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主要文件

1547007

USP

Polymyxin B sulfate

United States Pharmacopeia (USP) Reference Standard

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About This Item

CAS Number:
1405-20-5
MDL编号:
MFCD30489731
UNSPSC代码:
41116107
NACRES:
NA.24

等级

pharmaceutical primary standard

API类

polymyxin

表单

powder

制造商/商品名称

USP

应用

pharmaceutical (small molecule)

包装形式

neat

储存温度

2-8°C

SMILES字符串

[S](=O)(=O)(O)O.N1CCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C1=O)CCO)CCN)CCN)CC(C)C)Cc2ccccc2)CCN)NC(=O)C(NC(=O)C(NC(=O)C(NC=O)CCN)CCO)CCN

InChI

1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)

InChI key

HNDFYNOVSOOGDU-UHFFFAOYSA-N

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相关类别

一般描述

Polymyxin B sulfate is a mixture of closely related cyclic polypeptides produced by Bacillus polymyxa. It disrupts the integrity of Gram-negative bacterial membranes by binding to lipopolysaccharides. The USP reference standard is used in microbiological potency assays and system suitability testing.

The USP biologics antibiotics category includes a wide range of antimicrobial agents that are essential in treating bacterial infections. These antibiotics are derived from various natural sources or synthesized to combat specific pathogens effectively. The USP provides comprehensive standards, reference materials, and analytical procedures to ensure the identity, quality, purity, and consistency of antibiotic therapeutics throughout their lifecycle.

The United States Pharmacopeia (USP) provides quality standards for biologics to ensure their safety, efficacy, and quality throughout the manufacturing process. These standards assist manufacturers in adhering to regulatory requirements and help safeguard public health by reducing risks associated with biologics.

应用

Polymyxin B sulfate USP Reference standard suitable for use in specified USP compendial tests and assays. Also, for use with USP monographs such as:
  • Bacitracin and Polymyxin B Sulfate Topical Aerosol®
  • Oxytetracycline Hydrochloride and Polymyxin B Sulfate Ointment
  • Polymyxin B Sulfate and Trimethoprim Ophthalmic Solution
  • Bacitracin Zinc and Polymyxin B Sulfate Ointment
  • Polymyxin B Sulfate and Hydrocortisone Otic Solution
  • Chloramphenicol and Polymyxin B Sulfate Ophthalmic Ointment
  • Oxytetracycline Hydrochloride and Polymyxin B Sulfate Ophthalmic Ointment

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

This product is part of USP Biologics Program.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Sales restrictions may apply.

法律信息

Aerosol is a registered trademark of Cytec Technology Corp.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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