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文件

PHR1388

阿达帕林

Name: 阿达帕林
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

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别名:

阿达帕林

经验公式（希尔记法）:

C₂₈H₂₈O₃

CAS号:

106685-40-9

分子量:

412.52

MDL编号:

MFCD03106112

PubChem化学物质编号:

329823363

NACRES:

NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to Ph. Eur. Y0001121
traceable to USP 1011709

API类

adapalene

CofA

current certificate can be downloaded

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

pharmaceutical (small molecule)

格式

neat

储存温度

2-30°C

SMILES字符串

COc1ccc(cc1C23C[C@H]4C[C@H](C[C@H](C4)C2)C3)-c5ccc6cc(ccc6c5)C(O)=O

InChI

1S/C28H28O3/c1-31-26-7-6-23(21-2-3-22-12-24(27(29)30)5-4-20(22)11-21)13-25(26)28-14-17-8-18(15-28)10-19(9-17)16-28/h2-7,11-13,17-19H,8-10,14-16H2,1H3,(H,29,30)/t17-,18+,19-,28-

InChI key

LZCDAPDGXCYOEH-AADAIPAGSA-N

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一般描述

Adapalene is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

应用

Adapalene may be used as a pharmaceutical reference standard for the quantification of the analyte in topical gel formulations using high-performance liquid chromatography technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化/生理作用

Retinoic acid analogue that is a RARβ and RARγ agonist (AC50 values are 2.2, 9.3, 22 and > 1000 nM for RARβ, RARγ, RARα and RXRα receptors respectively). Inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro. Displays comedolytic activity. Its unique pharmacological properties make it superior to other retinoids for the treatment of acne.

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAC3530 in the slot below. This is an example certificate only and may not be the lot that you receive.

1011710

6-溴-2-萘甲酸甲酯, United States Pharmacopeia (USP) Reference Standard

1011709

阿达帕林, United States Pharmacopeia (USP) Reference Standard

1011721

1011732

1011743

1011754

PHR2828

PHR2829

PHR2830

象形图

GHS08

警示用语：

Warning

危险声明

H361d

预防措施声明

P201 - P202 - P280 - P308 + P313 - P405 - P501

危险分类

Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

其它示例：

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

输入内容 1.000309185)

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如何查找COA批号

批号可以在产品标签上"批“ （Lot或Batch）字后面找到。

Aldrich 产品

如果您查询到的批号为 TO09019TO 等，请输入去除前两位字母的批号：09019TO。
如果您查询到的批号含有填充代码（例如05427ES-021），请输入去除填充代码-021的批号：05427ES。
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索取COA

Novel stability-indicating RP-HPLC method for the simultaneous estimation of clindamycin phosphate and adapalene along with preservatives in topical gel formulations

Modi.BP and Shah.JN

Scientia Pharmaceutica, 82(4), 799-814 (2014)

A simple HPLC-DAD method for determination of adapalene in topical gel formulation

Martins AL, et al.

Journal of Chromatographic Science, 49(10), 796-800 (2011)

Adapalene: an update on newer comparative studies between the various retinoids.

L E Millikan

International journal of dermatology, 39(10), 784-788 (2000-11-30)

Extensive modification of the retinoic acid molecular skeleton has resulted in the development of adapalene, a more stable, less irritating compound with receptor selectivity. Adapalene selectively targets nuclear retinoic acid receptors found primarily in the epidermis. Pharmacologic and preclinical studies

A review of adapalene in the treatment of acne vulgaris.

Cynthia E Irby et al.

The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 43(5), 421-424 (2008-10-14)

Topical retinoids help address the early lesions of acne vulgaris. Consensus guidelines advocate the use of topical retinoids as the primary treatment for most forms of acne vulgaris. However, all topical retinoid preparations may be irritating, and this may contribute

Pivotal clinical trials of adapalene in the treatment of acne.

L E Millikan

Journal of the European Academy of Dermatology and Venereology : JEADV, 15 Suppl 3, 19-22 (2002-02-15)

Adapalene, a naphthoic-acid derivative, possesses some of the biological activities of tretinoin but has distinct physicochemical properties and binding properties for selective affinity for retinoic acid receptors. As such, adapalene is less likely to be associated with certain local tolerability

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文件

阿达帕林

Pharmaceutical Secondary Standard; Certified Reference Material

属性

等级

质量水平

Agency

API类

CofA

技术

应用

格式

储存温度

SMILES字符串

InChI

InChI key

相关类别

说明

一般描述

应用

生化/生理作用

分析说明

其他说明

附注

相关产品

相关产品

安全信息

象形图

警示用语：

危险声明

预防措施声明

危险分类

储存分类代码

WGK

闪点(°F)

闪点(°C)

文件

分析证书(COA)

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