1147009
USP
Colistimethate sodium
United States Pharmacopeia (USP) Reference Standard
别名:
Colistin sulphomethate sodium
等级
pharmaceutical primary standard
API类
colistimethate
表单
solid
制造商/商品名称
USP
应用
USP Biologics
pharmaceutical (small molecule)
包装形式
neat
储存温度
−20°C
SMILES字符串
[Na+].[Na+].[Na+].[Na+].[Na+].[S](=O)(=O)([O-])CNCCC1NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(CCNC(=O)C(NC1=O)C(O)C)NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CCCCC(CC)C)CCNC[S](=O)(=O)[O-])C(O)C)CCNC[S](=O)(=O)[O-])CCNC[S](=O)(=O)[O-])CC(C)C)CC(C)C)CCNC[S](=O)(=O)[O-]
InChI
1S/C58H110N16O28S5.5Na/c1-9-35(6)12-10-11-13-46(77)65-38(14-20-59-28-103(88,89)90)53(82)74-48(37(8)76)58(87)70-41(17-23-62-31-106(97,98)99)50(79)68-43-19-25-64-57(86)47(36(7)75)73-54(83)42(18-24-63-32-107(100,101)102)67-49(78)39(15-21-60-29-104(91,92)93)69-55(84)44(26-33(2)3)72-56(85)45(27-34(4)5)71-52(81)40(66-51(43)80)16-22-61-30-105(94,95)96;;;;;/h33-45,47-48,59-63,75-76H,9-32H2,1-8H3,(H,64,86)(H,65,77)(H,66,80)(H,67,78)(H,68,79)(H,69,84)(H,70,87)(H,71,81)(H,72,85)(H,73,83)(H,74,82)(H,88,89,90)(H,91,92,93)(H,94,95,96)(H,97,98,99)(H,100,101,102);;;;;/q;5*+1/p-5
InChI key
IQWHCHZFYPIVRV-UHFFFAOYSA-I
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一般描述
Colistimethate sodium is a prodrug of colistin, designed to reduce toxicity and improve solubility. It exhibits activity against Gram-negative bacteria by disrupting membrane integrity. The USP reference standard supports microbiological assay and identity verification protocols.
The USP biologics antibiotics category includes a wide range of antimicrobial agents that are essential in treating bacterial infections. These antibiotics are derived from various natural sources or synthesized to combat specific pathogens effectively. The USP provides comprehensive standards, reference materials, and analytical procedures to ensure the identity, quality, purity, and consistency of antibiotic therapeutics throughout their lifecycle.
The United States Pharmacopeia (USP) provides quality standards for biologics to ensure their safety, efficacy, and quality throughout the manufacturing process. These standards assist manufacturers in adhering to regulatory requirements and help safeguard public health by reducing risks associated with biologics.
应用
分析说明
其他说明
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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