PHR1108
L-组氨酸
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
(S)-2-氨基-3-(4-咪唑基)丙酸, NSC 137773
等级
certified reference material
pharmaceutical secondary standard
质量水平
Agency
traceable to Ph. Eur. H0750000
traceable to USP 1308505
API类
histidine
CofA
current certificate can be downloaded
技术
HPLC: suitable
gas chromatography (GC): suitable
mp
282 °C (dec.) (lit.)
应用
cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
pharmaceutical (small molecule)
包装形式
neat
储存温度
2-30°C
SMILES字符串
N[C@@H](Cc1c[nH]cn1)C(O)=O
InChI
1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1
InChI key
HNDVDQJCIGZPNO-YFKPBYRVSA-N
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一般描述
用于质量控制的制药二级标准品，为制药实验室和制造商制备内部工作标准品提供了一种方便、高性价比的替代方案。L-组氨酸是一种必需氨基酸，广泛存在于酶的活性部位。它可与金属离子结合，并可能有助于铜的运输。它还在蛋白质结合位点上对血红素基团、大分子和磷酸基团的结合起着重要作用。
应用
这些二级标准品是合格的认证标准物质（CRM）。它们适用于多种分析应用，包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。
生化/生理作用
组胺的前体,经组氨酸脱羧酶作用可生成组胺。
分析说明
These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.
其他说明
在我们的NMR在线平台ChemisTwin®上可以找到本品对应的数字化标准物质。您可使用ChemisTwin®上的数字等效品鉴定您的样品并进行定量分析（使用数字化外标）。可查看该物质的NMR谱图，只需点击几次鼠标，就能进行在线样品比对。欢迎点击了解更多，开启免费试用之旅。
要查看该材料的分析证书示例，请在下面的栏位中输入LRAA7159。这只是一个示例证书，可能不是您收到的批次。
该认证参考物质（CRM）根据 ISO 17034 和 ISO/IEC 17025 进行生产和认证。所有关于客户关系管理的信息都可以在分析证书上找到。
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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Journal of medicinal chemistry, 56(12), 4966-4974 (2013-05-23)
Engineered affibody molecules can be used for high contrast in vivo molecular imaging. Extending a recombinantly produced HER2 binding affibody molecule with a hexa-histidine tag allows for convenient purification by immobilized metal-ion affinity chromatography and labeling with [(99m)Tc(CO)3](+) but increases
H M Golder et al.
Journal of dairy science, 97(8), 5131-5150 (2014-06-03)
Ruminal bacterial community composition (BCC) and its associations with ruminal fermentation measures were studied in dairy heifers challenged with combinations of grain, fructose, and histidine in a partial factorial study. Holstein-Friesian heifers (n=30) were randomly allocated to 5 triticale grain-based
Urszula Kosinska Eriksson et al.
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