PHR1464
氨苯砜
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
4-氨基苯砜, 4,4′-二氨基二苯砜, 4,4′-磺酰基二苯胺, DDS, 双(4-氨基苯基)砜, 氨苯砜
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线性分子式:
(H2NC6H4)2SO2
化学文摘社编号:
分子量:
248.30
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
201-248-4
Beilstein/REAXYS Number:
788055
MDL number:
InChI key
MQJKPEGWNLWLTK-UHFFFAOYSA-N
InChI
1S/C12H12N2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H,13-14H2
SMILES string
Nc1ccc(cc1)S(=O)(=O)c2ccc(N)cc2
grade
certified reference material, pharmaceutical secondary standard
agency
traceable to Ph. Eur. D0100000, traceable to USP 1164008
API family
dapsone
CofA
current certificate can be downloaded
packaging
pkg of 1 g
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
mp
175-177 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
Quality Level
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General description
Dapsone is an antibacterial drug, belongs to a class of compounds known as sulfones. It acts by inhibiting the synthesis of dihydrofolic acid through competition with para-aminobenzoate for the active site of dihydropteroate synthetase, thereby inhibiting the growth of microorganisms that are dependent on endogenous folic acid synthesis. It is used in primary treatment of dermatitis herpetiformis and in combination with other drugs to treat leprosy.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Application
Dapsone may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug, human plasma, tablets and pharmaceutical formulations by chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Analysis Note
These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA3012 in the slot below. This is an example certificate only and may not be the lot that you receive.
signalword
Danger
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 2 - Repr. 1B - STOT RE 2 - STOT SE 2
target_organs
Blood, Blood,spleen,Liver
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Dapsone and sulfones in dermatology: overview and update
Zhu YI and Stiller MJ
Journal of the American Academy of Dermatology, 45(3), 420-434 (2001)
An ecofriendly and stability-indicating RP-HPLC method for determination of dapsone: Application to pharmaceutical analysis
Beheshti ML, et al.
Chiang Mai Journal of Science, 43(3), 620-629 (2016)
Validated TLC and HPLC stability-indicating methods for the quantitative determination of dapsone
Salama N, et al.
JPC-Journal of Planar Chromatography-Modern TLC, 25(1), 65-71 (2012)
Chunjuan Yang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 960, 59-66 (2014-05-03)
Corynoline and acetycorynoline are active compounds of Corydalis bungeana Turcz. with various pharmacological effects such as sedation, anti-leptospira and liver injury protection effects. A specific, simple and sensitive UHPLC-ESI-MS/MS method was developed and validated for the pharmacokinetic study of corynoline
Hom-Lay Wang et al.
Journal of periodontology, 85(12), 1693-1701 (2014-06-27)
The purpose of this multicenter randomly controlled clinical trial was to compare two acellular dermal matrix (ADM) materials produced by different processing techniques, freeze-dried (FDADM) and solvent-dehydrated (SDADM) ADM, in their ability to correct Miller Class I and II recession
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