Merck
CN
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文件

PHR1464

Supelco

氨苯砜

Pharmaceutical Secondary Standard; Certified Reference Material

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别名:
4-氨基苯砜, 4,4'-二氨基二苯砜, 4,4′-磺酰基二苯胺, DDS, 双(4-氨基苯基)砜, 氨苯砜
线性分子式:
(H2NC6H4)2SO2
CAS号:
80-08-0
分子量:
248.30
Beilstein:
788055
EC 号:
201-248-4
MDL编号:
MFCD00007887
PubChem化学物质编号:
329823395
NACRES:
NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to BP 102
traceable to Ph. Eur. D0100000
traceable to USP 1164008

API类

dapsone

CofA

current certificate can be downloaded

包装

pkg of 1 g

技术

HPLC: suitable
gas chromatography (GC): suitable

mp

175-177 °C (lit.)

应用

pharmaceutical (small molecule)

格式

neat

储存温度

2-30°C

SMILES字符串

Nc1ccc(cc1)S(=O)(=O)c2ccc(N)cc2

InChI

1S/C12H12N2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H,13-14H2

InChI key

MQJKPEGWNLWLTK-UHFFFAOYSA-N

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相关类别

一般描述

Dapsone is an antibacterial drug, belongs to a class of compounds known as sulfones. It acts by inhibiting the synthesis of dihydrofolic acid through competition with para-aminobenzoate for the active site of dihydropteroate synthetase, thereby inhibiting the growth of microorganisms that are dependent on endogenous folic acid synthesis. It is used in primary treatment of dermatitis herpetiformis and in combination with other drugs to treat leprosy.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

应用

Dapsone may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA3012 in the slot below. This is an example certificate only and may not be the lot that you receive.

推荐产品

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

警示用语：

Danger

危险分类

Acute Tox. 4 Oral - Aquatic Chronic 2 - Repr. 1B - STOT RE 2 - STOT SE 2

靶器官

Blood

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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货号
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25G
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Validated TLC and HPLC stability-indicating methods for the quantitative determination of dapsone
Salama N, et al.
JPC-Journal of Planar Chromatography-Modern TLC, 25(1), 65-71 (2012)
Dapsone and sulfones in dermatology: overview and update
Zhu YI and Stiller MJ
Journal of the American Academy of Dermatology, 45(3), 420-434 (2001)
An ecofriendly and stability-indicating RP-HPLC method for determination of dapsone: Application to pharmaceutical analysis
Beheshti ML, et al.
Chiang Mai Journal of Science, 43(3), 620-629 (2016)
Chunjuan Yang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 960, 59-66 (2014-05-03)
Corynoline and acetycorynoline are active compounds of Corydalis bungeana Turcz. with various pharmacological effects such as sedation, anti-leptospira and liver injury protection effects. A specific, simple and sensitive UHPLC-ESI-MS/MS method was developed and validated for the pharmacokinetic study of corynoline
Hom-Lay Wang et al.
Journal of periodontology, 85(12), 1693-1701 (2014-06-27)
The purpose of this multicenter randomly controlled clinical trial was to compare two acellular dermal matrix (ADM) materials produced by different processing techniques, freeze-dried (FDADM) and solvent-dehydrated (SDADM) ADM, in their ability to correct Miller Class I and II recession
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