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Merck
CN

PHR1620

Supelco

氟伐他汀 钠

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

(3R,5S,6E)-rel-7-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid monosodium salt

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关于此项目

经验公式（希尔记法）:
C24H25FNNaO4
化学文摘社编号:
93957-55-2
分子量:
433.45
MDL编号:
MFCD08063391
UNSPSC代码:
41116107
PubChem化学物质编号:
329823514
NACRES:
NA.24

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等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to Ph. Eur. Y0001082
traceable to USP 1285931

API类

fluvastatin

CofA

current certificate can be downloaded

包装

ampule of 1 × 1 g

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

pharmaceutical (small molecule)

包装形式

neat

储存温度

2-30°C

SMILES字符串

[Na+].CC(C)n1c(\C=C\[C@H](O)C[C@H](O)CC([O-])=O)c(-c2ccc(F)cc2)c3ccccc13

InChI

1S/C24H26FNO4.Na/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30;/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30);/q;+1/p-1/b12-11+;/t18-,19-;/m0./s1

InChI key

ZGGHKIMDNBDHJB-RPQBTBOMSA-M

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相关类别

一般描述

Fluvastatin sodium is a lipid-lowering drug that belongs to the group of compounds known as statins. It acts by inhibiting the enzyme HMG-CoA reductase that plays a key role in the cholesterol production. It is generally used to reduce plasma cholesterol levels and prevent cardiovascular disease.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

应用

Fluvastatin sodium may be used as a reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by high performance liquid chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

其他说明

To see an example of a Certificate of Analysis for this material enter LRAA5290 in the slot below. This is an example certificate only and may not be the lot that you receive.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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Fluvastatin Sodium
USP42/NF37: United States Pharmacopeia and National Formulary
United States Pharmacopeia/National Formulary, 43(5), 1972-1972 (2019)
The role of statin drugs in combating cardiovascular diseases-A review
Pichandi S, et al
International journal of current science research, 1(2), 47-56 (2011)
Development and validation of stability-indicating HPLC methods for quantitative determination of pravastatin, fluvastatin, atorvastatin, and rosuvastatin in pharmaceuticals
Gomes FP, et al.
Analytical Letters, 42(12), 1784-1804 (2009)
Determination of Fluvastatin Sodium Extended-release Tablets by HPLC
Zhang S, et al.
China Pharmacy, 42(34), 1784-1804 (2007)
Masao Nishiya et al.
Anti-cancer drugs, 30(5), 451-457 (2019-03-29)
Although vemurafenib has been shown to improve the overall survival of patients with metastatic melanoma harboring the BRAF V600E mutation, its efficacy is often hampered by drug resistance acquired within a relatively short period through several distinct mechanisms. In the
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