PHR1964
布洛芬杂质F
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
3-(4-Isobutylphenyl)propionic acid, 3-[4-(2-METHYLPROPYL)PHENYL] PROPANOIC ACID
产品名称
布洛芬杂质F, Pharmaceutical Secondary Standard; Certified Reference Material
SMILES string
OC(=O)CCc1ccc(cc1)CC(C)C
InChI
1S/C13H18O2/c1-10(2)9-12-5-3-11(4-6-12)7-8-13(14)15/h3-6,10H,7-9H2,1-2H3,(H,14,15)
InChI key
DYNVRFFVBZVRND-UHFFFAOYSA-N
grade
certified reference material
pharmaceutical secondary standard
agency
traceable to Ph. Eur. Y0000140
API family
ibuprofen
CofA
current certificate can be downloaded
packaging
pkg of 30 mg
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
Quality Level
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Analysis Note
These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.
Application
Ibuprofen may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by analytical techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
General description
Ibuprofen Impurity F is an impurity of the drug, ibuprofen. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that is effective against pain, inflammation and fever. It is deemed as a safe drug on account of its reversible inhibitory effects on cyclooxygenase (COX) enzyme along with its unique pharmacokinetics.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB2590 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Ibuprofen: A critical bibliographic review (1999)
Determination of enantiomeric composition of ibuprofen in pharmaceutical formulations by partial least-squares regression of strongly overlapped chromatographic profiles
Grisales JO, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 910, 78-83 (2012)
Two liquid chromatographic methods for the simultaneous determination of ibuprofen and methocarbamol or chlorzoxazone in the presence of their degradation products
Elkady EF and Fouad MA
Journal of Liquid Chromatography and Related Technologies, 35(7), 882-895 (2012)
Ibuprofen
USP42-NF37: United States Pharmacopeia and National Formulary
United States Pharmacopeia/National Formulary, 34(4), 2232-2232 (2018)
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