PHR1152
水杨酸苯酯熔点标准品
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
水杨酸苯酯, 萨罗
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线性分子式:
2-(HO)C6H4CO2C6H5
化学文摘社编号:
分子量:
214.22
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
204-259-2
Beilstein/REAXYS Number:
393969
MDL number:
产品名称
水杨酸苯酯熔点标准品, Pharmaceutical Secondary Standard; Certified Reference Material
grade
certified reference material
pharmaceutical secondary standard
InChI key
ZQBAKBUEJOMQEX-UHFFFAOYSA-N
InChI
1S/C13H10O3/c14-12-9-5-4-8-11(12)13(15)16-10-6-2-1-3-7-10/h1-9,14H
SMILES string
Oc1ccccc1C(=O)Oc2ccccc2
agency
traceable to USP 1534209
API family
phenyl salicylate
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
bp
172-173 °C/12 mmHg (lit.)
mp
~Approximately 42 °C
41-43 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
Quality Level
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Analysis Note
These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.
Application
Phenyl salicylate may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations by chromatographic and spectrophotometric techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
General description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Phenyl salicylate is a phenyl ester of salicylic acid and is used as a medicine under the name ′salol′ as an internal antiseptic. It finds its application in paints, waxes, and varnishes as it is found to absorb UV radiation in the range of 290-325 nm. It also shows its presence in cosmetics and sunscreens as a UV filter.
Phenyl salicylate is a phenyl ester of salicylic acid and is used as a medicine under the name ′salol′ as an internal antiseptic. It finds its application in paints, waxes, and varnishes as it is found to absorb UV radiation in the range of 290-325 nm. It also shows its presence in cosmetics and sunscreens as a UV filter.
Other Notes
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA7176 in the slot below. This is an example certificate only and may not be the lot that you receive.
Values of analytes vary lot to lot.
signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
230.0 °F - closed cup
flash_point_c
110 °C - closed cup
Selective synthesis of phenyl salicylate (salol) by esterification reaction over solid acid catalysts
Kuriakose G and Nagaraju N
J. Mol. Catal. A: Chem., 223(1-2), 155-159 (2004)
Chemical analysis and ecotoxicological effects of organic UV-absorbing compounds in aquatic ecosystems
Diaz-Cruz MS and Barcelo Damia
TrAC, Trends in Analytical Chemistry, 28(6), 708-717 (2009)
An examination of the thermodynamics of fusion, vaporization, and sublimation of several parabens by correlation gas chromatography
Umnahanant P and Chickos J
Journal of Pharmaceutical Sciences, 100(5), 1847-1855 (2011)
Use of 1H NMR to facilitate solubility measurement for drug discovery compounds
Lin M, et al.
International Journal of Pharmaceutics, 369(1-2), 47-52 (2009)
Simultaneous determination of the UV-filters benzyl salicylate, phenyl salicylate, octyl salicylate, homosalate, 3-(4-methylbenzylidene) camphor and 3-benzylidene camphor in human placental tissue by LC-MS/MS. Assessment of their in vitro endocrine activity
Jimenez-Diaz I, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 936(6), 80-87 (2013)
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