产品名称
头孢唑啉, Pharmaceutical Secondary Standard; Certified Reference Material
SMILES string
[s]1c(nnc1C)SCC2=C(N3[C@H](SC2)[C@@H](C3=O)NC(=O)C[n]4nnnc4)C(=O)O
InChI
1S/C14H14N8O4S3/c1-6-17-18-14(29-6)28-4-7-3-27-12-9(11(24)22(12)10(7)13(25)26)16-8(23)2-21-5-15-19-20-21/h5,9,12H,2-4H2,1H3,(H,16,23)(H,25,26)/t9-,12-/m1/s1
InChI key
MLYYVTUWGNIJIB-BXKDBHETSA-N
grade
certified reference material
pharmaceutical secondary standard
agency
traceable to Ph. Eur. C0682800
traceable to USP 1097603
API family
cefazolin
CofA
current certificate can be downloaded
packaging
pkg of 500 mg
application(s)
pharmaceutical
format
neat
storage temp.
2-8°C
Quality Level
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Analysis Note
These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.
Application
Cefazolin has been used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by thin layer chromatography-densitometry technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
General description
Cefazolin is a first-generation cephalosporin β-lactam antibiotic drug that exhibits broad-spectrum antimicrobial activity against Klebsiella pneumoniae. It also acts in vitro against Gram-positive aerobic cocci while shows only a limited action on Gram-negative bacteria.
Pharmaceutical secondary standard for application in quality control. Provides pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical secondary standard for application in quality control. Provides pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB0131 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.
signalword
Danger
hcodes
Hazard Classifications
Resp. Sens. 1 - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
Voltammetric behavior and assay of the antibiotic drug cefazolin sodium in bulk form and pharmaceutical formulation at a mercury electrode
El-Desoky HS, et al.
Journal of Pharmaceutical and Biomedical Analysis, 39(5), 1051-1056 (2005)
Simultaneous identification and quantitative analysis of eight cephalosporins in pharmaceutical formulations by TLC-densitometry
Monika D, et al.
JPC-Journal of Planar Chromatography-Modern TLC, 24(1), 23-29 (2011)
Streamlining methodology for the multiresidue analysis of β -lactam antibiotics in bovine kidney using liquid chromatography-tandem mass spectrometry
Mastovska K and Lightfield AR
Journal of Chromatography A, 1202(2), 118-123 (2008)
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