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Merck
CN

PHR1509

酒石酸肾上腺素

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

(-)-肾上腺素 (+)-酒石酸氢盐, 酒石酸肾上腺素, 副肾素 (+)-酒石酸氢盐, L-3,4-Dihydroxy-α-(methylaminomethyl)benzyl alcohol D-hydrogen 酒石酸氢盐, L-Adrenaline D-hydrogentartrate

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关于此项目

经验公式（希尔记法）:
C9H13NO3 · C4H6O6
化学文摘社编号:
51-42-3
分子量:
333.29
NACRES:
NA.24
PubChem Substance ID:
329823427
UNSPSC Code:
41116107
EC Number:
200-097-1
MDL number:
MFCD00035077

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InChI key

YLXIPWWIOISBDD-NDAAPVSOSA-N

InChI

1S/C9H13NO3.C4H6O6/c1-10-5-9(13)6-2-3-7(11)8(12)4-6;5-1(3(7)8)2(6)4(9)10/h2-4,9-13H,5H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t9-;1-,2-/m01/s1

SMILES string

O[C@H]([C@@H](O)C(O)=O)C(O)=O.CNC[C@H](O)c1ccc(O)c(O)c1

grade

certified reference material, pharmaceutical secondary standard

agency

USP 1237000, traceable to Ph. Eur. A0300000

API family

epinephrine

CofA

current certificate can be downloaded

packaging

ampule of 500 mg

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), ADRB1(153), ADRB2(154), ADRB3(155)

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相关类别

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Epinephrine belongs to the class of drugs termed as catecholamines, which exerts its action on both alpha and beta-adrenergic receptors using a G protein-linked second messenger system.

Application

Epinephrine bitartrate may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

肾上腺素能受体激动剂。

Other Notes

To see an example of a Certificate of Analysis for this material enter LRAC0282 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H300

Hazard Classifications

Acute Tox. 1 Oral

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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A reversed-phase high performance liquid chromatographic method for determination of Epinephrine in pharmaceutical formulation
Mishra AK, et al
Archives of Applied Science Research, 2, 251-256 (2010)
Epinephrine
StatPearls [Internet] (2019)
Determination of catecholamines by flow-injection analysis and high-performance liquid chromatography with chemiluminescence detection
Nalewajko E, et al.
Journal of Pharmaceutical and Biomedical Analysis, 43(5), 1673-1681 (2007)
Quantitative high-pressure liquid chromatographic determination of epinephrine in pharmaceutical formulations
Fu CC and Sibley MJ
Journal of Pharmaceutical Sciences, 66(3), 425-426 (1977)
George Karkoulias et al.
Cellular signalling, 66, 109446-109446 (2019-11-05)
Many aspects of neuronal development, such as neuronal survival and differentiation, are regulated by the transcription factor cAMP-response element-binding protein (CREB). We have previously reported that α2-adrenergic receptors (ARs), members of the G protein-coupled receptor (GPCR) superfamily, induce neuronal differentiation

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