PHR1121
2-苯氧基乙醇
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
乙二醇一苯醚, 苯基乙二醇
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线性分子式:
C6H5OCH2CH2OH
化学文摘社编号:
分子量:
138.16
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
204-589-7
Beilstein/REAXYS Number:
1364011
MDL number:
产品名称
2-苯氧基乙醇, Pharmaceutical Secondary Standard; Certified Reference Material
InChI key
QCDWFXQBSFUVSP-UHFFFAOYSA-N
InChI
1S/C8H10O2/c9-6-7-10-8-4-2-1-3-5-8/h1-5,9H,6-7H2
SMILES string
OCCOc1ccccc1
grade
certified reference material
pharmaceutical secondary standard
agency
traceable to Ph. Eur. P0950000
traceable to USP 1526200
API family
phenoxyethanol
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
bp
244-246 °C
mp
11-13 °C
density
1.107 g/mL at 20 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
Quality Level
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Analysis Note
These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.
Application
药物二级标准品也可用于以下应用：
- 通过液相色谱-串联质谱（LC-MS/MS）测定大鼠血浆、尿液和7种不同组织样品中的苯氧乙醇及其主要代谢产物苯氧基乙酸
- 开发用于定量测定市售人疫苗中2-苯氧乙醇的反相超高效液相色谱（RP-UHPLC）法
- 通过高新液相色谱-光电二极管阵列- 电喷雾电离质谱法（HPLC-PDA-ESI/MS）筛查化妆产品（CPs）中17种应用广泛的防腐剂
- 进行奶油样品中醋酸氢化可的松和2-苯氧乙醇的薄层色谱（TLC）-密度测定
- 通过配备程序升温气化（PTV）进样口和火焰离子化检测器的气相色谱（GC）分析局部用制剂中的八种挥发性和半挥发性成分。
Disclaimer
本品不可用作全球生物杀灭剂法规监管的生物杀灭剂，包括但不限于：美国联邦杀虫剂、杀菌剂和灭鼠剂法(US EPA′s Federal Insecticide Fungicide and Rodenticide Act)、欧盟生物杀灭剂法规(European Biocidal Products Regulation)、加拿大虫害管理监管机构(Canada’s Pest Management Regulatory Agency)、土耳其生物杀灭剂法规(Turkey’s Biocidal Products Regulation)、韩国生物杀灭剂法(Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR))等。
General description
该认证标准物质（CRM）根据ISO 17034和ISO/IEC 17025生产和认证。有关本CRM用途的所有信息参见分析证书
用于质量控制的药物二级标准品，为制药实验室和制造商制备内部工作标准提供了一种方便、高性价比的替代方案。
2-苯氧乙醇是一种常用的广谱抗菌防腐剂，在化妆品和局部用药物制剂中使用的浓度范围为0.5–1.0%。 它通过抑制线粒体中电子传递与磷酸化反应的耦合来起作用，并破坏ATP合成。 它也阻断苹果酸脱氢酶的活性，并提高细胞膜对钾离子的通透性。
用于质量控制的药物二级标准品，为制药实验室和制造商制备内部工作标准提供了一种方便、高性价比的替代方案。
2-苯氧乙醇是一种常用的广谱抗菌防腐剂，在化妆品和局部用药物制剂中使用的浓度范围为0.5–1.0%。 它通过抑制线粒体中电子传递与磷酸化反应的耦合来起作用，并破坏ATP合成。 它也阻断苹果酸脱氢酶的活性，并提高细胞膜对钾离子的通透性。
Other Notes
在我们的NMR在线平台ChemisTwin®上可以找到本品对应的数字化标准物质。您可使用ChemisTwin®上的数字等效品鉴定您的样品并进行定量分析（使用数字化外标）。可查看该物质的NMR谱图，只需点击几次鼠标，就能进行在线样品比对。欢迎点击了解更多，开启免费试用之旅。
想要查看本品的分析证书示例，请在下框中输入LRAC2814。这只是一个示例证书，可能与您收到的批次不符。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - STOT SE 3
target_organs
Respiratory system
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
258.8 °F - closed cup
flash_point_c
126 °C - closed cup
Simultaneous densitometric determination of hydrocortisone acetate and 2-phenoxyethanol in creams
Widiretani D, et al.
JPC-Journal of Planar Chromatography-Modern TLC, 26, 37-42 (2013)
Santosh K Tripathi et al.
Organic & biomolecular chemistry, 9(2), 581-587 (2010-11-05)
Syntheses of several diorganodiselenides and, in particular, a seven-membered cyclic seleninate ester derived from 2-phenoxyethanol are described. The seleninate ester was obtained from allyl (2-(2-hydroxyethoxy)phenyl) selenide through a series of oxidation and [2,3] sigmatropic rearrangement steps. The ester exhibits good
Jessica Stahl et al.
International wound journal, 7(1), 62-69 (2010-04-23)
A combination of 0.1% octenidine dihydrochloride and 2% 2-phenoxyethanol (octenisept) is a commonly used disinfectant in human medicine. As porcine skin represents an adequate model for human skin, the effect of octenidine dihydrochloride and phenoxyethanol on wound healing is studied
Shao-Ping Weng et al.
Reproductive toxicology (Elmsford, N.Y.), 29(4), 452-457 (2010-04-13)
Ethylene glycol monomethyl ether (EGME) is known to alter the reproductive function of exposed animals and their offspring; however, its influence on cumulus-oocyte complexes (COCs) remains unclear. This study assessed the toxicity of EGME on oocytes and COCs by analyzing
M Rosa Pena Ferreira et al.
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 16(4), 444-449 (2010-10-07)
Age has a huge influence on skin roughness; with increasing age, the number of collagen and elastine fibers is reduced and elasticity decreases significantly. Pharmaceutical and cosmetics, environmental factors and lifestyle have an important effect on skin. In this study
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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