 34(1), 207-213 (2004)
Sawsan El Hussein et al.
Experimental dermatology, 16(10), 830-836 (2007-09-12)
Concern is continuously raised about the safety of parabens which are present in most of the cosmetic preparations. In this investigation, methyl-, ethyl-, propyl- and butyl paraben (MP, EP, PP, BP), in a commercial cosmetic lotion, were deposited on human
S Nicoli et al.
Journal of pharmaceutical sciences, 97(11), 4830-4839 (2008-03-05)
This work aims at investigating the nicotinamide (NA)-ethyl-paraben (EP) binary system both in solution and in the solid state. In particular, the apparent EP solubility in water was studied in the presence of different NA concentrations (between 0.28 and 1.64
Shinshi Oishi
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 42(11), 1845-1849 (2004-09-08)
Parabens are alkyl esters of p-hydroxybenzoic acid widely used as preservatives in foodstuffs, cosmetics toiletries and pharmaceuticals. These compounds are known to exert a weak estrogenic activity in estrogen receptor assays in vitro. In addition butyl and propyl parabens show
Suzanne Abbas et al.
Drug metabolism and pharmacokinetics, 25(6), 568-577 (2010-10-12)
Parabens (alkyl esters of 4-hydroxybenzoic acid) are widely used as preservatives in drugs, cosmetic products, and foodstuffs. Safety concerns have recently increased due to the potential health risks associated to exposure to large amounts of these substances. Biotransformation of parabens
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